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    STK25 serine/threonine kinase 25 [ Homo sapiens (human) ]

    Gene ID: 10494, updated on 3-Dec-2024

    Summary

    Official Symbol
    STK25provided by HGNC
    Official Full Name
    serine/threonine kinase 25provided by HGNC
    Primary source
    HGNC:HGNC:11404
    See related
    Ensembl:ENSG00000115694 MIM:602255; AllianceGenome:HGNC:11404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SOK1; YSK1
    Summary
    This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in brain (RPKM 17.8), thyroid (RPKM 17.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STK25 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241492670..241509572, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241992007..242008899, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242432085..242448987, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242422458-242422958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242422959-242423459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242429627-242430140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242430141-242430656 Neighboring gene microRNA 3133 Neighboring gene KCTD5 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242445132-242445668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12540 Neighboring gene uncharacterized LOC107985788 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242460159-242460383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12541 Neighboring gene uncharacterized LOC105373974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242486359-242486892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242490880-242491690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12545 Neighboring gene BOK antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242509471-242510095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242515160-242515660 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242518885-242519386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242519387-242519886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242523714-242524242 Neighboring gene BCL2 family apoptosis regulator BOK Neighboring gene RNA, 5S ribosomal pseudogene 122 Neighboring gene THAP domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ43907, DKFZp686J1430

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase 25
    Names
    Ste20, yeast homolog
    ste20-like kinase
    ste20/oxidant stress response kinase 1
    sterile 20/oxidant stress-response kinase 1
    NP_001258906.1
    NP_001258907.1
    NP_001258908.1
    NP_001258909.1
    NP_001269234.1
    NP_001269235.1
    NP_001269236.1
    NP_001269237.1
    NP_006365.2
    XP_011508795.1
    XP_011508796.1
    XP_011508797.1
    XP_011508798.1
    XP_016858659.1
    XP_047298880.1
    XP_047298881.1
    XP_054196157.1
    XP_054196158.1
    XP_054196159.1
    XP_054196160.1
    XP_054196161.1
    XP_054196162.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271977.2NP_001258906.1  serine/threonine-protein kinase 25 isoform 1

      See identical proteins and their annotated locations for NP_001258906.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC110299, BC007852, BC091505, HY315908
      Consensus CDS
      CCDS2549.1
      UniProtKB/Swiss-Prot
      A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1
      UniProtKB/TrEMBL
      A0A024R4B2, A0A0S2Z4Y9, Q96BA2
      Related
      ENSP00000325748.4, ENST00000316586.9
      Conserved Domains (1) summary
      cd06642
      Location:15291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
    2. NM_001271978.2NP_001258907.1  serine/threonine-protein kinase 25 isoform 1

      See identical proteins and their annotated locations for NP_001258907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC110299, BC015793, BU541010, HY315908
      Consensus CDS
      CCDS2549.1
      UniProtKB/Swiss-Prot
      A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1
      UniProtKB/TrEMBL
      A0A024R4B2, A0A0S2Z4Y9, Q96BA2
      Related
      ENSP00000385687.1, ENST00000401869.5
      Conserved Domains (1) summary
      cd06642
      Location:15291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
    3. NM_001271979.2NP_001258908.1  serine/threonine-protein kinase 25 isoform 2

      See identical proteins and their annotated locations for NP_001258908.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. Variants 8 and 9 encode the same isoform (2).
      Source sequence(s)
      AC110299, AK092161, DC353271, HY315908
      Consensus CDS
      CCDS63200.1
      UniProtKB/TrEMBL
      A0A0S2Z4Y2, B3KRS6
      Related
      ENSP00000384444.3, ENST00000405883.7
      Conserved Domains (1) summary
      cl21453
      Location:12214
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001271980.2NP_001258909.1  serine/threonine-protein kinase 25 isoform 2

      See identical proteins and their annotated locations for NP_001258909.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. Variants 8 and 9 encode the same isoform (2).
      Source sequence(s)
      AC110299, AK291808, CB250694, HY315908
      Consensus CDS
      CCDS63200.1
      UniProtKB/TrEMBL
      A0A0S2Z4Y2, B3KRS6
      Related
      ENSP00000385541.1, ENST00000405585.5
      Conserved Domains (1) summary
      cl21453
      Location:12214
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001282305.1NP_001269234.1  serine/threonine-protein kinase 25 isoform 3

      See identical proteins and their annotated locations for NP_001269234.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
      Source sequence(s)
      AC110299, AK303719, CB250694, DA624380, HY315908
      Consensus CDS
      CCDS63199.1
      UniProtKB/TrEMBL
      B4E185
      Related
      ENSP00000444886.1, ENST00000543554.5
      Conserved Domains (1) summary
      cl21453
      Location:1197
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001282306.2NP_001269235.1  serine/threonine-protein kinase 25 isoform 4

      See identical proteins and their annotated locations for NP_001269235.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC110299, AK301214, CB250694, DC353271, HY315908
      UniProtKB/TrEMBL
      B4DVS7, B4E185
      Conserved Domains (2) summary
      smart00220
      Location:16196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16217
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001282307.2NP_001269236.1  serine/threonine-protein kinase 25 isoform 3

      See identical proteins and their annotated locations for NP_001269236.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
      Source sequence(s)
      AC110299, AK297374, BC007852, DC353271, HY315908
      Consensus CDS
      CCDS63199.1
      UniProtKB/TrEMBL
      B4E185
      Related
      ENSP00000446008.1, ENST00000535007.5
      Conserved Domains (1) summary
      cl21453
      Location:1197
      PKc_like; Protein Kinases, catalytic domain
    8. NM_001282308.2NP_001269237.1  serine/threonine-protein kinase 25 isoform 3

      See identical proteins and their annotated locations for NP_001269237.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).
      Source sequence(s)
      AC110299, AK315966, CB250694, HY315908
      Consensus CDS
      CCDS63199.1
      UniProtKB/TrEMBL
      B4E185
      Conserved Domains (1) summary
      cl21453
      Location:1197
      PKc_like; Protein Kinases, catalytic domain
    9. NM_006374.5NP_006365.2  serine/threonine-protein kinase 25 isoform 1

      See identical proteins and their annotated locations for NP_006365.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC110299, BC007852, HY315908
      Consensus CDS
      CCDS2549.1
      UniProtKB/Swiss-Prot
      A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1
      UniProtKB/TrEMBL
      A0A024R4B2, A0A0S2Z4Y9, Q96BA2
      Related
      ENSP00000384162.3, ENST00000403346.7
      Conserved Domains (1) summary
      cd06642
      Location:15291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      241492670..241509572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510495.3XP_011508797.1  serine/threonine-protein kinase 25 isoform X3

      See identical proteins and their annotated locations for XP_011508797.1

      UniProtKB/TrEMBL
      B4DVS7, B4E185
      Conserved Domains (2) summary
      smart00220
      Location:16196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16217
      PKc_like; Protein Kinases, catalytic domain
    2. XM_047442925.1XP_047298881.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7, B4E185
    3. XM_011510494.3XP_011508796.1  serine/threonine-protein kinase 25 isoform X3

      See identical proteins and their annotated locations for XP_011508796.1

      UniProtKB/TrEMBL
      B4DVS7, B4E185
      Conserved Domains (2) summary
      smart00220
      Location:16196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16217
      PKc_like; Protein Kinases, catalytic domain
    4. XM_017003170.2XP_016858659.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7, B4E185
      Conserved Domains (2) summary
      smart00220
      Location:16196
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:16217
      PKc_like; Protein Kinases, catalytic domain
    5. XM_047442924.1XP_047298880.1  serine/threonine-protein kinase 25 isoform X2

    6. XM_011510496.4XP_011508798.1  serine/threonine-protein kinase 25 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:20270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06642
      Location:15291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
    7. XM_011510493.4XP_011508795.1  serine/threonine-protein kinase 25 isoform X1

      UniProtKB/TrEMBL
      Q96BA2
      Conserved Domains (2) summary
      smart00220
      Location:20270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06642
      Location:15291
      STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241992007..242008899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340186.1XP_054196161.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7, B4E185
    2. XM_054340184.1XP_054196159.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7, B4E185
    3. XM_054340185.1XP_054196160.1  serine/threonine-protein kinase 25 isoform X3

      UniProtKB/TrEMBL
      B4DVS7, B4E185
    4. XM_054340183.1XP_054196158.1  serine/threonine-protein kinase 25 isoform X2

    5. XM_054340187.1XP_054196162.1  serine/threonine-protein kinase 25 isoform X4

    6. XM_054340182.1XP_054196157.1  serine/threonine-protein kinase 25 isoform X1

      UniProtKB/TrEMBL
      Q96BA2