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    CLASP2 cytoplasmic linker associated protein 2 [ Homo sapiens (human) ]

    Gene ID: 23122, updated on 26-Nov-2024

    Summary

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    Official Symbol
    CLASP2provided by HGNC
    Official Full Name
    cytoplasmic linker associated protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17078
    See related
    Ensembl:ENSG00000163539 MIM:605853; AllianceGenome:HGNC:17078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; focal adhesion; and microtubule cytoskeleton. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 43.5), adrenal (RPKM 10.5) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CLASP2 in Genome Data Viewer
    Location:
    3p22.3
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (33496245..33718254, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (33497978..33719132, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (33537737..33759746, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124909363 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:33487995-33488496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:33489631-33490130 Neighboring gene NANOG hESC enhancer GRCh37_chr3:33504525-33505078 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:33508920-33510119 Neighboring gene RNA, 5S ribosomal pseudogene 128 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 10 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:33618786-33619296 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:33619297-33619807 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:33620187-33620768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19650 Neighboring gene MPRA-validated peak4600 silencer Neighboring gene MPRA-validated peak4601 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14192 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:33830741-33831638 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:33840285-33840818 Neighboring gene SDA1 domain containing 1 pseudogene 3 Neighboring gene PDCD6IP divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human CLASP2 specifically regulates microtubule catastrophe and rescue. Lawrence EJ, et al. Mol Biol Cell, 2018 May 15. PMID 29540526, Free PMC Article
    2. HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus. Mitra S, et al. J Virol, 2020 Jul 1. PMID 32376623, Free PMC Article
    3. Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. Wittmann T, et al. J Cell Biol, 2005 Jun 20. PMID 15955847, Free PMC Article
    4. CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation. Aher A, et al. Curr Biol, 2020 Jun 8. PMID 32359430, Free PMC Article
    5. CLASP2 facilitates dynamic actin filament organization along the microtubule lattice. Rodgers NC, et al. Mol Biol Cell, 2023 Mar 1. PMID 36598814, Free PMC Article

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLASP2 facilitates dynamic actin filament organization along the microtubule lattice.
      Title: CLASP2 facilitates dynamic actin filament organization along the microtubule lattice.
    2. CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner.
      Title: CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner.
    3. Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3beta and CK1delta regulates EB1-dependent MT dynamics in cell migration.
      Title: Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration.
    4. SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.
      Title: SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.
    5. CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation.
      Title: CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation.
    6. HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus.
      Title: HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus.
    7. Significance of CLASP2 expression in prognosis for muscle-invasive bladder cancer patients: A propensity score-based analysis.
      Title: Significance of CLASP2 expression in prognosis for muscle-invasive bladder cancer patients: A propensity score-based analysis.
    8. CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments.
      Title: CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments.
    9. microtubules grown with CLASP2 display greater variability in growth rates.
      Title: Human CLASP2 specifically regulates microtubule catastrophe and rescue.
    10. CLASP2 is involved in the epithelial-mesenchymal transition and progression of bladder urothelial cancer. Simultaneous urine-based detection of CLASP2 and E-cadherin mRNA can efficiently discriminate patients with or without 2-years progression after transurethral resection of the bladder tumor.
      Title: CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dystroglycan binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule organizing center organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of wound healing, spreading of epidermal cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in platelet-derived growth factor receptor-beta signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of microtubule polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basal cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    colocalizes_with kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in kinetochore microtubule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with mitotic spindle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CLIP-associating protein 2
    Names
    CLIP-associating protein CLASP2
    multiple asters (Mast)-like homolog 2
    protein Orbit homolog 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001207044.3 → NP_001193973.1  CLIP-associating protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001193973.1

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      Consensus CDS
      CCDS93234.1
      UniProtKB/Swiss-Prot
      B2RTR1, F5H604, O75122, Q7L8F6, Q8N6R6, Q9BQT3, Q9BQT4, Q9H7A3, Q9NSZ2
      UniProtKB/TrEMBL
      E3W994
      Related
      ENSP00000417518.2, ENST00000480013.6
      Conserved Domains (2) summary
      sd00044
      Location:655 → 682
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:94 → 305
      CLASP_N; CLASP N terminal

    2. NM_001365627.1 → NP_001352556.1  CLIP-associating protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    3. NM_001365628.1 → NP_001352557.1  CLIP-associating protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal

    4. NM_001365629.1 → NP_001352558.1  CLIP-associating protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    5. NM_001365630.1 → NP_001352559.1  CLIP-associating protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    6. NM_001365631.1 → NP_001352560.1  CLIP-associating protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      Consensus CDS
      CCDS93235.1
      UniProtKB/TrEMBL
      A0A804HJG7, E3W994
      Related
      ENSP00000507498.1, ENST00000682230.1
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    7. NM_001365632.1 → NP_001352561.1  CLIP-associating protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    8. NM_001365633.1 → NP_001352562.1  CLIP-associating protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal

    9. NM_001365634.1 → NP_001352563.1  CLIP-associating protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    10. NM_001375694.1 → NP_001362623.1  CLIP-associating protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (4) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal
      cl41918
      Location:671 → 759
      CoV_N-NTD; N-terminal domain of nucleocapsid (N) protein of coronavirus

    11. NM_001375697.1 → NP_001362626.1  CLIP-associating protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    12. NM_001375700.1 → NP_001362629.1  CLIP-associating protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (4) summary
      PHA03307
      Location:570 → 786
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    13. NM_001375701.1 → NP_001362630.1  CLIP-associating protein 2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      Consensus CDS
      CCDS93237.1
      UniProtKB/TrEMBL
      E3W994, E7EW49
      Related
      ENSP00000419974.2, ENST00000468888.6
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal

    14. NM_001375703.1 → NP_001362632.1  CLIP-associating protein 2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal

    15. NM_001375705.1 → NP_001362634.1  CLIP-associating protein 2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (4) summary
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal
      cl41918
      Location:657 → 745
      CoV_N-NTD; N-terminal domain of nucleocapsid (N) protein of coronavirus

    16. NM_001375713.1 → NP_001362642.1  CLIP-associating protein 2 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      sd00044
      Location:32 → 58
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:69 → 99
      HEAT; HEAT repeat
      pfam12348
      Location:228 → 439
      CLASP_N; CLASP N terminal

    17. NM_001375715.1 → NP_001362644.1  CLIP-associating protein 2 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (2) summary
      sd00044
      Location:1059 → 1081
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:94 → 305
      CLASP_N; CLASP N terminal

    18. NM_001375716.1 → NP_001362645.1  CLIP-associating protein 2 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (2) summary
      sd00044
      Location:641 → 668
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:101 → 312
      CLASP_N; CLASP N terminal

    19. NM_001375718.1 → NP_001362647.1  CLIP-associating protein 2 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (2) summary
      sd00044
      Location:640 → 667
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:100 → 311
      CLASP_N; CLASP N terminal

    20. NM_001375720.1 → NP_001362649.1  CLIP-associating protein 2 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Related
      ENSP00000419305.3, ENST00000461133.8
      Conserved Domains (2) summary
      sd00044
      Location:634 → 661
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:94 → 305
      CLASP_N; CLASP N terminal

    21. NM_001400405.1 → NP_001387334.1  CLIP-associating protein 2 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    22. NM_001400406.1 → NP_001387335.1  CLIP-associating protein 2 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    23. NM_001400407.1 → NP_001387336.1  CLIP-associating protein 2 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    24. NM_001400408.1 → NP_001387337.1  CLIP-associating protein 2 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    25. NM_001400409.1 → NP_001387338.1  CLIP-associating protein 2 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    26. NM_001400410.1 → NP_001387339.1  CLIP-associating protein 2 isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    27. NM_001400411.1 → NP_001387340.1  CLIP-associating protein 2 isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    28. NM_001400412.1 → NP_001387341.1  CLIP-associating protein 2 isoform 29

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    29. NM_001400413.1 → NP_001387342.1  CLIP-associating protein 2 isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    30. NM_001400414.1 → NP_001387343.1  CLIP-associating protein 2 isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      Consensus CDS
      CCDS93232.1
      UniProtKB/TrEMBL
      A0A0U1RQI6
      Related
      ENSP00000489023.1, ENST00000635664.1

    31. NM_001400415.1 → NP_001387344.1  CLIP-associating protein 2 isoform 32

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    32. NM_001400416.1 → NP_001387345.1  CLIP-associating protein 2 isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    33. NM_001400417.1 → NP_001387346.1  CLIP-associating protein 2 isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    34. NM_001400418.1 → NP_001387347.1  CLIP-associating protein 2 isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    35. NM_001400419.1 → NP_001387348.1  CLIP-associating protein 2 isoform 35

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    36. NM_001400420.1 → NP_001387349.1  CLIP-associating protein 2 isoform 36

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    37. NM_001400421.1 → NP_001387350.1  CLIP-associating protein 2 isoform 37

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    38. NM_001400422.1 → NP_001387351.1  CLIP-associating protein 2 isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    39. NM_001400423.1 → NP_001387352.1  CLIP-associating protein 2 isoform 39

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    40. NM_001400424.1 → NP_001387353.1  CLIP-associating protein 2 isoform 40

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    41. NM_001400425.1 → NP_001387354.1  CLIP-associating protein 2 isoform 41

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      Consensus CDS
      CCDS93233.1
      UniProtKB/TrEMBL
      J3KR49
      Related
      ENSP00000498272.1, ENST00000650653.1

    42. NM_001400427.1 → NP_001387356.1  CLIP-associating protein 2 isoform 42

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    43. NM_001400428.1 → NP_001387357.1  CLIP-associating protein 2 isoform 43

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    44. NM_001400429.1 → NP_001387358.1  CLIP-associating protein 2 isoform 44

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    45. NM_001400430.1 → NP_001387359.1  CLIP-associating protein 2 isoform 45

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    46. NM_001400431.1 → NP_001387360.1  CLIP-associating protein 2 isoform 46

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    47. NM_001400432.1 → NP_001387361.1  CLIP-associating protein 2 isoform 47

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    48. NM_001400433.1 → NP_001387362.1  CLIP-associating protein 2 isoform 48

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    49. NM_001400434.1 → NP_001387363.1  CLIP-associating protein 2 isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    50. NM_001400435.1 → NP_001387364.1  CLIP-associating protein 2 isoform 50

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    51. NM_001400436.1 → NP_001387365.1  CLIP-associating protein 2 isoform 51

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    52. NM_001400437.1 → NP_001387366.1  CLIP-associating protein 2 isoform 52

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515

    53. NM_015097.3 → NP_055912.2  CLIP-associating protein 2 isoform 1

      See identical proteins and their annotated locations for NP_055912.2

      Status: VALIDATED

      Source sequence(s)
      AC093114, AC113170, AC132515
      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      33496245..33718254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447759.1 → XP_047303715.1  CLIP-associating protein 2 isoform X16

    2. XM_017005949.2 → XP_016861438.1  CLIP-associating protein 2 isoform X8

      UniProtKB/TrEMBL
      E3W994

    3. XM_047447757.1 → XP_047303713.1  CLIP-associating protein 2 isoform X14

    4. XM_047447756.1 → XP_047303712.1  CLIP-associating protein 2 isoform X12

    5. XM_017005959.2 → XP_016861448.1  CLIP-associating protein 2 isoform X19

      UniProtKB/TrEMBL
      E3W994, E7ERI8
      Related
      ENSP00000382297.4, ENST00000399362.8

    6. XM_006713052.2 → XP_006713115.1  CLIP-associating protein 2 isoform X17

      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    7. XM_017005948.2 → XP_016861437.1  CLIP-associating protein 2 isoform X6

      UniProtKB/TrEMBL
      E3W994

    8. XM_006713041.2 → XP_006713104.1  CLIP-associating protein 2 isoform X4

      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (4) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam10265
      Location:686 → 790
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    9. XM_047447755.1 → XP_047303711.1  CLIP-associating protein 2 isoform X2

    10. XM_047447761.1 → XP_047303717.1  CLIP-associating protein 2 isoform X21

    11. XM_017005960.2 → XP_016861449.1  CLIP-associating protein 2 isoform X20

      UniProtKB/TrEMBL
      E3W994

    12. XM_047447758.1 → XP_047303714.1  CLIP-associating protein 2 isoform X15

    13. XM_047447760.1 → XP_047303716.1  CLIP-associating protein 2 isoform X18

    14. XM_011533515.2 → XP_011531817.1  CLIP-associating protein 2 isoform X7

      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (4) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam10265
      Location:673 → 777
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    15. XM_017005957.2 → XP_016861446.1  CLIP-associating protein 2 isoform X13

      UniProtKB/TrEMBL
      E3W994

    16. XM_006713053.2 → XP_006713116.1  CLIP-associating protein 2 isoform X22

      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    17. XM_006713050.2 → XP_006713113.1  CLIP-associating protein 2 isoform X11

      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    18. XM_006713048.2 → XP_006713111.1  CLIP-associating protein 2 isoform X9

      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (3) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    19. XM_017005956.2 → XP_016861445.1  CLIP-associating protein 2 isoform X10

      UniProtKB/TrEMBL
      E3W994

    20. XM_006713042.2 → XP_006713105.1  CLIP-associating protein 2 isoform X5

      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (4) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam10265
      Location:687 → 791
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    21. XM_006713040.2 → XP_006713103.1  CLIP-associating protein 2 isoform X3

      UniProtKB/TrEMBL
      E3W994
      Conserved Domains (4) summary
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam10265
      Location:687 → 791
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:328 → 539
      CLASP_N; CLASP N terminal
      sd00044
      Location:131 → 157
      HEAT; HEAT repeat [structural motif]

    22. XM_047447754.1 → XP_047303710.1  CLIP-associating protein 2 isoform X1

    23. XM_047447764.1 → XP_047303720.1  CLIP-associating protein 2 isoform X28

    24. XM_017005972.3 → XP_016861461.1  CLIP-associating protein 2 isoform X25

      UniProtKB/TrEMBL
      E3W994

    25. XM_047447763.1 → XP_047303719.1  CLIP-associating protein 2 isoform X27

    26. XM_047447762.1 → XP_047303718.1  CLIP-associating protein 2 isoform X26

    27. XM_017005969.3 → XP_016861458.1  CLIP-associating protein 2 isoform X24

      UniProtKB/TrEMBL
      E3W994

    28. XM_017005968.3 → XP_016861457.1  CLIP-associating protein 2 isoform X23

      UniProtKB/TrEMBL
      E3W994

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      33497978..33719132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345779.1 → XP_054201754.1  CLIP-associating protein 2 isoform X16

    2. XM_054345771.1 → XP_054201746.1  CLIP-associating protein 2 isoform X8

    3. XM_054345777.1 → XP_054201752.1  CLIP-associating protein 2 isoform X14

    4. XM_054345775.1 → XP_054201750.1  CLIP-associating protein 2 isoform X12

    5. XM_054345782.1 → XP_054201757.1  CLIP-associating protein 2 isoform X19

      UniProtKB/TrEMBL
      E7ERI8

    6. XM_054345780.1 → XP_054201755.1  CLIP-associating protein 2 isoform X17

    7. XM_054345769.1 → XP_054201744.1  CLIP-associating protein 2 isoform X6

    8. XM_054345767.1 → XP_054201742.1  CLIP-associating protein 2 isoform X4

    9. XM_054345765.1 → XP_054201740.1  CLIP-associating protein 2 isoform X2

    10. XM_054345784.1 → XP_054201759.1  CLIP-associating protein 2 isoform X21

    11. XM_054345783.1 → XP_054201758.1  CLIP-associating protein 2 isoform X20

    12. XM_054345778.1 → XP_054201753.1  CLIP-associating protein 2 isoform X15

    13. XM_054345781.1 → XP_054201756.1  CLIP-associating protein 2 isoform X18

    14. XM_054345770.1 → XP_054201745.1  CLIP-associating protein 2 isoform X7

    15. XM_054345776.1 → XP_054201751.1  CLIP-associating protein 2 isoform X13

    16. XM_054345785.1 → XP_054201760.1  CLIP-associating protein 2 isoform X22

    17. XM_054345774.1 → XP_054201749.1  CLIP-associating protein 2 isoform X11

    18. XM_054345772.1 → XP_054201747.1  CLIP-associating protein 2 isoform X9

    19. XM_054345773.1 → XP_054201748.1  CLIP-associating protein 2 isoform X10

    20. XM_054345768.1 → XP_054201743.1  CLIP-associating protein 2 isoform X5

    21. XM_054345766.1 → XP_054201741.1  CLIP-associating protein 2 isoform X3

    22. XM_054345764.1 → XP_054201739.1  CLIP-associating protein 2 isoform X1

    23. XM_054345791.1 → XP_054201766.1  CLIP-associating protein 2 isoform X28

    24. XM_054345788.1 → XP_054201763.1  CLIP-associating protein 2 isoform X25

    25. XM_054345790.1 → XP_054201765.1  CLIP-associating protein 2 isoform X27

    26. XM_054345789.1 → XP_054201764.1  CLIP-associating protein 2 isoform X26

    27. XM_054345787.1 → XP_054201762.1  CLIP-associating protein 2 isoform X24

    28. XM_054345786.1 → XP_054201761.1  CLIP-associating protein 2 isoform X23

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75122.3 GenPept UniProtKB/Swiss-Prot:O75122

    Gene LinkOut

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