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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_007872.1 RefSeqGene
- Range
-
5001..35045
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_121
mRNA and Protein(s)
-
NM_001385197.1 → NP_001372126.1 non-receptor tyrosine-protein kinase TYK2 isoform 3
Status: REVIEWED
- Source sequence(s)
-
AC011557
- Consensus CDS
-
CCDS92513.1
- UniProtKB/TrEMBL
- A0A8E7DA23, H0YE24
- Related
- ENSP00000434831.2, ENST00000525976.6
- Conserved Domains (6) summary
-
- cd05076
Location:589 → 867
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
- cl21453
Location:892 → 1137
- PKc_like; Protein Kinases, catalytic domain
-
NM_001385198.1 → NP_001372127.1 non-receptor tyrosine-protein kinase TYK2 isoform 4
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8V8TPJ0
- Conserved Domains (6) summary
-
- cd05076
Location:589 → 867
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
- cl21453
Location:892 → 1124
- PKc_like; Protein Kinases, catalytic domain
-
NM_001385199.1 → NP_001372128.1 non-receptor tyrosine-protein kinase TYK2 isoform 5
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Conserved Domains (6) summary
-
- cd05080
Location:830 → 1112
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
- cl21453
Location:586 → 805
- PKc_like; Protein Kinases, catalytic domain
-
NM_001385200.1 → NP_001372129.1 non-receptor tyrosine-protein kinase TYK2 isoform 6
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Conserved Domains (6) summary
-
- cd05076
Location:589 → 866
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:891 → 1173
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
-
NM_001385201.1 → NP_001372130.1 non-receptor tyrosine-protein kinase TYK2 isoform 7
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Conserved Domains (6) summary
-
- cd05076
Location:523 → 801
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:826 → 1108
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:371 → 468
- SH2; Src homology 2 (SH2) domain
- cl17171
Location:270 → 371
- PH-like; Pleckstrin homology-like domain
-
NM_001385202.1 → NP_001372131.1 non-receptor tyrosine-protein kinase TYK2 isoform 8
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Conserved Domains (6) summary
-
- cd05080
Location:864 → 1146
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
- cl21453
Location:589 → 839
- PKc_like; Protein Kinases, catalytic domain
-
NM_001385203.1 → NP_001372132.1 non-receptor tyrosine-protein kinase TYK2 isoform 9
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Conserved Domains (6) summary
-
- cd05076
Location:589 → 867
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:919 → 1201
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
-
NM_001385204.1 → NP_001372133.1 non-receptor tyrosine-protein kinase TYK2 isoform 1
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Related
-
ENST00000529370.6
- Conserved Domains (6) summary
-
- cd05080
Location:962 → 1244
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
- cl21453
Location:589 → 937
- PKc_like; Protein Kinases, catalytic domain
-
NM_001385205.1 → NP_001372134.1 non-receptor tyrosine-protein kinase TYK2 isoform 10
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Conserved Domains (6) summary
-
- cd05076
Location:559 → 837
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:862 → 1144
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:255 → 402
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 236
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:407 → 504
- SH2; Src homology 2 (SH2) domain
-
NM_001385206.1 → NP_001372135.1 non-receptor tyrosine-protein kinase TYK2 isoform 11
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Conserved Domains (6) summary
-
- cd05076
Location:547 → 825
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:850 → 1132
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 490
- SH2; Src homology 2 (SH2) domain
-
NM_001385207.1 → NP_001372136.1 non-receptor tyrosine-protein kinase TYK2 isoform 12
Status: REVIEWED
- Source sequence(s)
-
AC011557
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Conserved Domains (6) summary
-
- cd05080
Location:886 → 1168
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam17887
Location:285 → 432
- Jak1_Phl; Jak1 pleckstrin homology-like domain
- pfam18377
Location:143 → 266
- FERM_F2; FERM F2 acyl-CoA binding protein-like domain
- pfam18379
Location:28 → 125
- FERM_F1; FERM F1 ubiquitin-like domain
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
- cl21453
Location:584 → 861
- PKc_like; Protein Kinases, catalytic domain
-
NM_001406461.1 → NP_001393390.1 non-receptor tyrosine-protein kinase TYK2 isoform 2
Status: REVIEWED
- Source sequence(s)
-
AC011557
- Consensus CDS
-
CCDS12236.1
- UniProtKB/Swiss-Prot
- P29597, Q6QB10, Q96CH0
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Related
- ENSP00000436175.2, ENST00000531836.7
-
NM_003331.5 → NP_003322.3 non-receptor tyrosine-protein kinase TYK2 isoform 2
See identical proteins and their annotated locations for NP_003322.3
Status: REVIEWED
- Source sequence(s)
-
AK308360, BC014243, DA864169
- Consensus CDS
-
CCDS12236.1
- UniProtKB/Swiss-Prot
- P29597, Q6QB10, Q96CH0
- UniProtKB/TrEMBL
-
A0A8E7DA23
- Related
- ENSP00000431885.1, ENST00000525621.6
- Conserved Domains (7) summary
-
- smart00219
Location:897 → 1169
- TyrKc; Tyrosine kinase, catalytic domain
- smart00295
Location:28 → 273
- B41; Band 4.1 homologues
- cd05076
Location:589 → 867
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:892 → 1174
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam07714
Location:589 → 866
- Pkinase_Tyr; Protein tyrosine kinase
- cl15255
Location:437 → 534
- SH2; Src homology 2 (SH2) domain
- cl17171
Location:270 → 437
- PH-like; Pleckstrin homology-like domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000019.10 Reference GRCh38.p14 Primary Assembly
- Range
-
10350533..10380572 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011528246.4 → XP_011526548.1 non-receptor tyrosine-protein kinase TYK2 isoform X2
See identical proteins and their annotated locations for XP_011526548.1
- UniProtKB/TrEMBL
-
E9PM19
- Conserved Domains (7) summary
-
- smart00219
Location:798 → 1070
- TyrKc; Tyrosine kinase, catalytic domain
- smart00295
Location:2 → 174
- B41; Band 4.1 homologues
- cd05076
Location:490 → 768
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:793 → 1075
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam07714
Location:490 → 767
- Pkinase_Tyr; Protein tyrosine kinase
- cl15255
Location:338 → 435
- SH2; Src homology 2 (SH2) domain
- cl17171
Location:171 → 338
- PH-like; Pleckstrin homology-like domain
-
XM_011528247.2 → XP_011526549.1 non-receptor tyrosine-protein kinase TYK2 isoform X2
See identical proteins and their annotated locations for XP_011526549.1
- UniProtKB/TrEMBL
-
E9PM19
- Related
- ENSP00000433203.1, ENST00000524462.5
- Conserved Domains (7) summary
-
- smart00219
Location:798 → 1070
- TyrKc; Tyrosine kinase, catalytic domain
- smart00295
Location:2 → 174
- B41; Band 4.1 homologues
- cd05076
Location:490 → 768
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:793 → 1075
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam07714
Location:490 → 767
- Pkinase_Tyr; Protein tyrosine kinase
- cl15255
Location:338 → 435
- SH2; Src homology 2 (SH2) domain
- cl17171
Location:171 → 338
- PH-like; Pleckstrin homology-like domain
-
XM_011528249.3 → XP_011526551.1 non-receptor tyrosine-protein kinase TYK2 isoform X4
- Conserved Domains (5) summary
-
- smart00219
Location:455 → 727
- TyrKc; Tyrosine kinase, catalytic domain
- cd05076
Location:147 → 425
- PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- cd05080
Location:450 → 732
- PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
- pfam07714
Location:147 → 424
- Pkinase_Tyr; Protein tyrosine kinase
- cl15255
Location:15 → 92
- SH2; Src homology 2 (SH2) domain
-
XM_047439304.1 → XP_047295260.1 non-receptor tyrosine-protein kinase TYK2 isoform X1
- UniProtKB/TrEMBL
-
A0A8E7DA23
-
XM_047439305.1 → XP_047295261.1 non-receptor tyrosine-protein kinase TYK2 isoform X3
- UniProtKB/TrEMBL
- A0A8E7DA23, A0A8V8TN50
- Related
- ENSP00000514329.1, ENST00000699358.1
-
XM_047439306.1 → XP_047295262.1 non-receptor tyrosine-protein kinase TYK2 isoform X5
- UniProtKB/TrEMBL
- H0YCT7, Q53HA9
- Related
- ENSP00000432320.2, ENST00000533334.2
-
XM_047439307.1 → XP_047295263.1 non-receptor tyrosine-protein kinase TYK2 isoform X6
- UniProtKB/TrEMBL
- A0A8V8TPH2, A0A8V8TPX5
- Related
- ENSP00000514328.1, ENST00000699355.1
Alternate T2T-CHM13v2.0
Genomic
-
NC_060943.1 Alternate T2T-CHM13v2.0
- Range
-
10476657..10506988 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054321919.1 → XP_054177894.1 non-receptor tyrosine-protein kinase TYK2 isoform X2
- UniProtKB/TrEMBL
-
E9PM19
-
XM_054321920.1 → XP_054177895.1 non-receptor tyrosine-protein kinase TYK2 isoform X2
- UniProtKB/TrEMBL
-
E9PM19
-
XM_054321922.1 → XP_054177897.1 non-receptor tyrosine-protein kinase TYK2 isoform X4
-
XM_054321918.1 → XP_054177893.1 non-receptor tyrosine-protein kinase TYK2 isoform X1
- UniProtKB/TrEMBL
-
A0A8E7DA23
-
XM_054321921.1 → XP_054177896.1 non-receptor tyrosine-protein kinase TYK2 isoform X3
- UniProtKB/TrEMBL
-
A0A8E7DA23
-
XM_054321923.1 → XP_054177898.1 non-receptor tyrosine-protein kinase TYK2 isoform X5
- UniProtKB/TrEMBL
-
Q53HA9
-
XM_054321924.1 → XP_054177899.1 non-receptor tyrosine-protein kinase TYK2 isoform X6
- UniProtKB/TrEMBL
-
A0A8V8TPH2