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    FPR1 formyl peptide receptor 1 [ Homo sapiens (human) ]

    Gene ID: 2357, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FPR1provided by HGNC
    Official Full Name
    formyl peptide receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:3826
    See related
    Ensembl:ENSG00000171051 MIM:136537; AllianceGenome:HGNC:3826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPR; FMLP
    Summary
    This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
    Expression
    Biased expression in appendix (RPKM 94.6), bone marrow (RPKM 64.2) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FPR1 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51745172..51751878, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54832367..54839072, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52248425..52255131, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene hyaluronan synthase 1 Neighboring gene uncharacterized LOC124904754 Neighboring gene Sharpr-MPRA regulatory region 4853 Neighboring gene formyl peptide receptor 2 Neighboring gene Sharpr-MPRA regulatory region 3543 Neighboring gene uncharacterized LOC105372448

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Association of SNPs in N-formylpeptide receptor gene with susceptibility of aggressive periodontitis]. Zhu XL, et al. Beijing Da Xue Xue Bao Yi Xue Ban, 2009 Dec 18. PMID 20019777
    2. Multiple receptor states are required to describe both kinetic binding and activation of neutrophils via N-formyl peptide receptor ligands. Kinzer-Ursem TL, et al. Cell Signal, 2006 Oct. PMID 16530386
    3. Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent beta-arrestin association and indices of inflammation. Bhattacharya M, et al. Pharmacogenomics J, 2007 Jun. PMID 16953235
    4. Expression and functional role of formyl peptide receptor in human bone marrow-derived mesenchymal stem cells. Kim MK, et al. FEBS Lett, 2007 May 1. PMID 17442310
    5. Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. Gunji T, et al. Biochem Biophys Res Commun, 2007 Dec 7. PMID 17927965

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FPR1: A critical gatekeeper of the heart and brain.
      Title: FPR1: A critical gatekeeper of the heart and brain.
    2. Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer.
      Title: Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer.
    3. Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
      Title: Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
    4. Amyloid beta and its naturally occurring N-terminal variants are potent activators of human and mouse formyl peptide receptor 1.
      Title: Amyloid beta and its naturally occurring N-terminal variants are potent activators of human and mouse formyl peptide receptor 1.
    5. Agonist concentration-dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions.
      Title: Agonist concentration-dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions.
    6. Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
      Title: Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
    7. Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling.
      Title: Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling.
    8. The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
      Title: The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
    9. Evaluation of the Genetic Association and Methylation of Immune Response Pathway Genes with the Risk of Chronic Periodontitis in the Uighur Population.
      Title: Evaluation of the Genetic Association and Methylation of Immune Response Pathway Genes with the Risk of Chronic Periodontitis in the Uighur Population.
    10. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo.
      Title: Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (107)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Interaction of HIV-1 gp120 with CD4 is sufficient to trigger a marked reduction in C5a Receptor and a modest reduction in FMLP Receptor on monocytes PubMed
    env N-formyl-methionyl-leucylphenyl-alanine binding to formyl peptide receptor (FPR) results in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1 gp120-mediated fusion and infection of cells expressing CD4, CCR5, and FPR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-formyl peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-formyl peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RAGE receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scavenger receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nitric oxide mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    fMet-Leu-Phe receptor
    Names
    N-formylpeptide chemoattractant receptor
    fMLP receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023426.1 RefSeqGene

      Range
      5001..11128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_146

    mRNA and Protein(s)

    1. NM_001193306.2 → NP_001180235.1  fMet-Leu-Phe receptor

      See identical proteins and their annotated locations for NP_001180235.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC018755
      Consensus CDS
      CCDS12839.1
      UniProtKB/Swiss-Prot
      P21462, Q14939, Q7Z6A4, Q86U52, Q9NS48
      UniProtKB/TrEMBL
      B2RC44
      Related
      ENSP00000471493.1, ENST00000595042.5
      Conserved Domains (2) summary
      cd14964
      Location:29 → 53
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:27 → 312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_002029.4 → NP_002020.1  fMet-Leu-Phe receptor

      See identical proteins and their annotated locations for NP_002020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC005315, BQ016000, M60627
      Consensus CDS
      CCDS12839.1
      UniProtKB/Swiss-Prot
      P21462, Q14939, Q7Z6A4, Q86U52, Q9NS48
      UniProtKB/TrEMBL
      B2RC44
      Related
      ENSP00000302707.3, ENST00000304748.5
      Conserved Domains (2) summary
      cd14964
      Location:29 → 53
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:27 → 312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51745172..51751878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54832367..54839072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21462.3 GenPept UniProtKB/Swiss-Prot:P21462

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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