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    CDC25A cell division cycle 25A [ Homo sapiens (human) ]

    Gene ID: 993, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CDC25Aprovided by HGNC
    Official Full Name
    cell division cycle 25Aprovided by HGNC
    Primary source
    HGNC:HGNC:1725
    See related
    Ensembl:ENSG00000164045 MIM:116947; AllianceGenome:HGNC:1725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC25A2
    Summary
    CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 7.4), bone marrow (RPKM 4.6) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDC25A in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48157146..48188417, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48184306..48215830, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48198636..48229907, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 664, pseudogene Neighboring gene MPRA-validated peak4638 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48154883-48155384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48155385-48155884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48157513-48158444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48160097-48160597 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:48164888-48165071 Neighboring gene ribosomal protein L17 pseudogene 16 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:48189821-48190010 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 4 Neighboring gene RNA, U7 small nuclear 128 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48228992-48229620 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48237715-48238244 Neighboring gene microRNA 4443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19825 Neighboring gene Sharpr-MPRA regulatory region 12857 Neighboring gene cathelicidin antimicrobial peptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cdc25A promotes cell survival by stimulating NF-κB activity through IκB-α phosphorylation and destabilization. Hong HY, et al. Biochem Biophys Res Commun, 2012 Apr 6. PMID 22417828
    2. Phosphatases and tumorigenesis. Parsons R. Curr Opin Oncol, 1998 Jan. PMID 9466490
    3. Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Fauman EB, et al. Cell, 1998 May 15. PMID 9604936
    4. The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase. Coqueret O, et al. EMBO J, 1998 Aug 17. PMID 9707427, Free PMC Article
    5. A fission yeast strain expressing human CDC25A phosphatase: a tool for selectivity studies of pharmacological inhibitors of CDC25. Mondesert O, et al. Curr Genet, 2004 May. PMID 14727060

    See all (223) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis.
      Title: Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis.
    2. Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition.
      Title: Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition.
    3. Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.
      Title: Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.
    4. miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest.
      Title: miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest.
    5. Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.
      Title: Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.
    6. FBXW8 regulates G1 and S phases of cell cycle progression by restricting beta-TrCP1 function.
      Title: FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function.
    7. Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
      Title: Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
    8. LINC00662 contributes to the progression and the radioresistance of cervical cancer by regulating miR-497-5p and CDC25A.
      Title: LINC00662 contributes to the progression and the radioresistance of cervical cancer by regulating miR-497-5p and CDC25A.
    9. TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
      Title: TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
    10. HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response.
      Title: HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response.
    Submit: New GeneRIF Correction See all GeneRIFs (123)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25 PubMed
    vpr HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein PubMed
    Vpu vpu HIV-1 Vpu stabilizes cellular Cdc25A and differentially affects betaTrCP-mediated degradation events at different phases of the cell cycle PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA replication TAS
    Traceable Author Statement
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    M-phase inducer phosphatase 1
    Names
    CDC25 homolog A
    dual specificity phosphatase CDC25A
    NP_001780.2
    NP_963861.1
    XP_047305319.1
    XP_047305320.1
    XP_047305321.1
    XP_047305322.1
    XP_047305323.1
    XP_054204613.1
    XP_054204614.1
    XP_054204615.1
    XP_054204616.1
    XP_054204617.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001789.3 → NP_001780.2  M-phase inducer phosphatase 1 isoform a

      See identical proteins and their annotated locations for NP_001780.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC104190, AC124916, AI917350, BC007401, BQ065803, BX392016
      Consensus CDS
      CCDS2760.1
      UniProtKB/Swiss-Prot
      P30304, Q8IZH5, Q96IL3, Q9H2F2
      UniProtKB/TrEMBL
      A8K3D9
      Related
      ENSP00000303706.3, ENST00000302506.8
      Conserved Domains (2) summary
      cd01530
      Location:357 → 475
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:86 → 328
      M-inducer_phosp; M-phase inducer phosphatase

    2. NM_201567.2 → NP_963861.1  M-phase inducer phosphatase 1 isoform b

      See identical proteins and their annotated locations for NP_963861.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC104190, AC124916, AI917350, AY137580, BC007401, BQ065803, BX392016
      Consensus CDS
      CCDS2761.1
      UniProtKB/TrEMBL
      A8K3D9
      Related
      ENSP00000343166.3, ENST00000351231.7
      Conserved Domains (2) summary
      cd01530
      Location:317 → 435
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:86 → 288
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      48157146..48188417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449366.1 → XP_047305322.1  M-phase inducer phosphatase 1 isoform X4

      UniProtKB/TrEMBL
      A8K3D9, D8KXX0

    2. XM_047449364.1 → XP_047305320.1  M-phase inducer phosphatase 1 isoform X2

      UniProtKB/TrEMBL
      A8K3D9, K7N7S0

    3. XM_047449365.1 → XP_047305321.1  M-phase inducer phosphatase 1 isoform X3

      UniProtKB/TrEMBL
      A8K3D9

    4. XM_047449363.1 → XP_047305319.1  M-phase inducer phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      P30304, Q8IZH5, Q96IL3, Q9H2F2
      UniProtKB/TrEMBL
      A8K3D9

    5. XM_047449367.1 → XP_047305323.1  M-phase inducer phosphatase 1 isoform X5

      UniProtKB/TrEMBL
      C9JFR5
      Related
      ENSP00000416483.1, ENST00000443342.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      48184306..48215830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348641.1 → XP_054204616.1  M-phase inducer phosphatase 1 isoform X4

      UniProtKB/TrEMBL
      A8K3D9, D8KXX0

    2. XM_054348639.1 → XP_054204614.1  M-phase inducer phosphatase 1 isoform X2

      UniProtKB/TrEMBL
      A8K3D9, K7N7S0

    3. XM_054348640.1 → XP_054204615.1  M-phase inducer phosphatase 1 isoform X3

      UniProtKB/TrEMBL
      A8K3D9

    4. XM_054348638.1 → XP_054204613.1  M-phase inducer phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      P30304, Q8IZH5, Q96IL3, Q9H2F2
      UniProtKB/TrEMBL
      A8K3D9

    5. XM_054348642.1 → XP_054204617.1  M-phase inducer phosphatase 1 isoform X5

      UniProtKB/TrEMBL
      C9JFR5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30304.2 GenPept UniProtKB/Swiss-Prot:P30304

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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