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    TYK2 tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 7297, updated on 27-Nov-2024

    Summary

    Official Symbol
    TYK2provided by HGNC
    Official Full Name
    tyrosine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:12440
    See related
    Ensembl:ENSG00000105397 MIM:176941; AllianceGenome:HGNC:12440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JTK1; IMD35
    Summary
    This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in spleen (RPKM 21.6), bone marrow (RPKM 20.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TYK2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10350533..10380572, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10476657..10506988, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10461209..10491248, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10427579-10427770 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10430834-10431047 Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10442682-10443598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10443599-10444515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10445230-10445848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10448906-10449654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13959 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10450403-10451150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10451151-10451898 Neighboring gene intercellular adhesion molecule 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10463923-10464686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10474734-10475234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10491214-10491877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10499431-10499931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10067 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13966 Neighboring gene microRNA 1181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10527911-10528462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10528463-10529013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10530007-10530886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10072 Neighboring gene phosphodiesterase 4A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10542553-10543236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10543237-10543919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10546465-10546964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10572008-10572732

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Immunodeficiency 35
    MedGen: C1969086 OMIM: 611521 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to virus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in interleukin-10-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-12-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-23-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of NK T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NK T cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T-helper 17 type immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of interleukin-17 production NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of natural killer cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in type II interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type III interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    non-receptor tyrosine-protein kinase TYK2
    NP_001372126.1
    NP_001372127.1
    NP_001372128.1
    NP_001372129.1
    NP_001372130.1
    NP_001372131.1
    NP_001372132.1
    NP_001372133.1
    NP_001372134.1
    NP_001372135.1
    NP_001372136.1
    NP_001393390.1
    NP_003322.3
    XP_011526548.1
    XP_011526549.1
    XP_011526551.1
    XP_047295260.1
    XP_047295261.1
    XP_047295262.1
    XP_047295263.1
    XP_054177893.1
    XP_054177894.1
    XP_054177895.1
    XP_054177896.1
    XP_054177897.1
    XP_054177898.1
    XP_054177899.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007872.1 RefSeqGene

      Range
      5001..35045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_121

    mRNA and Protein(s)

    1. NM_001385197.1NP_001372126.1  non-receptor tyrosine-protein kinase TYK2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC011557
      Consensus CDS
      CCDS92513.1
      UniProtKB/TrEMBL
      A0A8E7DA23, H0YE24
      Related
      ENSP00000434831.2, ENST00000525976.6
      Conserved Domains (6) summary
      cd05076
      Location:589867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:8921137
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001385198.1NP_001372127.1  non-receptor tyrosine-protein kinase TYK2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8V8TPJ0
      Conserved Domains (6) summary
      cd05076
      Location:589867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:8921124
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001385199.1NP_001372128.1  non-receptor tyrosine-protein kinase TYK2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05080
      Location:8301112
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:586805
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001385200.1NP_001372129.1  non-receptor tyrosine-protein kinase TYK2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:589866
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:8911173
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
    5. NM_001385201.1NP_001372130.1  non-receptor tyrosine-protein kinase TYK2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:523801
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:8261108
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:371468
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270371
      PH-like; Pleckstrin homology-like domain
    6. NM_001385202.1NP_001372131.1  non-receptor tyrosine-protein kinase TYK2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05080
      Location:8641146
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:589839
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001385203.1NP_001372132.1  non-receptor tyrosine-protein kinase TYK2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:589867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:9191201
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
    8. NM_001385204.1NP_001372133.1  non-receptor tyrosine-protein kinase TYK2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Related
      ENST00000529370.6
      Conserved Domains (6) summary
      cd05080
      Location:9621244
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:589937
      PKc_like; Protein Kinases, catalytic domain
    9. NM_001385205.1NP_001372134.1  non-receptor tyrosine-protein kinase TYK2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:559837
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:8621144
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:255402
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143236
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:407504
      SH2; Src homology 2 (SH2) domain
    10. NM_001385206.1NP_001372135.1  non-receptor tyrosine-protein kinase TYK2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:547825
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:8501132
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437490
      SH2; Src homology 2 (SH2) domain
    11. NM_001385207.1NP_001372136.1  non-receptor tyrosine-protein kinase TYK2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05080
      Location:8861168
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:584861
      PKc_like; Protein Kinases, catalytic domain
    12. NM_001406461.1NP_001393390.1  non-receptor tyrosine-protein kinase TYK2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011557
      Consensus CDS
      CCDS12236.1
      UniProtKB/Swiss-Prot
      P29597, Q6QB10, Q96CH0
      Related
      ENSP00000436175.2, ENST00000531836.7
    13. NM_003331.5NP_003322.3  non-receptor tyrosine-protein kinase TYK2 isoform 2

      See identical proteins and their annotated locations for NP_003322.3

      Status: REVIEWED

      Source sequence(s)
      AK308360, BC014243, DA864169
      Consensus CDS
      CCDS12236.1
      UniProtKB/Swiss-Prot
      P29597, Q6QB10, Q96CH0
      UniProtKB/TrEMBL
      A0A8E7DA23
      Related
      ENSP00000431885.1, ENST00000525621.6
      Conserved Domains (7) summary
      smart00219
      Location:8971169
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:28273
      B41; Band 4.1 homologues
      cd05076
      Location:589867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:8921174
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:589866
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:437534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270437
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10350533..10380572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528246.4XP_011526548.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

      See identical proteins and their annotated locations for XP_011526548.1

      UniProtKB/TrEMBL
      E9PM19
      Conserved Domains (7) summary
      smart00219
      Location:7981070
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:2174
      B41; Band 4.1 homologues
      cd05076
      Location:490768
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:7931075
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:490767
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:338435
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:171338
      PH-like; Pleckstrin homology-like domain
    2. XM_011528247.2XP_011526549.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

      See identical proteins and their annotated locations for XP_011526549.1

      UniProtKB/TrEMBL
      E9PM19
      Related
      ENSP00000433203.1, ENST00000524462.5
      Conserved Domains (7) summary
      smart00219
      Location:7981070
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:2174
      B41; Band 4.1 homologues
      cd05076
      Location:490768
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:7931075
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:490767
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:338435
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:171338
      PH-like; Pleckstrin homology-like domain
    3. XM_011528249.3XP_011526551.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

      Conserved Domains (5) summary
      smart00219
      Location:455727
      TyrKc; Tyrosine kinase, catalytic domain
      cd05076
      Location:147425
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:450732
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:147424
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:1592
      SH2; Src homology 2 (SH2) domain
    4. XM_047439304.1XP_047295260.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    5. XM_047439305.1XP_047295261.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TN50
      Related
      ENSP00000514329.1, ENST00000699358.1
    6. XM_047439306.1XP_047295262.1  non-receptor tyrosine-protein kinase TYK2 isoform X5

      UniProtKB/TrEMBL
      H0YCT7
      Related
      ENSP00000432320.2, ENST00000533334.2
    7. XM_047439307.1XP_047295263.1  non-receptor tyrosine-protein kinase TYK2 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TPX5
      Related
      ENSP00000514328.1, ENST00000699355.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10476657..10506988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321919.1XP_054177894.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    2. XM_054321920.1XP_054177895.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    3. XM_054321922.1XP_054177897.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

    4. XM_054321918.1XP_054177893.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    5. XM_054321921.1XP_054177896.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

    6. XM_054321923.1XP_054177898.1  non-receptor tyrosine-protein kinase TYK2 isoform X5

    7. XM_054321924.1XP_054177899.1  non-receptor tyrosine-protein kinase TYK2 isoform X6