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    KRBA1 KRAB-A domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 84626, updated on 27-Nov-2024

    Summary

    Official Symbol
    KRBA1provided by HGNC
    Official Full Name
    KRAB-A domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:22228
    See related
    Ensembl:ENSG00000133619 AllianceGenome:HGNC:22228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in regulation of DNA-templated transcription. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart (RPKM 3.8), ovary (RPKM 2.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KRBA1 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149714951..149734575)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150896867..150916494)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149412042..149431664)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tRNA-Cys (anticodon GCA) 17-1 Neighboring gene tRNA-Cys (anticodon GCA) 9-4 Neighboring gene Sharpr-MPRA regulatory region 9729 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149411195-149411694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149412332-149412964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149417350-149418244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149432150-149433066 Neighboring gene uncharacterized LOC124901771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149438995-149439524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149463303-149463978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18768 Neighboring gene zinc finger protein 467 Neighboring gene SCO-spondin, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1862, MGC176633

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029620.2 RefSeqGene

      Range
      5002..24626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290187.2NP_001277116.1  protein KRBA1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AC004897, AL831935, BC142722, BC150330
      Consensus CDS
      CCDS78285.1
      UniProtKB/TrEMBL
      A0A090N8F5, A0A0C4DH65
      Related
      ENSP00000418647.3, ENST00000496259.6
      Conserved Domains (3) summary
      smart00349
      Location:864
      KRAB; krueppel associated box
      pfam01352
      Location:846
      KRAB; KRAB box
      pfam15287
      Location:229271
      KRBA1; KRBA1 family repeat
    2. NM_001394478.1NP_001381407.1  protein KRBA1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      UniProtKB/TrEMBL
      A0A090N8F5
      Conserved Domains (2) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      PHA03247
      Location:128573
      PHA03247; large tegument protein UL36; Provisional
    3. NM_001394479.1NP_001381408.1  protein KRBA1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      UniProtKB/TrEMBL
      A0A090N8F5
      Conserved Domains (1) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    4. NM_001394480.1NP_001381409.1  protein KRBA1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      UniProtKB/TrEMBL
      A0A090N8F5
      Conserved Domains (1) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    5. NM_001394481.1NP_001381410.1  protein KRBA1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      UniProtKB/TrEMBL
      A0A090N8F5
      Conserved Domains (2) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      PHA03247
      Location:113542
      PHA03247; large tegument protein UL36; Provisional
    6. NM_001394482.1NP_001381411.1  protein KRBA1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      UniProtKB/TrEMBL
      A0A090N8F5
      Conserved Domains (1) summary
      PHA03247
      Location:93522
      PHA03247; large tegument protein UL36; Provisional
    7. NM_001394483.1NP_001381412.1  protein KRBA1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      UniProtKB/TrEMBL
      A0A090N8F5
      Conserved Domains (1) summary
      PHA03247
      Location:93522
      PHA03247; large tegument protein UL36; Provisional
    8. NM_001394484.1NP_001381413.1  protein KRBA1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC004897
      UniProtKB/TrEMBL
      A0A090N8F5
      Conserved Domains (2) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      PHA03247
      Location:128586
      PHA03247; large tegument protein UL36; Provisional
    9. NM_001394485.1NP_001381414.1  protein KRBA1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004897
      Consensus CDS
      CCDS94228.1
      UniProtKB/TrEMBL
      A0A090N8F5
      Related
      ENSP00000420112.2, ENST00000485033.6
      Conserved Domains (1) summary
      PHA03247
      Location:341803
      PHA03247; large tegument protein UL36; Provisional
    10. NM_001394486.1NP_001381415.1  protein KRBA1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      Conserved Domains (2) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      PHA03247
      Location:137558
      PHA03247; large tegument protein UL36; Provisional
    11. NM_001394487.1NP_001381416.1  protein KRBA1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      Conserved Domains (2) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      PHA03247
      Location:128557
      PHA03247; large tegument protein UL36; Provisional
    12. NM_001394488.1NP_001381417.1  protein KRBA1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      UniProtKB/TrEMBL
      A0A087WVC5
      Conserved Domains (1) summary
      PHA03247
      Location:78507
      PHA03247; large tegument protein UL36; Provisional
    13. NM_001394489.1NP_001381418.1  protein KRBA1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC004897
      UniProtKB/TrEMBL
      A0A087WVC5
      Conserved Domains (2) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      PHA03247
      Location:123586
      PHA03247; large tegument protein UL36; Provisional
    14. NM_001394490.1NP_001381419.1  protein KRBA1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC004897
      UniProtKB/TrEMBL
      A0A087WVC5
      Related
      ENSP00000479341.1, ENST00000621069.1
      Conserved Domains (2) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      PHA03247
      Location:108571
      PHA03247; large tegument protein UL36; Provisional
    15. NM_001394491.1NP_001381420.1  protein KRBA1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC004897, KF459639
      UniProtKB/TrEMBL
      A0A090N8F5
      Conserved Domains (2) summary
      cd07765
      Location:4482
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      PHA03247
      Location:150579
      PHA03247; large tegument protein UL36; Provisional
    16. NM_001394492.1NP_001381421.1  protein KRBA1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC004897
      UniProtKB/TrEMBL
      A0A087WVC5
    17. NM_001394493.1NP_001381422.1  protein KRBA1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC004897
      Conserved Domains (1) summary
      cd07765
      Location:745
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    18. NM_032534.4NP_115923.2  protein KRBA1 isoform 1

      See identical proteins and their annotated locations for NP_115923.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in its 5' UTR and uses a downstream start codon, compared to variant 2. The encoded isoform (1) has a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AB058765, AC004897, AL831935, BC142722, BC150330
      Consensus CDS
      CCDS75674.1
      UniProtKB/Swiss-Prot
      A5PL33, A7E2F5, E7ENE9, Q8N4X0, Q96JG5
      UniProtKB/TrEMBL
      A0A090N8F5
      Related
      ENSP00000317165.9, ENST00000319551.12
      Conserved Domains (1) summary
      pfam15287
      Location:195237
      KRBA1; KRBA1 family repeat

    RNA

    1. NR_172132.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004897

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149714951..149734575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420964.1XP_047276920.1  protein KRBA1 isoform X1

    2. XM_047420969.1XP_047276925.1  protein KRBA1 isoform X6

    3. XM_047420965.1XP_047276921.1  protein KRBA1 isoform X2

    4. XM_047420970.1XP_047276926.1  protein KRBA1 isoform X7

    5. XM_047420966.1XP_047276922.1  protein KRBA1 isoform X3

    6. XM_047420967.1XP_047276923.1  protein KRBA1 isoform X4

    7. XM_047420968.1XP_047276924.1  protein KRBA1 isoform X5

      UniProtKB/Swiss-Prot
      A5PL33, A7E2F5, E7ENE9, Q8N4X0, Q96JG5
    8. XM_047420971.1XP_047276927.1  protein KRBA1 isoform X8

    9. XM_047420972.1XP_047276928.1  protein KRBA1 isoform X9

    10. XM_047420973.1XP_047276929.1  protein KRBA1 isoform X10

    11. XM_047420974.1XP_047276930.1  protein KRBA1 isoform X11

    12. XM_047420975.1XP_047276931.1  protein KRBA1 isoform X12

    RNA

    1. XR_007060163.1 RNA Sequence

    2. XR_007060164.1 RNA Sequence

    3. XR_007060165.1 RNA Sequence

    4. XR_007060166.1 RNA Sequence

    5. XR_007060167.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150896867..150916494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359236.1XP_054215211.1  protein KRBA1 isoform X1

    2. XM_054359241.1XP_054215216.1  protein KRBA1 isoform X6

    3. XM_054359237.1XP_054215212.1  protein KRBA1 isoform X2

    4. XM_054359242.1XP_054215217.1  protein KRBA1 isoform X7

    5. XM_054359238.1XP_054215213.1  protein KRBA1 isoform X3

    6. XM_054359239.1XP_054215214.1  protein KRBA1 isoform X4

    7. XM_054359240.1XP_054215215.1  protein KRBA1 isoform X5

    8. XM_054359243.1XP_054215218.1  protein KRBA1 isoform X8

    9. XM_054359244.1XP_054215219.1  protein KRBA1 isoform X9

    10. XM_054359245.1XP_054215220.1  protein KRBA1 isoform X10

    11. XM_054359246.1XP_054215221.1  protein KRBA1 isoform X11

    12. XM_054359247.1XP_054215222.1  protein KRBA1 isoform X12

    RNA

    1. XR_008487761.1 RNA Sequence

    2. XR_008487762.1 RNA Sequence

    3. XR_008487763.1 RNA Sequence

    4. XR_008487764.1 RNA Sequence

    5. XR_008487765.1 RNA Sequence