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    ZNF665 zinc finger protein 665 [ Homo sapiens (human) ]

    Gene ID: 79788, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF665provided by HGNC
    Official Full Name
    zinc finger protein 665provided by HGNC
    Primary source
    HGNC:HGNC:25885
    See related
    Ensembl:ENSG00000197497 AllianceGenome:HGNC:25885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFP160L
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.8), thyroid (RPKM 1.0) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF665 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53162424..53193358, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56244690..56272858, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53665677..53696611, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 415 Neighboring gene zinc finger protein 347 Neighboring gene MPRA-validated peak3548 silencer Neighboring gene MPRA-validated peak3549 silencer Neighboring gene Sharpr-MPRA regulatory region 171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53685451-53685967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11005 Neighboring gene zinc finger protein 480-like Neighboring gene zinc finger protein 415 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study to identify genetic determinants of severe asthma. Wan YI, et al. Thorax, 2012 Sep. PMID 22561531
    2. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Basei FL, et al. Proteome Sci, 2015. PMID 25798074, Free PMC Article
    3. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study to identify genetic determinants of severe asthma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14345

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 665

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353457.2 → NP_001340386.1  zinc finger protein 665 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092070
      Conserved Domains (3) summary
      COG5048
      Location:162 → 550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 46
      KRAB; KRAB box

    2. NM_001353458.2 → NP_001340387.1  zinc finger protein 665 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092070
      Conserved Domains (4) summary
      COG5048
      Location:192 → 580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:37 → 76
      KRAB; KRAB box
      pfam13465
      Location:640 → 664
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001353459.2 → NP_001340388.1  zinc finger protein 665 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092070
      Consensus CDS
      CCDS46169.1
      UniProtKB/Swiss-Prot
      A8K5T8, Q9H7R5
      Conserved Domains (5) summary
      COG5048
      Location:164 → 552
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:292 → 312
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:654 → 676
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:612 → 636
      zf-H2C2_2; Zinc-finger double domain

    4. NM_024733.5 → NP_079009.3  zinc finger protein 665 isoform 3

      See identical proteins and their annotated locations for NP_079009.3

      Status: VALIDATED

      Source sequence(s)
      AC092070
      Consensus CDS
      CCDS46169.1
      UniProtKB/Swiss-Prot
      A8K5T8, Q9H7R5
      Related
      ENSP00000379702.2, ENST00000396424.5
      Conserved Domains (5) summary
      COG5048
      Location:164 → 552
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:292 → 312
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:654 → 676
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:612 → 636
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53162424..53193358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439451.1 → XP_047295407.1  zinc finger protein 665 isoform X6

      UniProtKB/TrEMBL
      A0A3Q5AD24
      Related
      ENSP00000469154.1, ENST00000600412.1

    2. XM_047439450.1 → XP_047295406.1  zinc finger protein 665 isoform X6

      UniProtKB/TrEMBL
      A0A3Q5AD24

    3. XM_047439448.1 → XP_047295404.1  zinc finger protein 665 isoform X4

    4. XM_011527325.4 → XP_011525627.1  zinc finger protein 665 isoform X1

      Conserved Domains (6) summary
      smart00349
      Location:25 → 78
      KRAB; krueppel associated box
      COG5048
      Location:181 → 569
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:559 → 581
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:25 → 64
      KRAB; KRAB box
      pfam13465
      Location:321 → 345
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047439449.1 → XP_047295405.1  zinc finger protein 665 isoform X5

    6. XM_047439446.1 → XP_047295402.1  zinc finger protein 665 isoform X2

      UniProtKB/Swiss-Prot
      A8K5T8, Q9H7R5

    7. XM_047439447.1 → XP_047295403.1  zinc finger protein 665 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56244690..56272858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322184.1 → XP_054178159.1  zinc finger protein 665 isoform X6

    2. XM_054322183.1 → XP_054178158.1  zinc finger protein 665 isoform X6

    3. XM_054322181.1 → XP_054178156.1  zinc finger protein 665 isoform X4

    4. XM_054322182.1 → XP_054178157.1  zinc finger protein 665 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H7R5.3 GenPept UniProtKB/Swiss-Prot:Q9H7R5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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