TESK2 testis associated actin remodelling kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TESK2provided by HGNC
Official Full Name: testis associated actin remodelling kinase 2provided by HGNC
Primary source: HGNC:HGNC:11732
See related: Ensembl:ENSG00000070759 MIM:604746; AllianceGenome:HGNC:11732
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression: Broad expression in prostate (RPKM 8.8), testis (RPKM 6.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (45343883..45491163, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (45215440..45362747, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (45809555..45956835, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12.
Title: Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B(12).

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68652 (e-PCR)
- UniSTS:63757

SGC31961 (e-PCR)
- UniSTS:99859

SHGC-149775 (e-PCR)
- UniSTS:177213

TESK2 (e-PCR)
- UniSTS:266341

D1S322 (e-PCR)
- UniSTS:147840

AL033936 (e-PCR)
- UniSTS:93830

Tesk2 (e-PCR), detects polymorphism
- UniSTS:507275

AL033737 (e-PCR)
- UniSTS:93606

RH18295 (e-PCR)
- UniSTS:68777

SHGC-149565 (e-PCR)
- UniSTS:177084

TESK2__5240 (e-PCR)
- UniSTS:464602

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual specificity testis-specific protein kinase 2

Names: testicular protein kinase 2; testis-specific kinase 2

NP_001307729.1

EC 2.7.12.1

NP_009101.2

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320800.2 → NP_001307729.1 dual specificity testis-specific protein kinase 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AB057597, AK294172, AL451136, BC022194, CD367940

UniProtKB/TrEMBL

B4DFN2

Conserved Domains (1) summary

cd14155
Location:1 → 233

PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase
NM_007170.3 → NP_009101.2 dual specificity testis-specific protein kinase 2 isoform 1

See identical proteins and their annotated locations for NP_009101.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AB057597, BC033085, DA990759, DB161528

Consensus CDS

CCDS41323.1

UniProtKB/Swiss-Prot

Q5T422, Q5T423, Q8N520, Q96S53, Q9Y3Q6

UniProtKB/TrEMBL

B4DFN2

Related

ENSP00000361158.3, ENST00000372086.4

Conserved Domains (1) summary

cd14155
Location:64 → 316

PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase