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    GPR174 G protein-coupled receptor 174 [ Homo sapiens (human) ]

    Gene ID: 84636, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR174provided by HGNC
    Official Full Name
    G protein-coupled receptor 174provided by HGNC
    Primary source
    HGNC:HGNC:30245
    See related
    Ensembl:ENSG00000147138 MIM:300903; AllianceGenome:HGNC:30245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPS3; FKSG79; GPCR17; LYPSR3
    Summary
    This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]
    Orthologs
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    Genomic context

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    See GPR174 in Genome Data Viewer
    Location:
    Xq21.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (79144688..79175318)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (77581427..77612052)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (78400185..78430815)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene P2Y receptor family member 10 Neighboring gene P2Y receptor family member 10B, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:78385499-78386160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29789 Neighboring gene collagen triple helix repeat containing 1 pseudogene 1 Neighboring gene kinesin family member 4C, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation. Liang J, et al. Nat Commun, 2023 Feb 23. PMID 36823105, Free PMC Article
    2. Gpr174 Knockout Alleviates DSS-Induced Colitis via Regulating the Immune Function of Dendritic Cells. Wei W, et al. Front Immunol, 2022. PMID 35669778, Free PMC Article
    3. Lysophosphatidylserine analogues differentially activate three LysoPS receptors. Uwamizu A, et al. J Biochem, 2015 Mar. PMID 25320102
    4. rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population. Szymański K, et al. Tissue Antigens, 2014 Jan. PMID 24289805
    5. An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease. Chu X, et al. J Med Genet, 2013 Jul. PMID 23667180, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
      Title: Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
    2. Gpr174 Knockout Alleviates DSS-Induced Colitis via Regulating the Immune Function of Dendritic Cells.
      Title: Gpr174 Knockout Alleviates DSS-Induced Colitis via Regulating the Immune Function of Dendritic Cells.
    3. GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response.
      Title: GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response.
    4. GPR174 and ITM2A Gene Polymorphisms rs3827440 and rs5912838 on the X chromosome in Korean Children with Autoimmune Thyroid Disease.
      Title: GPR174 and ITM2A Gene Polymorphisms rs3827440 and rs5912838 on the X chromosome in Korean Children with Autoimmune Thyroid Disease.
    5. Studied association of and RNASET2, GPR174, and PTPN22 gene polymorphisms and liver damage(LD) due to Graves' disease (GD) hyperthyroidism. Found GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 were significantly associated with altered GD-derived LD risk.
      Title: RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
    6. Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
      Title: Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
    7. We have demonstrated a significant association of this X chromosome-encoded immunoreceptor with autoimmune Addison's disease for the first time.
      Title: Role of the X-linked gene GPR174 in autoimmune Addison's disease.
    8. this study provides the first replication in a Caucasian population of the association between Graves' disease and the GPR174 rs3827440 single nucleotide polymorphism originally reported among Chinese.
      Title: rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population.
    9. The finding of an X-linked risk locus for Graves' disease expands our understanding of the role of the X chromosome in disease susceptibility.
      Title: An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease.
    10. These results suggested that GPR174 was a putative LysoPS receptor conjugating with Galpha(s), and its expression induced morphological changes in CHO cells by constitutively activating adenylyl cycles accompanied with cell conjunctions and delay of proliferation.
      Title: Expression of orphan G-protein coupled receptor GPR174 in CHO cells induced morphological changes and proliferation delay via increasing intracellular cAMP.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bioactive lipid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 174
    Names
    lysophosphatidylserine receptor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016565.2 RefSeqGene

      Range
      5001..9347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032553.3 → NP_115942.1  probable G-protein coupled receptor 174

      See identical proteins and their annotated locations for NP_115942.1

      Status: VALIDATED

      Source sequence(s)
      AL590222
      Consensus CDS
      CCDS14443.1
      UniProtKB/Swiss-Prot
      Q2M3F7, Q9BXC1
      Related
      ENSP00000494310.1, ENST00000645147.2
      Conserved Domains (1) summary
      pfam00001
      Location:36 → 292
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      79144688..79175318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442580.1 → XP_047298536.1  probable G-protein coupled receptor 174 isoform X1

      UniProtKB/Swiss-Prot
      Q2M3F7, Q9BXC1

    2. XM_047442579.1 → XP_047298535.1  probable G-protein coupled receptor 174 isoform X1

      UniProtKB/Swiss-Prot
      Q2M3F7, Q9BXC1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      77581427..77612052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327992.1 → XP_054183967.1  probable G-protein coupled receptor 174 isoform X1

    2. XM_054327991.1 → XP_054183966.1  probable G-protein coupled receptor 174 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXC1.1 GenPept UniProtKB/Swiss-Prot:Q9BXC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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