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    Pkdrej polycystin (PKD) family receptor for egg jelly [ Mus musculus (house mouse) ]

    Gene ID: 18766, updated on 9-May-2024

    Summary

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    Official Symbol
    Pkdrejprovided by MGI
    Official Full Name
    polycystin (PKD) family receptor for egg jellyprovided by MGI
    Primary source
    MGI:MGI:1338786
    See related
    Ensembl:ENSMUSG00000052496 AllianceGenome:MGI:1338786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium channel activity. Acts upstream of or within regulation of acrosome reaction. Located in plasma membrane. Is expressed in cochlea. Orthologous to human PKDREJ (polycystin family receptor for egg jelly). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Pkdrej in Genome Data Viewer
    Location:
    15 E2; 15 40.42 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85698877..85705934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85814676..85821733, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10873 Neighboring gene peroxisome proliferator activated receptor alpha Neighboring gene STARR-seq mESC enhancer starr_39399 Neighboring gene STARR-positive B cell enhancer ABC_E5505 Neighboring gene cysteine rich, DPF motif domain containing 1 Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene STARR-seq mESC enhancer starr_39401 Neighboring gene G two S phase expressed protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A polycystin-1 controls postcopulatory reproductive selection in mice. Sutton KA, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18562295, Free PMC Article
    2. Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. Butscheid Y, et al. Mol Reprod Dev, 2006 Mar. PMID 16261614
    3. Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. Hughes J, et al. Hum Mol Genet, 1999 Mar. PMID 9949214
    4. Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. LopezJimenez ND, et al. J Neurochem, 2006 Jul. PMID 16805797
    5. A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. Asai Y, et al. J Assoc Res Otolaryngol, 2010 Mar. PMID 19834762, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polycystin family receptor for egg jelly
    Names
    PKD and REJ homolog
    polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin)
    polycystic kidney disease and receptor for egg jelly-related protein
    receptor for egg jelly-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011105.2 → NP_035235.2  polycystin family receptor for egg jelly precursor

      See identical proteins and their annotated locations for NP_035235.2

      Status: VALIDATED

      Source sequence(s)
      AC117784
      Consensus CDS
      CCDS27723.1
      UniProtKB/Swiss-Prot
      Q9Z0T6
      UniProtKB/TrEMBL
      F8VQF3
      Related
      ENSMUSP00000086352.3, ENSMUST00000064370.6
      Conserved Domains (3) summary
      cd01752
      Location:1115 → 1230
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      pfam02010
      Location:130 → 598
      REJ; REJ domain
      pfam08016
      Location:1621 → 2051
      PKD_channel; Polycystin cation channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      85698877..85705934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0T6.1 GenPept UniProtKB/Swiss-Prot:Q9Z0T6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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