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    PRINS psoriasis associated non-protein coding RNA induced by stress [ Homo sapiens (human) ]

    Gene ID: 100169750, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PRINSprovided by HGNC
    Official Full Name
    psoriasis associated non-protein coding RNA induced by stressprovided by HGNC
    Primary source
    HGNC:HGNC:34235
    Gene type
    ncRNA
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCRNA00074
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    10p12.1

    Bibliography

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    Related articles in PubMed

    1. Expression and functional studies on the noncoding RNA, PRINS. Szegedi K, et al. Int J Mol Sci, 2012 Dec 21. PMID 23344029, Free PMC Article
    2. Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells. Bari L, et al. Arch Dermatol Res, 2011 Dec. PMID 21750967
    3. PRINS Non-Coding RNA Regulates Nucleic Acid-Induced Innate Immune Responses of Human Keratinocytes. Danis J, et al. Front Immunol, 2017. PMID 28900430, Free PMC Article
    4. The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS. Szegedi K, et al. Exp Dermatol, 2010 Mar. PMID 20377629
    5. Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS. Sonkoly E, et al. J Biol Chem, 2005 Jun 24. PMID 15855153

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRINS directly binds to the mRNA of IL-6 through sequence specific binding and leads to the downregulation of IL-6 at mRNA and protein level.
      Title: PRINS Non-Coding RNA Regulates Nucleic Acid-Induced Innate Immune Responses of Human Keratinocytes.
    2. PRINS may play a role in the NPM-mediated cellular stress response in the skin.
      Title: Expression and functional studies on the noncoding RNA, PRINS.
    3. silencing has no effect on LPS-induced NF-kappaB activity in normal human keratinocytes and HaCaT cells
      Title: Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells.
    4. PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations.
      Title: The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS.
    Submit: New GeneRIF Correction

    Variation

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    See variants in ClinVar

    General gene information

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    Markers

    Other Names

    • psoriasis associated RNA induced by stress (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_023388.1: Suppressed sequence

      Description
      NR_023388.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
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