MLST8 MTOR associated protein, LST8 homolog [Homo sapiens (human)] - Gene

Summary

Official Symbol: MLST8provided by HGNC
Official Full Name: MTOR associated protein, LST8 homologprovided by HGNC
Primary source: HGNC:HGNC:24825
See related: Ensembl:ENSG00000167965 MIM:612190; AllianceGenome:HGNC:24825
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GBL; LST8; POP3; WAT1; GbetaL
Summary: Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis (RPKM 10.4), brain (RPKM 8.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (2205454..2209453)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (2227913..2231910)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (2255455..2259454)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m(6)A demethylation of EIF4EBP1 and MLST8 mRNA.
Title: Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m(6)A demethylation of EIF4EBP1 and MLST8 mRNA.
CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.
Title: CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.
STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells.
Title: STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells.
ASO Author Reflections: mLST8 is a Prognostic Biomarker and Involved in Tumor Progression in Hepatocellular Carcinoma.
Title: ASO Author Reflections: mLST8 is a Prognostic Biomarker and Involved in Tumor Progression in Hepatocellular Carcinoma.
Enhanced mLST8 Expression Correlates with Tumor Progression in Hepatocellular Carcinoma.
Title: Enhanced mLST8 Expression Correlates with Tumor Progression in Hepatocellular Carcinoma.
NEAT1 was potentially communicated with mTOR signaling target protein mLST8 via the association with miR-181b in type 2 diabetes mellitus.
Title: Construction of competitive endogenous RNA network reveals regulatory role of long non-coding RNAs in type 2 diabetes mellitus.
Autophagy regulates c-MET phosphorylation via an mTORC2-dependent mechanism.
Title: mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.
Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus.
Title: The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.
MLST8 upregulation may contribute to tumor progression.
Title: mLST8 Promotes mTOR-Mediated Tumor Progression.
Amino acids promote mTORC1 activation without altering Rag GTP charging.
Title: Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	NAS Non-traceable Author Statement more info	PubMed
involved_in TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to osmotic stress	NAS Non-traceable Author Statement more info	PubMed
involved_in cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of autophagy	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of glycolytic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of lipid biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of pentose-phosphate shunt	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: target of rapamycin complex subunit LST8

Names: TORC subunit LST8; gable; mammalian lethal with SEC13 protein 8; protein GbetaL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199173.3 → NP_001186102.1 target of rapamycin complex subunit LST8 isoform a

See identical proteins and their annotated locations for NP_001186102.1

Status: VALIDATED

Source sequence(s)

AC009065, AK021536, AK098762

Consensus CDS

CCDS10462.2

UniProtKB/Swiss-Prot

B3KMM4, B4DY00, D3DU88, Q5M800, Q86Y18, Q8WUI5, Q9BVC4, Q9HA66, Q9UJV6

UniProtKB/TrEMBL

H3BSZ4

Related

ENSP00000457870.1, ENST00000564088.5

Conserved Domains (2) summary

cd00200
Location:14 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:47 → 83

7WD40; WD40 repeat [structural motif]
NM_001199174.3 → NP_001186103.1 target of rapamycin complex subunit LST8 isoform a

See identical proteins and their annotated locations for NP_001186103.1

Status: VALIDATED

Source sequence(s)

AC009065

Consensus CDS

CCDS10462.2

UniProtKB/Swiss-Prot

B3KMM4, B4DY00, D3DU88, Q5M800, Q86Y18, Q8WUI5, Q9BVC4, Q9HA66, Q9UJV6

UniProtKB/TrEMBL

H3BSZ4

Related

ENSP00000380313.1, ENST00000397124.5

Conserved Domains (2) summary

cd00200
Location:14 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:47 → 83

7WD40; WD40 repeat [structural motif]
NM_001199175.3 → NP_001186104.1 target of rapamycin complex subunit LST8 isoform b

See identical proteins and their annotated locations for NP_001186104.1

Status: VALIDATED

Source sequence(s)

AC009065, AK021536, AK098762, BC088354

Consensus CDS

CCDS58409.1

UniProtKB/TrEMBL

H3BSZ4

Related

ENSP00000371888.4, ENST00000382450.8

Conserved Domains (3) summary

COG2319
Location:10 → 319

WD40; WD40 repeat [General function prediction only]

cd00200
Location:14 → 296

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:46 → 82

7WD40; WD40 repeat [structural motif]
NM_001352057.2 → NP_001338986.1 target of rapamycin complex subunit LST8 isoform c

Status: VALIDATED

Source sequence(s)

AC009065

UniProtKB/TrEMBL

H3BSZ4

Related

ENSP00000456944.1, ENST00000562352.5

Conserved Domains (2) summary

cd00200
Location:14 → 303

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:47 → 89

7WD40; WD40 repeat [structural motif]
NM_001352059.2 → NP_001338988.1 target of rapamycin complex subunit LST8 isoform d

Status: VALIDATED

Source sequence(s)

AC009065

Conserved Domains (2) summary

sd00039
Location:23 → 61

7WD40; WD40 repeat [structural motif]

cl29593
Location:5 → 231

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001352060.2 → NP_001338989.1 target of rapamycin complex subunit LST8 isoform d

Status: VALIDATED

Source sequence(s)

AC009065, AY223837

Related

ENST00000568542.5

Conserved Domains (2) summary

sd00039
Location:23 → 61

7WD40; WD40 repeat [structural motif]

cl29593
Location:5 → 231

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_022372.6 → NP_071767.3 target of rapamycin complex subunit LST8 isoform a

See identical proteins and their annotated locations for NP_071767.3

Status: VALIDATED

Source sequence(s)

AC009065, BC001313

Consensus CDS

CCDS10462.2

UniProtKB/Swiss-Prot

B3KMM4, B4DY00, D3DU88, Q5M800, Q86Y18, Q8WUI5, Q9BVC4, Q9HA66, Q9UJV6

UniProtKB/TrEMBL

H3BSZ4

Related

ENSP00000456405.1, ENST00000569417.6

Conserved Domains (2) summary

cd00200
Location:14 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:47 → 83

7WD40; WD40 repeat [structural motif]

RNA

NR_147904.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC009065
NR_147905.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC009065
NR_147906.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC009065

Related

ENST00000301724.14
NR_147907.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC009065, AK022227

Related

ENST00000566835.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

2205454..2209453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005255475.4 → XP_005255532.3 target of rapamycin complex subunit LST8 isoform X1
XM_047434466.1 → XP_047290422.1 target of rapamycin complex subunit LST8 isoform X2
XM_005255479.3 → XP_005255536.1 target of rapamycin complex subunit LST8 isoform X3

See identical proteins and their annotated locations for XP_005255536.1

UniProtKB/TrEMBL

H3BSZ4

Conserved Domains (2) summary

cd00200
Location:14 → 303

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:47 → 89

7WD40; WD40 repeat [structural motif]
XM_047434467.1 → XP_047290423.1 target of rapamycin complex subunit LST8 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

2227913..2231910

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054313644.1 → XP_054169619.1 target of rapamycin complex subunit LST8 isoform X3
XM_054313641.1 → XP_054169616.1 target of rapamycin complex subunit LST8 isoform X5
XM_054313642.1 → XP_054169617.1 target of rapamycin complex subunit LST8 isoform X6
XM_054313643.1 → XP_054169618.1 target of rapamycin complex subunit LST8 isoform X3
XM_054313645.1 → XP_054169620.1 target of rapamycin complex subunit LST8 isoform X7
XM_054313646.1 → XP_054169621.1 target of rapamycin complex subunit LST8 isoform X8

UniProtKB/TrEMBL

H3BPT1