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    Cstl1 cystatin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 228756, updated on 9-May-2024

    Summary

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    Official Symbol
    Cstl1provided by MGI
    Official Full Name
    cystatin-like 1provided by MGI
    Primary source
    MGI:MGI:2652834
    See related
    Ensembl:ENSMUSG00000055177 AllianceGenome:MGI:2652834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RCET1; RCET2; RCET3
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in testis. Orthologous to human CSTL1 (cystatin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 37.1) See more
    Orthologs
    human all
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    Genomic context

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    See Cstl1 in Genome Data Viewer
    Location:
    2 G3; 2 73.53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148592272..148597354)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148750361..148755434)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:148506639-148506940 Neighboring gene predicted gene, 46771 Neighboring gene GDNF-inducible zinc finger protein 1 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein beta Neighboring gene predicted gene, 54122 Neighboring gene STARR-positive B cell enhancer ABC_E9206 Neighboring gene cystatin 11 Neighboring gene STARR-seq mESC enhancer starr_05977 Neighboring gene cystatin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning, characterization and identification of Rcet1-v1 and Rcet1-v2, two novel splice variants of mouse Rcet1 related to Cres subgroup of family 2 cystatins. Xiang Y, et al. DNA Seq, 2008 Feb. PMID 18300157
    2. A new subgroup of the family 2 cystatins. Cornwall GA, et al. Mol Cell Endocrinol, 2003 Feb 28. PMID 12644294
    3. The reproductive tissue specific cystatin subgroup of genes: expression during gonadal development in wildtype and testatin knockout animals. Frygelius J, et al. Sex Dev, 2007. PMID 18391548
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Primarily expressed in mouse male reproductive tract; may play important roles in mouse spermatocyte and spermatid development.
      Title: Cloning, characterization and identification of Rcet1-v1 and Rcet1-v2, two novel splice variants of mouse Rcet1 related to Cres subgroup of family 2 cystatins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC58781

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signaling receptor ligand precursor processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cystatin-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362207.1 → NP_001349136.1  cystatin-like 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844519
      Consensus CDS
      CCDS89564.1
      UniProtKB/TrEMBL
      A0A2Q2AAE3
      Related
      ENSMUSP00000105580.2, ENSMUST00000109954.8
      Conserved Domains (1) summary
      cl09238
      Location:28 → 86
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

    2. NM_177655.4 → NP_808323.1  cystatin-like 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_808323.1

      Status: VALIDATED

      Source sequence(s)
      AL844519
      Consensus CDS
      CCDS16844.1
      UniProtKB/Swiss-Prot
      Q3V2I7, Q64FK4, Q64FK5, Q80Y72
      Related
      ENSMUSP00000105581.4, ENSMUST00000109955.10
      Conserved Domains (1) summary
      smart00043
      Location:32 → 138
      CY; Cystatin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      148592272..148597354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499302.2 → XP_006499365.1  cystatin-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006499365.1

      UniProtKB/Swiss-Prot
      Q3V2I7, Q64FK4, Q64FK5, Q80Y72
      Conserved Domains (1) summary
      smart00043
      Location:32 → 138
      CY; Cystatin-like domain

    2. XM_006499303.3 → XP_006499366.1  cystatin-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006499366.1

      UniProtKB/Swiss-Prot
      Q3V2I7, Q64FK4, Q64FK5, Q80Y72
      Related
      ENSMUSP00000105578.2, ENSMUST00000109952.2
      Conserved Domains (1) summary
      smart00043
      Location:32 → 138
      CY; Cystatin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y72.1 GenPept UniProtKB/Swiss-Prot:Q80Y72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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