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    SHB SH2 domain containing adaptor protein B [ Homo sapiens (human) ]

    Gene ID: 6461, updated on 9-Dec-2024

    Summary

    Official Symbol
    SHBprovided by HGNC
    Official Full Name
    SH2 domain containing adaptor protein Bprovided by HGNC
    Primary source
    HGNC:HGNC:10838
    See related
    Ensembl:ENSG00000107338 MIM:600314; AllianceGenome:HGNC:10838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    bA3J10.2
    Summary
    Enables phosphotyrosine residue binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 4.9), kidney (RPKM 3.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SHB in Genome Data Viewer
    Location:
    9p13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37915898..38069227, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37939809..38093156, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37915895..38069224, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 10 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5 Neighboring gene solute carrier family 25 member 51 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19914 Neighboring gene thioredoxin related transmembrane protein 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37923197-37923808 Neighboring gene RNA, U7 small nuclear 124 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:37951849-37952348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:37997675-37998176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28408 Neighboring gene Sharpr-MPRA regulatory region 5136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38008584-38009525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38010092-38010724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19915 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38016883-38017646 Neighboring gene Sharpr-MPRA regulatory region 2787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38021463-38021972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38026045-38026553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38026554-38027063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38027064-38027572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38027573-38028081 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:38028793-38028962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:38030139-38030638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:38032069-38032570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38037811-38038416 Neighboring gene VISTA enhancer hs2062 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:38047203-38048402 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:38048927-38049920 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:38058891-38060090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:38067661-38068464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19917 Neighboring gene uncharacterized LOC105376039 Neighboring gene Sharpr-MPRA regulatory region 13386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28411 Neighboring gene U8 small nucleolar RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    Voxelwise genome-wide association study (vGWAS).
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38908

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor complex adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hematopoietic stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T-helper cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SH2 domain-containing adapter protein B
    Names
    SHB (Src homology 2 domain containing) adaptor protein B
    SHB adaptor protein (a Src homology 2 protein)
    Src homology 2 domain containing adaptor protein B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003028.3NP_003019.2  SH2 domain-containing adapter protein B

      See identical proteins and their annotated locations for NP_003019.2

      Status: VALIDATED

      Source sequence(s)
      AL138752, AL161448, AL583849
      Consensus CDS
      CCDS43806.1
      UniProtKB/Swiss-Prot
      B9EGM0, D3DRQ5, Q15464, Q504U5, Q5VUM8
      Related
      ENSP00000366936.3, ENST00000377707.4
      Conserved Domains (1) summary
      cd10389
      Location:408504
      SH2_SHB; Src homology 2 domain found in SH2 domain-containing adapter protein B (SHB)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      37915898..38069227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      37939809..38093156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)