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    ADGRA3 adhesion G protein-coupled receptor A3 [ Homo sapiens (human) ]

    Gene ID: 166647, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ADGRA3provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor A3provided by HGNC
    Primary source
    HGNC:HGNC:13839
    See related
    Ensembl:ENSG00000152990 MIM:612303; AllianceGenome:HGNC:13839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR21; TEM5L; GPR125
    Summary
    This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.5), liver (RPKM 6.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRA3 in Genome Data Viewer
    Location:
    4p15.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (22387376..22516066, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (22369218..22497870, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (22388999..22517689, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124900841 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:22386916-22388115 Neighboring gene MPRA-validated peak5007 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:22524554-22525248 Neighboring gene microRNA 12115 Neighboring gene ribosomal protein S27 pseudogene 13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:22626384-22627086 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:22627087-22627788 Neighboring gene glucosylceramidase beta 3 (gene/pseudogene) Neighboring gene CDC42 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Arrestin-independent constitutive endocytosis of GPR125/ADGRA3. Spiess K, et al. Ann N Y Acad Sci, 2019 Nov. PMID 31659746, Free PMC Article
    2. Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/β-Catenin Signaling Pathway. Wu Y, et al. Med Sci Monit, 2018 Sep 19. PMID 30231258, Free PMC Article
    3. Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors. Sachs C, et al. Andrology, 2014 Jul. PMID 24902969, Free PMC Article
    4. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Yamamoto Y, et al. Oncogene, 2004 May 13. PMID 15021905
    5. Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. Christoforou A, et al. Mol Psychiatry, 2007 Nov. PMID 17457313

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data support that the constitutive internalization of GPR125 contributes to its biological functions by controlling receptor surface expression and accessibility for ligands
      Title: Arrestin-independent constitutive endocytosis of GPR125/ADGRA3.
    2. GPR125 overexpression inhibited the beta-catenin transcriptional activity, and down-regulated the expression levels of the Wnt downstream proteins-Axin2, c-Myc, cylinD1, and lef-1.
      Title: Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/β-Catenin Signaling Pathway.
    3. ID4 and GPR125 are expressed on partially overlapping spermatogonial populations and are more broadly expressed in normal adult human testis. ID4 and GPR125 could be used for identifying previously unrecognized human spermatogonial subpopulations
      Title: Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ADGRA3 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor A3
    Names
    G-protein coupled receptor 125
    probable G-protein coupled receptor 125

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032963.1 RefSeqGene

      Range
      4989..133679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_145290.4 → NP_660333.2  adhesion G protein-coupled receptor A3 precursor

      See identical proteins and their annotated locations for NP_660333.2

      Status: REVIEWED

      Source sequence(s)
      AC093814, AL832257, BC035645
      Consensus CDS
      CCDS33964.1
      UniProtKB/Swiss-Prot
      Q6UXK9, Q86SQ5, Q8IWK6, Q8TC55
      UniProtKB/TrEMBL
      B3KTN7, B4DRA3
      Related
      ENSP00000334952.5, ENST00000334304.10
      Conserved Domains (10) summary
      cd00096
      Location:262 → 337
      Ig; Immunoglobulin domain
      smart00082
      Location:189 → 223
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:249 → 341
      IG_like; Immunoglobulin like
      cd00116
      Location:70 → 182
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:83 → 106
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:704 → 743
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:363 → 416
      HRM; Hormone receptor domain
      pfam12799
      Location:107 → 146
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:85 → 141
      LRR_8; Leucine rich repeat
      cl21561
      Location:796 → 945
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      22387376..22516066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449703.1 → XP_047305659.1  adhesion G protein-coupled receptor A3 isoform X1

      UniProtKB/TrEMBL
      B3KTN7, B4DRA3

    2. XM_047449704.1 → XP_047305660.1  adhesion G protein-coupled receptor A3 isoform X1

      UniProtKB/TrEMBL
      B3KTN7, B4DRA3
      Related
      ENST00000282943.9

    3. XM_011513811.3 → XP_011512113.1  adhesion G protein-coupled receptor A3 isoform X2

      UniProtKB/TrEMBL
      B3KTN7, B4DRA3
      Conserved Domains (5) summary
      cd00096
      Location:36 → 111
      Ig; Immunoglobulin domain
      smart00410
      Location:23 → 115
      IG_like; Immunoglobulin like
      pfam01825
      Location:478 → 517
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:137 → 190
      HRM; Hormone receptor domain
      cl21561
      Location:570 → 719
      7tm_4; Olfactory receptor

    4. XM_005248137.6 → XP_005248194.1  adhesion G protein-coupled receptor A3 isoform X3

      Conserved Domains (9) summary
      cd00096
      Location:262 → 337
      Ig; Immunoglobulin domain
      smart00082
      Location:189 → 223
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:249 → 341
      IG_like; Immunoglobulin like
      cd00116
      Location:84 → 166
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:83 → 106
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:704 → 743
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:363 → 416
      HRM; Hormone receptor domain
      pfam12799
      Location:107 → 146
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:85 → 141
      LRR_8; Leucine rich repeat

    RNA

    1. XR_007096381.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      22369218..22497870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349097.1 → XP_054205072.1  adhesion G protein-coupled receptor A3 isoform X1

      UniProtKB/TrEMBL
      B3KTN7, B4DRA3

    2. XM_054349096.1 → XP_054205071.1  adhesion G protein-coupled receptor A3 isoform X4

      UniProtKB/TrEMBL
      B3KTN7, B4DRA3

    3. XM_054349098.1 → XP_054205073.1  adhesion G protein-coupled receptor A3 isoform X2

      UniProtKB/TrEMBL
      B3KTN7, B4DRA3

    4. XM_054349099.1 → XP_054205074.1  adhesion G protein-coupled receptor A3 isoform X3

    RNA

    1. XR_008486944.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWK6.2 GenPept UniProtKB/Swiss-Prot:Q8IWK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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