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    NEK7 NIMA related kinase 7 [ Homo sapiens (human) ]

    Gene ID: 140609, updated on 3-Dec-2024

    Summary

    Official Symbol
    NEK7provided by HGNC
    Official Full Name
    NIMA related kinase 7provided by HGNC
    Primary source
    HGNC:HGNC:13386
    See related
    Ensembl:ENSG00000151414 MIM:606848; AllianceGenome:HGNC:13386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
    Expression
    Ubiquitous expression in heart (RPKM 38.5), fat (RPKM 31.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NEK7 in Genome Data Viewer
    Location:
    1q31.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (198156998..198322420)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (197416379..197581805)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198126128..198291550)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:197887073-197887799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:197890605-197891127 Neighboring gene chromosome 1 open reading frame 53 Neighboring gene LIM homeobox 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:198001212-198001386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:198025825-198026449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2284 Neighboring gene proline rich 13 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 4677 Neighboring gene VISTA enhancer hs1322 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:198283627-198284283 Neighboring gene NANOG hESC enhancer GRCh37_chr1:198392710-198393375 Neighboring gene uncharacterized LOC105371677 Neighboring gene ATPase H+ transporting V1 subunit G3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular function activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek7
    Names
    NIMA (never in mitosis gene a)-related kinase 7
    never in mitosis A-related kinase 7
    nimA-related protein kinase 7
    NP_598001.1
    XP_011507511.1
    XP_016855833.1
    XP_016855834.1
    XP_016855835.1
    XP_016855836.1
    XP_047302516.1
    XP_047302517.1
    XP_047302518.1
    XP_047302519.1
    XP_047302520.1
    XP_047302521.1
    XP_047302523.1
    XP_047302524.1
    XP_047302525.1
    XP_047302526.1
    XP_047302528.1
    XP_054190469.1
    XP_054190470.1
    XP_054190471.1
    XP_054190472.1
    XP_054190473.1
    XP_054190474.1
    XP_054190475.1
    XP_054190476.1
    XP_054190477.1
    XP_054190478.1
    XP_054190479.1
    XP_054190480.1
    XP_054190481.1
    XP_054190482.1
    XP_054190483.1
    XP_054190484.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133494.3NP_598001.1  serine/threonine-protein kinase Nek7

      See identical proteins and their annotated locations for NP_598001.1

      Status: VALIDATED

      Source sequence(s)
      AC093419, AK313411, DB498485
      Consensus CDS
      CCDS1394.1
      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
      UniProtKB/TrEMBL
      B2R8K8
      Related
      ENSP00000356355.4, ENST00000367385.9
      Conserved Domains (1) summary
      cd08224
      Location:33294
      STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      198156998..198322420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446560.1XP_047302516.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8
    2. XM_047446563.1XP_047302519.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
      UniProtKB/TrEMBL
      B2R8K8
    3. XM_047446572.1XP_047302528.1  serine/threonine-protein kinase Nek7 isoform X7

    4. XM_017000345.2XP_016855834.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8
    5. XM_047446562.1XP_047302518.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
      UniProtKB/TrEMBL
      B2R8K8
    6. XM_047446567.1XP_047302523.1  serine/threonine-protein kinase Nek7 isoform X4

      UniProtKB/TrEMBL
      B2R8K8
    7. XM_047446570.1XP_047302526.1  serine/threonine-protein kinase Nek7 isoform X7

    8. XM_017000344.2XP_016855833.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8
    9. XM_017000346.2XP_016855835.1  serine/threonine-protein kinase Nek7 isoform X3

      UniProtKB/TrEMBL
      B2R8K8
    10. XM_047446565.1XP_047302521.1  serine/threonine-protein kinase Nek7 isoform X4

      UniProtKB/TrEMBL
      B2R8K8
    11. XM_011509209.2XP_011507511.1  serine/threonine-protein kinase Nek7 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:9158
      PKc_like; Protein Kinases, catalytic domain
    12. XM_047446569.1XP_047302525.1  serine/threonine-protein kinase Nek7 isoform X6

    13. XM_017000347.2XP_016855836.1  serine/threonine-protein kinase Nek7 isoform X5

    14. XM_047446568.1XP_047302524.1  serine/threonine-protein kinase Nek7 isoform X6

    15. XM_047446561.1XP_047302517.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8
    16. XM_047446564.1XP_047302520.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
      UniProtKB/TrEMBL
      B2R8K8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      197416379..197581805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334495.1XP_054190470.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8
    2. XM_054334498.1XP_054190473.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
      UniProtKB/TrEMBL
      B2R8K8
    3. XM_054334503.1XP_054190478.1  serine/threonine-protein kinase Nek7 isoform X4

      UniProtKB/TrEMBL
      B2R8K8
    4. XM_054334508.1XP_054190483.1  serine/threonine-protein kinase Nek7 isoform X7

    5. XM_054334494.1XP_054190469.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8
    6. XM_054334501.1XP_054190476.1  serine/threonine-protein kinase Nek7 isoform X3

      UniProtKB/TrEMBL
      B2R8K8
    7. XM_054334502.1XP_054190477.1  serine/threonine-protein kinase Nek7 isoform X4

      UniProtKB/TrEMBL
      B2R8K8
    8. XM_054334507.1XP_054190482.1  serine/threonine-protein kinase Nek7 isoform X7

    9. XM_054334506.1XP_054190481.1  serine/threonine-protein kinase Nek7 isoform X6

    10. XM_054334504.1XP_054190479.1  serine/threonine-protein kinase Nek7 isoform X5

    11. XM_054334505.1XP_054190480.1  serine/threonine-protein kinase Nek7 isoform X6

    12. XM_054334496.1XP_054190471.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8
    13. XM_054334499.1XP_054190474.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
      UniProtKB/TrEMBL
      B2R8K8
    14. XM_054334509.1XP_054190484.1  serine/threonine-protein kinase Nek7 isoform X7

    15. XM_054334497.1XP_054190472.1  serine/threonine-protein kinase Nek7 isoform X1

      UniProtKB/TrEMBL
      B2R8K8
    16. XM_054334500.1XP_054190475.1  serine/threonine-protein kinase Nek7 isoform X2

      UniProtKB/Swiss-Prot
      A6NGT8, Q8TDX7
      UniProtKB/TrEMBL
      B2R8K8