SENCR smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: SENCRprovided by HGNC
Official Full Name: smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNAprovided by HGNC
Primary source: HGNC:HGNC:44177
See related: Ensembl:ENSG00000254703 MIM:615815; AllianceGenome:HGNC:44177
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: lncRNA9; FLI1-AS1
Expression: Broad expression in spleen (RPKM 2.6), placenta (RPKM 0.7) and 16 other tissues See more
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Genomic context

Location:: 11q24.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (128691672..128696023, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (128724900..128729224, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (128561567..128565918, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The relationship between preeclampsia risk and SENCR rs555172 gene polymorphism and expression.
Title: The relationship between preeclampsia risk and SENCR rs555172 gene polymorphism and expression.
Super enhancer-LncRNA SENCR promoted cisplatin resistance and growth of NSCLC through upregulating FLI1.
Title: Super enhancer-LncRNA SENCR promoted cisplatin resistance and growth of NSCLC through upregulating FLI1.
LncRNA SENCR overexpression attenuated the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection via the miR-206/myocardin axis.
Title: LncRNA SENCR overexpression attenuated the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection via the miR-206/myocardin axis.
Preliminary study on the mechanism of long noncoding RNA SENCR regulating the proliferation and migration of vascular smooth muscle cells.
Title: Preliminary study on the mechanism of long noncoding RNA SENCR regulating the proliferation and migration of vascular smooth muscle cells.
These findings support SENCR as a flow-responsive lncRNA that promotes EC adherens junction integrity through physical association with CKAP4, thereby stabilizing cell membrane-bound CDH5.
Title: SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4.
Long non-coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells.
Title: Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells.
Data showed that SENCR contributes to the regulation of endothelial differentiation from pluripotent cells and controls the angiogenic capacity of human umbilical endothelial cells.
Title: A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

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General gene information

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Markers

RH103284 (e-PCR)
- UniSTS:97615

STS-R74314 (e-PCR)
- UniSTS:42729

Other Names

FLI1 antisense RNA 1 (non-protein coding)
smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.