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    LGALS2 galectin 2 [ Homo sapiens (human) ]

    Gene ID: 3957, updated on 27-Nov-2024

    Summary

    Official Symbol
    LGALS2provided by HGNC
    Official Full Name
    galectin 2provided by HGNC
    Primary source
    HGNC:HGNC:6562
    See related
    Ensembl:ENSG00000100079 MIM:150571; AllianceGenome:HGNC:6562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HL14
    Summary
    The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in gall bladder (RPKM 133.8), small intestine (RPKM 81.3) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LGALS2 in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37570248..37580087, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38031510..38041349, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37966255..37976094, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37898069-37898668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37898669-37899266 Neighboring gene caspase recruitment domain family member 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37904132-37904960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37904961-37905787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37907945-37908458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37934271-37934772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37934773-37935272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37948043-37948624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37948625-37949206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37957123-37957729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37957730-37958337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37958338-37958944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37959472-37959972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37959973-37960473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37963831-37964482 Neighboring gene HNF1 motif-containing MPRA enhancer 93 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37965972-37966480 Neighboring gene CDC42 effector protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37967120-37967620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37967621-37968121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18977 Neighboring gene Sharpr-MPRA regulatory region 7746 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13688 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38005225-38005846 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38029311-38030184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18984 Neighboring gene Sharpr-MPRA regulatory region 10481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13690 Neighboring gene SH3 domain binding protein 1 Neighboring gene PDXP divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Myocardial infarction, susceptibility to
    MedGen: C1832662 OMIM: 608446 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC75071

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of galectin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    galectin-2
    Names
    S-Lac lectin 2
    beta-galactoside-binding lectin L-14-II
    gal-2
    lactose-binding lectin 2
    lectin, galactoside-binding, soluble, 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012096.1 RefSeqGene

      Range
      4931..14770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006498.3NP_006489.1  galectin-2

      See identical proteins and their annotated locations for NP_006489.1

      Status: REVIEWED

      Source sequence(s)
      AL022315, BC059782, CD701729
      Consensus CDS
      CCDS13950.1
      UniProtKB/Swiss-Prot
      P05162, Q6FGY4
      UniProtKB/TrEMBL
      Q6PIT8
      Related
      ENSP00000215886.4, ENST00000215886.6
      Conserved Domains (1) summary
      cd00070
      Location:11129
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      37570248..37580087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38031510..38041349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)