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    Sts steroid sulfatase [ Mus musculus (house mouse) ]

    Gene ID: 20905, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Stsprovided by MGI
    Official Full Name
    steroid sulfataseprovided by MGI
    Primary source
    MGI:MGI:98438
    See related
    AllianceGenome:MGI:98438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ArsC
    Summary
    Predicted to enable arylsulfatase activity and steryl-sulfatase activity. Predicted to be involved in several processes, including response to estrogen; response to pH; and response to peptide hormone. Predicted to act upstream of or within female pregnancy and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; sensory organ; skeleton; skin; and spleen. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human all
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    Genomic context

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    See Sts in Genome Data Viewer
    Location:
    X F5; X
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (168856332..169015037, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene midline 1 Neighboring gene STARR-seq mESC enhancer starr_48290 Neighboring gene predicted gene 15247 Neighboring gene erythroid differentiation regulator 1 x Neighboring gene RIKEN cDNA 2510022D24 gene Neighboring gene neuroligin 4-like Neighboring gene A-kinase anchoring protein 17A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000086.8 Chromosome X Reference GRCm39 C57BL/6J

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene. Mortaud S, et al. Behav Genet, 2010 Mar. PMID 20155394
    2. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Davies W, et al. Biol Psychiatry, 2009 Aug 15. PMID 19251250, Free PMC Article
    3. Expression of steroid sulfatase during embryogenesis. Compagnone NA, et al. Endocrinology, 1997 Nov. PMID 9348204
    4. Murine steroid sulfatase gene expression in the brain during postnatal development and adulthood. Mortaud S, et al. Neurosci Lett, 1996 Sep 13. PMID 8899734
    5. Alleles of the microsomal steroid sulfatase gene (Sts) in the pseudoautosomal region of the heterosomes of the mouse. Roubertoux PL, et al. C R Acad Sci III, 1994 Jun. PMID 7987703

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results revealed an essential role of the adipose STS in energy homeostasis in sex- and sex hormone-dependent manner. Adipose expression of Sts was induced in the high-fat diet (HFD) and ob/ob models of obesity and type 2 diabetes.
      Title: Sex-Dimorphic and Sex Hormone-Dependent Role of Steroid Sulfatase in Adipose Inflammation and Energy Homeostasis.
    2. Overexpression of STS in the liver improved metabolic functions in mouse models of obesity and type 2 diabetes through sex-specific mechanisms.
      Title: Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms.
    3. These data suggest that inactivating mutations and functional variants within STS might exert their influence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic system.
      Title: Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice.
    4. steroid sulfatase may influence core and associated ADHD behavioural endophenotypes via both developmental and ongoing mechanisms, and that the 39,X(Y*)O model may represent a useful tool for elucidating the neurobiological basis of these endophenotypes.
      Title: Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder.
    5. analysis of brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene
      Title: Brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene.
    6. Our data suggest that variation within STS may be particularly associated with the inattentive subtype of ADHD
      Title: Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arylsulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steryl-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfuric ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    steryl-sulfatase
    Names
    ASC
    arylsulfatase C
    steryl-sulfate sulfohydrolase
    NP_033319.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009293.1 → NP_033319.1  steryl-sulfatase precursor

      See identical proteins and their annotated locations for NP_033319.1

      Status: PROVISIONAL

      Source sequence(s)
      U37545
      UniProtKB/Swiss-Prot
      P50427
      Conserved Domains (2) summary
      COG3119
      Location:36 → 530
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cl23718
      Location:36 → 535
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      168856332..169015037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50427.1 GenPept UniProtKB/Swiss-Prot:P50427

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials
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