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    ARHGAP22 Rho GTPase activating protein 22 [ Homo sapiens (human) ]

    Gene ID: 58504, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARHGAP22provided by HGNC
    Official Full Name
    Rho GTPase activating protein 22provided by HGNC
    Primary source
    HGNC:HGNC:30320
    See related
    Ensembl:ENSG00000128805 MIM:610585; AllianceGenome:HGNC:30320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RhoGAP2; RhoGap22
    Summary
    This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGAP22 in Genome Data Viewer
    Location:
    10q11.22-q11.23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (48429831..48656265, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (49275552..49505563, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (49654079..49864310, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:49394772-49395971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49397051-49398006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3329 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49441449-49441950 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49450548-49450771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:49455107-49455608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49495838-49496338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2355 Neighboring gene ribosomal protein S6 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 12210 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:49607374-49608116 Neighboring gene Sharpr-MPRA regulatory region 2186 Neighboring gene Sharpr-MPRA regulatory region 5880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49653211-49654112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49662087-49663064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49668057-49668559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49671373-49672306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49672307-49673238 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49674919-49675115 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49678026-49678908 Neighboring gene Sharpr-MPRA regulatory region 4601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49686951-49687608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49687609-49688265 Neighboring gene Sharpr-MPRA regulatory region 14185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49716013-49716998 Neighboring gene ARHGAP22 intronic transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49725473-49726106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49727221-49727810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49727811-49728398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2356 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:49741600-49742140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49750999-49751784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49763487-49763987 Neighboring gene NANOG hESC enhancer GRCh37_chr10:49782573-49783074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3331 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:49802653-49803477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49807300-49807800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49812539-49813269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3336 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49887725-49887989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49893168-49893708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49953319-49953863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3340 Neighboring gene WDFY family member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3341 Neighboring gene ribosomal protein L13a pseudogene 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3343 Neighboring gene uncharacterized LOC105378299

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells. Mori M, et al. Anticancer Res, 2022 Dec. PMID 36456117
    2. Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin. Rowland AF, et al. Mol Cell Biol, 2011 Dec. PMID 21969604, Free PMC Article
    3. Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy. Li R, et al. J Gene Med, 2017 Jun. PMID 28544509
    4. The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode. Hu SH, et al. PLoS One, 2012. PMID 22952583, Free PMC Article
    5. The molecular genetic architecture of self-employment. van der Loos MJ, et al. PLoS One, 2013. PMID 23593239, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells.
      Title: Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells.
    2. DNA hypermethylation is associated with invasive phenotype of malignant melanoma.
      Title: DNA hypermethylation is associated with invasive phenotype of malignant melanoma.
    3. rs10491034 of gene ARHGAP22 is associated with diabetic retinopathy incidence and severity among Chinese Hui population.
      Title: Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.
    4. There is a significant association between single nucleotide polymorphism in the ARHGAP22 gene and diabetic retinopathy risk in a Han Chinese population
      Title: Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy.
    5. a weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode
      Title: The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode.
    6. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling.
      Title: The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.
    7. Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin
      Title: Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin.
    8. We identified a genetic association for susceptibility to retinopathy in 5 novel chromosomal regions and PLXDC2 and ARHGAP22, the latter 2 of which are genes implicated in endothelial cell angiogenesis and increased capillary permeability.
      Title: Genome-wide association study of diabetic retinopathy in a Taiwanese population.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of conduct disorder symptomatology.
    EBI GWAS Catalog
    Genome-wide association study of diabetic retinopathy in a Taiwanese population.
    EBI GWAS Catalog
    The molecular genetic architecture of self-employment.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 22
    Names
    rho-type GTPase-activating protein 22

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053158.1 RefSeqGene

      Range
      56193..215230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256024.2 → NP_001242953.1  rho GTPase-activating protein 22 isoform 1

      See identical proteins and their annotated locations for NP_001242953.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC016397, AC016399, BC126444, DB338179
      Consensus CDS
      CCDS58080.1
      UniProtKB/TrEMBL
      A0A2X0SFC0, B3KNU1
      Related
      ENSP00000412461.2, ENST00000417912.6
      Conserved Domains (3) summary
      cd04390
      Location:167 → 365
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:36 → 151
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      cl25732
      Location:606 → 694
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001256025.3 → NP_001242954.1  rho GTPase-activating protein 22 isoform 2

      See identical proteins and their annotated locations for NP_001242954.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
      Source sequence(s)
      AK293579, AY324801, DC391765
      Consensus CDS
      CCDS58081.1
      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000416701.2, ENST00000435790.6
      Conserved Domains (4) summary
      cd04390
      Location:157 → 355
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:44 → 150
      PH; PH domain
      cl05005
      Location:556 → 685
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    3. NM_001256026.2 → NP_001242955.1  rho GTPase-activating protein 22 isoform 4

      See identical proteins and their annotated locations for NP_001242955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, uses an alternate in-frame splice site in a 5' exon, and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC016397, AK127586, DB338179
      Consensus CDS
      CCDS58079.1
      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000410054.2, ENST00000417247.6
      Conserved Domains (4) summary
      cd04390
      Location:61 → 259
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:29 → 54
      PH; PH domain
      cl05005
      Location:460 → 589
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17171
      Location:18 → 61
      PH-like; Pleckstrin homology-like domain

    4. NM_001347735.2 → NP_001334664.1  rho GTPase-activating protein 22 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399
      UniProtKB/TrEMBL
      B3KNU1

    5. NM_001347736.2 → NP_001334665.1  rho GTPase-activating protein 22 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC016399, AC068898
      Conserved Domains (1) summary
      cl17171
      Location:42 → 84
      PH-like; Pleckstrin homology-like domain

    6. NM_001347737.2 → NP_001334666.1  rho GTPase-activating protein 22 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC016399

    7. NM_001347738.2 → NP_001334667.1  rho GTPase-activating protein 22 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC016397, AC016399, AC068898
      Consensus CDS
      CCDS58081.1
      UniProtKB/TrEMBL
      B3KNU1

    8. NM_021226.4 → NP_067049.2  rho GTPase-activating protein 22 isoform 3

      See identical proteins and their annotated locations for NP_067049.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared with isoform 1.
      Source sequence(s)
      AY324801
      Consensus CDS
      CCDS7227.1
      UniProtKB/Swiss-Prot
      A0AVP7, A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0, Q7Z5H3
      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000249601.4, ENST00000249601.9
      Conserved Domains (4) summary
      cd04390
      Location:151 → 349
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:36 → 151
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:38 → 144
      PH; PH domain
      cl05005
      Location:550 → 679
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    RNA

    1. NR_045675.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains alternate 5' exons and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC016397, AK055937, DB338179
      Related
      ENST00000460425.1

    2. NR_144642.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399

    3. NR_144643.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399

    4. NR_144644.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399

    5. NR_144645.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399

    6. NR_144646.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC016399

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      48429831..48656265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448100.2 → XP_024303868.1  rho GTPase-activating protein 22 isoform X14

      Conserved Domains (2) summary
      cd04390
      Location:157 → 347
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain

    2. XM_011540013.4 → XP_011538315.1  rho GTPase-activating protein 22 isoform X12

      Conserved Domains (3) summary
      cd04390
      Location:173 → 363
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:44 → 150
      PH; PH domain

    3. XM_017016476.2 → XP_016871965.1  rho GTPase-activating protein 22 isoform X16

    4. XM_011540003.2 → XP_011538305.1  rho GTPase-activating protein 22 isoform X1

      See identical proteins and their annotated locations for XP_011538305.1

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (3) summary
      cd04390
      Location:173 → 371
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      cl25732
      Location:612 → 700
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_011540006.3 → XP_011538308.1  rho GTPase-activating protein 22 isoform X5

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (4) summary
      cd04390
      Location:114 → 312
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:44 → 111
      PH; PH domain
      cl05005
      Location:513 → 642
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17171
      Location:42 → 127
      PH-like; Pleckstrin homology-like domain

    6. XM_047425586.1 → XP_047281542.1  rho GTPase-activating protein 22 isoform X2

    7. XM_011540015.4 → XP_011538317.1  rho GTPase-activating protein 22 isoform X17

      Conserved Domains (3) summary
      cd04390
      Location:173 → 351
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:44 → 150
      PH; PH domain

    8. XM_011540002.3 → XP_011538304.1  rho GTPase-activating protein 22 isoform X1

      See identical proteins and their annotated locations for XP_011538304.1

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (3) summary
      cd04390
      Location:173 → 371
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      cl25732
      Location:612 → 700
      SMC_N; RecF/RecN/SMC N terminal domain

    9. XM_024448099.2 → XP_024303867.1  rho GTPase-activating protein 22 isoform X1

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (3) summary
      cd04390
      Location:173 → 371
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      cl25732
      Location:612 → 700
      SMC_N; RecF/RecN/SMC N terminal domain

    10. XM_011540011.3 → XP_011538313.1  rho GTPase-activating protein 22 isoform X10

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (2) summary
      cd04390
      Location:18 → 216
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cl05005
      Location:417 → 546
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    11. XM_047425589.1 → XP_047281545.1  rho GTPase-activating protein 22 isoform X8

      Related
      ENSP00000363285.1, ENST00000374170.5

    12. XM_005270014.4 → XP_005270071.1  rho GTPase-activating protein 22 isoform X6

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (4) summary
      cd04390
      Location:77 → 275
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:29 → 54
      PH; PH domain
      cl05005
      Location:476 → 605
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17171
      Location:18 → 61
      PH-like; Pleckstrin homology-like domain

    13. XM_011540005.2 → XP_011538307.1  rho GTPase-activating protein 22 isoform X4

      UniProtKB/TrEMBL
      B3KNU1
      Related
      ENSP00000363287.1, ENST00000374172.5
      Conserved Domains (4) summary
      cd04390
      Location:77 → 275
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:29 → 54
      PH; PH domain
      cl05005
      Location:476 → 605
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17171
      Location:18 → 61
      PH-like; Pleckstrin homology-like domain

    14. XM_047425588.1 → XP_047281544.1  rho GTPase-activating protein 22 isoform X7

    15. XM_047425590.1 → XP_047281546.1  rho GTPase-activating protein 22 isoform X9

    16. XM_047425591.1 → XP_047281547.1  rho GTPase-activating protein 22 isoform X9

    17. XM_047425587.1 → XP_047281543.1  rho GTPase-activating protein 22 isoform X3

    18. XM_017016471.3 → XP_016871960.1  rho GTPase-activating protein 22 isoform X11

      UniProtKB/TrEMBL
      B3KNU1
      Conserved Domains (2) summary
      cd04390
      Location:5 → 203
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cl05005
      Location:404 → 533
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    19. XM_047425593.1 → XP_047281549.1  rho GTPase-activating protein 22 isoform X15

    20. XM_047425592.1 → XP_047281548.1  rho GTPase-activating protein 22 isoform X13

    21. XM_047425594.1 → XP_047281550.1  rho GTPase-activating protein 22 isoform X18

    22. XM_047425595.1 → XP_047281551.1  rho GTPase-activating protein 22 isoform X20

    23. XM_024448102.2 → XP_024303870.1  rho GTPase-activating protein 22 isoform X19

      Conserved Domains (1) summary
      cl17171
      Location:42 → 130
      PH-like; Pleckstrin homology-like domain

    24. XM_024448106.2 → XP_024303874.1  rho GTPase-activating protein 22 isoform X21

      Conserved Domains (1) summary
      cl17171
      Location:42 → 84
      PH-like; Pleckstrin homology-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      49275552..49505563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366471.1 → XP_054222446.1  rho GTPase-activating protein 22 isoform X14

    2. XM_054366469.1 → XP_054222444.1  rho GTPase-activating protein 22 isoform X12

    3. XM_054366473.1 → XP_054222448.1  rho GTPase-activating protein 22 isoform X16

    4. XM_054366457.1 → XP_054222432.1  rho GTPase-activating protein 22 isoform X1

    5. XM_054366458.1 → XP_054222433.1  rho GTPase-activating protein 22 isoform X2

    6. XM_054366455.1 → XP_054222430.1  rho GTPase-activating protein 22 isoform X1

    7. XM_054366461.1 → XP_054222436.1  rho GTPase-activating protein 22 isoform X5

    8. XM_054366474.1 → XP_054222449.1  rho GTPase-activating protein 22 isoform X17

    9. XM_054366456.1 → XP_054222431.1  rho GTPase-activating protein 22 isoform X1

    10. XM_054366464.1 → XP_054222439.1  rho GTPase-activating protein 22 isoform X8

    11. XM_054366462.1 → XP_054222437.1  rho GTPase-activating protein 22 isoform X6

    12. XM_054366460.1 → XP_054222435.1  rho GTPase-activating protein 22 isoform X4

    13. XM_054366463.1 → XP_054222438.1  rho GTPase-activating protein 22 isoform X7

    14. XM_054366465.1 → XP_054222440.1  rho GTPase-activating protein 22 isoform X9

    15. XM_054366468.1 → XP_054222443.1  rho GTPase-activating protein 22 isoform X22

    16. XM_054366466.1 → XP_054222441.1  rho GTPase-activating protein 22 isoform X9

    17. XM_054366459.1 → XP_054222434.1  rho GTPase-activating protein 22 isoform X3

    18. XM_054366467.1 → XP_054222442.1  rho GTPase-activating protein 22 isoform X11

    19. XM_054366472.1 → XP_054222447.1  rho GTPase-activating protein 22 isoform X15

    20. XM_054366470.1 → XP_054222445.1  rho GTPase-activating protein 22 isoform X13

    21. XM_054366475.1 → XP_054222450.1  rho GTPase-activating protein 22 isoform X18

    22. XM_054366477.1 → XP_054222452.1  rho GTPase-activating protein 22 isoform X23

    23. XM_054366479.1 → XP_054222454.1  rho GTPase-activating protein 22 isoform X20

    24. XM_054366476.1 → XP_054222451.1  rho GTPase-activating protein 22 isoform X23

    25. XM_054366478.1 → XP_054222453.1  rho GTPase-activating protein 22 isoform X19

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001256027.1: Suppressed sequence

      Description
      NM_001256027.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z5H3.1 GenPept UniProtKB/Swiss-Prot:Q7Z5H3

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