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    TAF3 TATA-box binding protein associated factor 3 [ Homo sapiens (human) ]

    Gene ID: 83860, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TAF3provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 3provided by HGNC
    Primary source
    HGNC:HGNC:17303
    See related
    Ensembl:ENSG00000165632 MIM:606576; AllianceGenome:HGNC:17303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAF140; TAFII140; TAFII-140
    Summary
    The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
    Expression
    Ubiquitous expression in testis (RPKM 5.8), ovary (RPKM 3.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TAF3 in Genome Data Viewer
    Location:
    10p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (7818505..8016631)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (7819254..8017393)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7860468..8058594)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr10:7809082-7809283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2981 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7830681-7831224 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC105376392 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7860144-7860662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7860663-7861180 Neighboring gene Sharpr-MPRA regulatory region 6244 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:8003953-8004117 Neighboring gene Sharpr-MPRA regulatory region 13617 Neighboring gene uncharacterized LOC105376394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:8084925-8085676 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:8085677-8086428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:8086674-8087217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:8087218-8087760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2983 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:8091667-8092510 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:8092511-8093354 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:8093355-8094198 Neighboring gene GATA3 antisense RNA 1 Neighboring gene GATA binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Lauberth SM, et al. Cell, 2013 Feb 28. PMID 23452851, Free PMC Article
    2. Control of embryonic stem cell lineage commitment by core promoter factor, TAF3. Liu Z, et al. Cell, 2011 Sep 2. PMID 21884934, Free PMC Article
    3. Switching of the core transcription machinery during myogenesis. Deato MD, et al. Genes Dev, 2007 Sep 1. PMID 17704303, Free PMC Article
    4. Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans. Pistis G, et al. PLoS One, 2013. PMID 23935956, Free PMC Article
    5. TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. Bereczki O, et al. BMC Mol Biol, 2008 Jun 12. PMID 18549481, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that transcription cofactor TAF3 is required for transcription of the alpha spectrin SPTA1 gene.
      Title: Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.
    2. Study shows that H3K4me3-TAF3 interactions direct global TFIID recruitment to active genes, some of which are p53 targets. Further analyses show that H3K4me3 enhances p53-dependent transcription by stimulating preinitiation complex formation.
      Title: H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation.
    3. Study shows that this TAF3 activity is critical for early lineage segregation during stem cell differentiation.
      Title: Control of embryonic stem cell lineage commitment by core promoter factor, TAF3.
    4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Novel association strategy with copy number variation for identifying new risk Loci of human diseases.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    6. Data identified TAF3 as an evolutionarily conserved negative regulator of p53 transcription activation function.
      Title: TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
    tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
    tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
    tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
    tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25063

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription regulator inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in RNA polymerase II preinitiation complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of protein location in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 3
    Names
    140 kDa TATA box-binding protein-associated factor
    RNA polymerase II transcription factor TAFII140
    TAF(II)140
    TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
    TBP-associated factor 3
    transcription initiation factor TFIID 140 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031923.4 → NP_114129.1  transcription initiation factor TFIID subunit 3

      See identical proteins and their annotated locations for NP_114129.1

      Status: VALIDATED

      Source sequence(s)
      AL159172, AL353754, AL390294
      Consensus CDS
      CCDS41487.1
      UniProtKB/Swiss-Prot
      Q05DA0, Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8
      Related
      ENSP00000340271.5, ENST00000344293.6
      Conserved Domains (4) summary
      smart00576
      Location:5 → 79
      BTP; Bromodomain transcription factors and PHD domain containing proteins
      PTZ00449
      Location:229 → 388
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PRK12323
      Location:777 → 847
      PRK12323; DNA polymerase III subunit gamma/tau
      cd15522
      Location:867 → 912
      PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      7818505..8016631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519741.2 → XP_011518043.2  transcription initiation factor TFIID subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KR98
      Related
      ENSP00000508875.1, ENST00000687522.1
      Conserved Domains (4) summary
      smart00576
      Location:5 → 79
      BTP; Bromodomain transcription factors and PHD domain containing proteins
      cd15522
      Location:866 → 911
      PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
      cl25751
      Location:228 → 387
      DUF4045; Domain of unknown function (DUF4045)
      cl26386
      Location:776 → 846
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      7819254..8017393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366902.1 → XP_054222877.1  transcription initiation factor TFIID subunit 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VWG9.1 GenPept UniProtKB/Swiss-Prot:Q5VWG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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