CYP4F11 cytochrome P450 family 4 subfamily F member 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP4F11provided by HGNC
Official Full Name: cytochrome P450 family 4 subfamily F member 11provided by HGNC
Primary source: HGNC:HGNC:13265
See related: Ensembl:ENSG00000171903 MIM:611517; AllianceGenome:HGNC:13265
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CYPIVF11
Summary: This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver (RPKM 19.6), gall bladder (RPKM 11.3) and 11 other tissues See more
Orthologs: all
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Genomic context

Location:: 19p13.12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (15912377..15934867, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (16043606..16068596, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (16023187..16045677, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deciphering the Role of Fatty Acid-Metabolizing CYP4F11 in Lung Cancer and Its Potential As a Drug Target.
Title: Deciphering the Role of Fatty Acid-Metabolizing CYP4F11 in Lung Cancer and Its Potential As a Drug Target.
A novel gene associated with small bowel bleeding in patients taking low-dose aspirin.
Title: A novel gene associated with small bowel bleeding in patients taking low-dose aspirin.
Regulation of cytochrome P450 4F11 expression by liver X receptor alpha.
Title: Regulation of cytochrome P450 4F11 expression by liver X receptor alpha.
results suggest that the metabolism of CYP4F11 substrates may be reduced in individuals carrying the CYP4F11 D315N genetic variant and individuals carrying the common D446N CYP4F11 variant likely exhibit comparable 20-HETE synthesis as individuals expressing wild-type CYP4F11.
Title: Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis.
Microsomal menaquinone-4 omega-hydroxylation activities correlated with the CYP4F2 V433M genotype but not the CYP4F11 D446N genotype
Title: Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The CYP4F11 gene is positively regulated by multiple signaling pathways in HaCaT keratinocytes, including retinoid X receptor and JNK signaling pathways.
Title: Gene regulation of CYP4F11 in human keratinocyte HaCaT cells.
3-hydroxystearate and 3-hydroxypalmitate are converted to omega-hydroxylated 3-OHDCA precursors in liver; CYP4F11 and, to a lesser extent, CYP4F2 catalyzed omega-hydroxylation of 3-hydroxystearate; CYP4F3b, CYP4F12, and CYP4A11 had negligible activity.
Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of cytochrome P450, family 4, subfamily F, polypeptide 11 (CYP4F11) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G15996 (e-PCR)
- UniSTS:59970

RH123595 (e-PCR)
- UniSTS:136015

GDB:182516 (e-PCR)
- UniSTS:155384

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables arachidonate omega-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	TAS Traceable Author Statement more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in cytochrome metabolic process	TAS Traceable Author Statement more info
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in menaquinone catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in menaquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in omega-hydroxylase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in oxylipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phylloquinone catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phylloquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phylloquinone catabolic process	IEA Inferred from Electronic Annotation more info
involved_in vitamin K catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cytochrome P450 4F11

Names: 3-hydroxy fatty acids omega-hydroxylase CYP4F11; cytochrome P450, family 4, subfamily F, polypeptide 11; cytochrome P450, subfamily IVF, polypeptide 11; docosahexaenoic acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase; phylloquinone omega-hydroxylase CYP4F11

NP_001122404.1

EC 1.14.14.1

EC 1.14.14.78

EC 1.14.14.79

EC 1.14.14.80

NP_067010.3

EC 1.14.14.1

EC 1.14.14.78

EC 1.14.14.79

EC 1.14.14.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.