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    PTPRC protein tyrosine phosphatase receptor type C [ Homo sapiens (human) ]

    Gene ID: 5788, updated on 9-Dec-2024

    Summary

    Official Symbol
    PTPRCprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Cprovided by HGNC
    Primary source
    HGNC:HGNC:9666
    See related
    Ensembl:ENSG00000081237 MIM:151460; AllianceGenome:HGNC:9666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
    Expression
    Biased expression in lymph node (RPKM 119.6), appendix (RPKM 101.8) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTPRC in Genome Data Viewer
    Location:
    1q31.3-q32.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (198638713..198757476)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (197898421..198017392)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198608170..198726605)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G3 Neighboring gene uncharacterized LOC124904478 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10450 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:198637893-198639092 Neighboring gene PTPRC intron CAGE-defined mid-level expression enhancer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:198670715-198671264 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1667 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:198776880-198778079 Neighboring gene MIR181A1 host gene Neighboring gene microRNA 181b-1 Neighboring gene microRNA 181a-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Immunodeficiency 105
    MedGen: C5677005 OMIM: 619924 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of protein tyrosine phosphatase, receptor type C (PTPRC; CD45) in human B cells PubMed
    env CD4(+)CD45RO(+) cells display high HIV-1 gp120-binding capacity, whereas CD4(+)CD45RO(-) cells show undetectable HIV-1 gp120 binding PubMed
    env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
    env HIV-1 gp120-induced apoptosis is regulated by CD45 through inducing CD45 association with the HIV coreceptor CXCR4 in T cell lines and peripheral blood mononuclear cells PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with PTPRC; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
    Nef nef HIV-1 Nef increases intracellular expression of CD45 and AChE concomitant with release of Nef, CD45, and AChE PubMed
    Tat tat HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heparan sulfate proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DN2 thymocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone marrow development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell adhesion involved in substrate-bound cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-4-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of microglial cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane raft distribution ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of antigen receptor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hematopoietic stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of isotype switching to IgG isotypes IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to aldosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in stem cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in bleb IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane microdomain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase C
    Names
    CD45 antigen
    T200 glycoprotein
    T200 leukocyte common antigen
    glycoprotein 180
    protein tyrosine phosphatase, receptor type, c polypeptide
    NP_001254727.1
    NP_002829.3
    NP_563578.2
    XP_006711535.1
    XP_006711536.1
    XP_006711537.1
    XP_047282337.1
    XP_047282354.1
    XP_047282365.1
    XP_047282371.1
    XP_047282373.1
    XP_047282376.1
    XP_054193920.1
    XP_054193921.1
    XP_054193922.1
    XP_054193923.1
    XP_054193924.1
    XP_054193925.1
    XP_054193926.1
    XP_054193927.1
    XP_054193928.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007730.2 RefSeqGene

      Range
      4946..123382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_95

    mRNA and Protein(s)

    1. NM_001267798.2NP_001254727.1  receptor-type tyrosine-protein phosphatase C isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC031525, DA819314
      Consensus CDS
      CCDS44291.2
      UniProtKB/TrEMBL
      A0A140TA59, M9MML4
      Related
      ENSP00000405494.3, ENST00000413409.6
      Conserved Domains (1) summary
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
    2. NM_002838.5NP_002829.3  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

      See identical proteins and their annotated locations for NP_002829.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA403163, AK292131, BM791051, DA819314, Y00062, Y00638
      Consensus CDS
      CCDS1397.2
      UniProtKB/Swiss-Prot
      A0A0A0MT22, A8K7W6, P08575, Q16614, Q9H0Y6, X6R433
      Related
      ENSP00000411355.3, ENST00000442510.8
      Conserved Domains (6) summary
      PHA03255
      Location:81231
      PHA03255; BDLF3; Provisional
      cd00063
      Location:485565
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14557
      Location:707907
      R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
      cd14558
      Location:10171223
      R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:237295
      CD45; Leukocyte receptor CD45
    3. NM_080921.4NP_563578.2  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

      See identical proteins and their annotated locations for NP_563578.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AA403163, AK292131, BM791051, DA819314, Y00062
      Consensus CDS
      CCDS1398.2
      UniProtKB/TrEMBL
      A0A8V8TLH9
      Related
      ENSP00000306782.7, ENST00000348564.12
      Conserved Domains (5) summary
      cd00063
      Location:324404
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14557
      Location:546746
      R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
      cd14558
      Location:8561062
      R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:76134
      CD45; Leukocyte receptor CD45

    RNA

    1. NR_052021.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs at its 3' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, and there is no support for the existence of this very short protein.
      Source sequence(s)
      AA904360, BC017863, DA819314
      Related
      ENST00000367364.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      198638713..198757476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426381.1XP_047282337.1  receptor-type tyrosine-protein phosphatase C isoform X1

      UniProtKB/Swiss-Prot
      A0A0A0MT22, A8K7W6, P08575, Q16614, Q9H0Y6, X6R433
    2. XM_047426398.1XP_047282354.1  receptor-type tyrosine-protein phosphatase C isoform X3

    3. XM_047426409.1XP_047282365.1  receptor-type tyrosine-protein phosphatase C isoform X4

      UniProtKB/TrEMBL
      A0A8V8TLH9
    4. XM_047426415.1XP_047282371.1  receptor-type tyrosine-protein phosphatase C isoform X5

      UniProtKB/TrEMBL
      A0A8V8TLH9
    5. XM_006711472.5XP_006711535.1  receptor-type tyrosine-protein phosphatase C isoform X2

      See identical proteins and their annotated locations for XP_006711535.1

      Related
      ENSP00000513363.1, ENST00000697631.1
      Conserved Domains (6) summary
      PHA03255
      Location:18183
      PHA03255; BDLF3; Provisional
      smart00194
      Location:604863
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:632863
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:437517
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:189245
      CD45; Leukocyte receptor CD45
    6. XM_006711473.4XP_006711536.1  receptor-type tyrosine-protein phosphatase C isoform X3

      Conserved Domains (6) summary
      PHA03255
      Location:27165
      PHA03255; BDLF3; Provisional
      smart00194
      Location:586845
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:614845
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:419499
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:171227
      CD45; Leukocyte receptor CD45
    7. XM_006711474.4XP_006711537.1  receptor-type tyrosine-protein phosphatase C isoform X4

      UniProtKB/TrEMBL
      A0A8V8TLH9
      Conserved Domains (5) summary
      smart00194
      Location:538797
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:566797
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:371451
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:123179
      CD45; Leukocyte receptor CD45
    8. XM_047426420.1XP_047282376.1  receptor-type tyrosine-protein phosphatase C isoform X6

    9. XM_047426417.1XP_047282373.1  receptor-type tyrosine-protein phosphatase C isoform X6

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315907.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      280445..359708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      197898421..198017392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337951.1XP_054193926.1  receptor-type tyrosine-protein phosphatase C isoform X5

      UniProtKB/TrEMBL
      A0A8V8TLH9
    2. XM_054337945.1XP_054193920.1  receptor-type tyrosine-protein phosphatase C isoform X1

      UniProtKB/Swiss-Prot
      A0A0A0MT22, A8K7W6, P08575, Q16614, Q9H0Y6, X6R433
    3. XM_054337948.1XP_054193923.1  receptor-type tyrosine-protein phosphatase C isoform X3

    4. XM_054337950.1XP_054193925.1  receptor-type tyrosine-protein phosphatase C isoform X4

      UniProtKB/TrEMBL
      A0A8V8TLH9
    5. XM_054337946.1XP_054193921.1  receptor-type tyrosine-protein phosphatase C isoform X2

    6. XM_054337947.1XP_054193922.1  receptor-type tyrosine-protein phosphatase C isoform X3

    7. XM_054337949.1XP_054193924.1  receptor-type tyrosine-protein phosphatase C isoform X4

      UniProtKB/TrEMBL
      A0A8V8TLH9
    8. XM_054337953.1XP_054193928.1  receptor-type tyrosine-protein phosphatase C isoform X6

    9. XM_054337952.1XP_054193927.1  receptor-type tyrosine-protein phosphatase C isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_080922.2: Suppressed sequence

      Description
      NM_080922.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.