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    CT45A5 cancer/testis antigen family 45 member A5 [ Homo sapiens (human) ]

    Gene ID: 441521, updated on 10-Dec-2024

    Summary

    Official Symbol
    CT45A5provided by HGNC
    Official Full Name
    cancer/testis antigen family 45 member A5provided by HGNC
    Primary source
    HGNC:HGNC:33270
    See related
    Ensembl:ENSG00000228836 MIM:300796; AllianceGenome:HGNC:33270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT455; CT45-3; CT45-4; CT45-6; CT45.5; CT45A3; CT45A4; CT45A6; CT45A7
    Summary
    This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Expression
    Restricted expression toward testis (RPKM 9.7) See more
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    Genomic context

    See CT45A5 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135775852..135785503, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134033851..134050363)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134866186..134875847)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MGAT2 pseudogene 2 Neighboring gene cancer/testis antigen family 45 member A3 Neighboring gene cancer/testis antigen family 45 member A6 Neighboring gene cancer/testis antigen family 45 member A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    cancer/testis antigen family 45 member A5
    Names
    Cancer/testis antigen 45-3
    Cancer/testis antigen 45-4
    Cancer/testis antigen 45-6
    Cancer/testis antigen 45A3
    Cancer/testis antigen 45A4
    Cancer/testis antigen 45A6
    Cancer/testis antigen 45A7
    Cancer/testis antigen family 45 member A3
    Cancer/testis antigen family 45 member A4
    Cancer/testis antigen family 45 member A6
    Cancer/testis antigen family 45 member A7
    cancer/testis antigen 45-5
    cancer/testis antigen 45A5
    cancer/testis antigen CT45-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016551.3 RefSeqGene

      Range
      4977..14628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007551.6NP_001007552.2  cancer/testis antigen family 45 member A5

      See identical proteins and their annotated locations for NP_001007552.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS35406.1
      UniProtKB/Swiss-Prot
      A8K842, B7ZMC5, P0DMU7, P0DMU8, P0DMV0, Q6NSH3
      Related
      ENSP00000514077.1, ENST00000698999.1
      Conserved Domains (1) summary
      pfam15300
      Location:122183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    2. NM_001172288.2NP_001165759.2  cancer/testis antigen family 45 member A5

      See identical proteins and their annotated locations for NP_001165759.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS35406.1
      UniProtKB/Swiss-Prot
      A8K842, B7ZMC5, P0DMU7, P0DMU8, P0DMV0, Q6NSH3
      Related
      ENSP00000427342.2, ENST00000487941.6
      Conserved Domains (1) summary
      pfam15300
      Location:122183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135775852..135785503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134033851..134050363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327105.1XP_054183080.1  cancer/testis antigen family 45 member A5 isoform X1

      UniProtKB/Swiss-Prot
      B9EIR8, Q5HYN5