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    BNIP5 BCL2 interacting protein 5 [ Homo sapiens (human) ]

    Gene ID: 389384, updated on 27-Nov-2024

    Summary

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    Official Symbol
    BNIP5provided by HGNC
    Official Full Name
    BCL2 interacting protein 5provided by HGNC
    Primary source
    HGNC:HGNC:33769
    See related
    Ensembl:ENSG00000189325 AllianceGenome:HGNC:33769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C6orf222
    Expression
    Biased expression in small intestine (RPKM 9.9), duodenum (RPKM 9.6) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BNIP5 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36315761..36336888, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36136083..36157178, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36283538..36304665, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene BRPF3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24421 Neighboring gene bromodomain and PHD finger containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36203227-36203772 Neighboring gene Sharpr-MPRA regulatory region 10771 Neighboring gene uncharacterized LOC105375036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17111 Neighboring gene patatin like phospholipase domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36235945-36236531 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:36253718-36253903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36269917-36270417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36343773-36344272 Neighboring gene ETS variant transcription factor 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36354517-36355340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17114 Neighboring gene ETV7 and PTX1 antisense RNA 1 Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24427 Neighboring gene PXT1 intron CAGE-defined low expression enhancer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins. DeBartolo J, et al. PLoS Comput Biol, 2014 Jun. PMID 24967846, Free PMC Article
    2. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
    3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • DKFZp779B1540

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein BNIP5
    Names
    uncharacterized protein C6orf222

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052656.1 RefSeqGene

      Range
      5128..26255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001010903.5 → NP_001010903.3  protein BNIP5

      See identical proteins and their annotated locations for NP_001010903.3

      Status: VALIDATED

      Source sequence(s)
      BC140873, BX648558, Z84484
      Consensus CDS
      CCDS34439.1
      UniProtKB/Swiss-Prot
      B2RTY8, P0C671
      Related
      ENSP00000418983.1, ENST00000437635.3
      Conserved Domains (1) summary
      pfam15661
      Location:14 → 652
      CF222; C6orf222, uncharacterized family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      36315761..36336888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514598.3 → XP_011512900.1  protein BNIP5 isoform X3

      Conserved Domains (1) summary
      pfam15661
      Location:1 → 404
      CF222; C6orf222, uncharacterized family

    2. XM_011514597.3 → XP_011512899.1  protein BNIP5 isoform X2

      Conserved Domains (1) summary
      pfam15661
      Location:14 → 651
      CF222; C6orf222, uncharacterized family

    3. XM_011514596.3 → XP_011512898.1  protein BNIP5 isoform X1

      See identical proteins and their annotated locations for XP_011512898.1

      UniProtKB/Swiss-Prot
      B2RTY8, P0C671
      Conserved Domains (1) summary
      pfam15661
      Location:14 → 652
      CF222; C6orf222, uncharacterized family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      36136083..36157178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355415.1 → XP_054211390.1  protein BNIP5 isoform X3

    2. XM_054355414.1 → XP_054211389.1  protein BNIP5 isoform X2

    3. XM_054355413.1 → XP_054211388.1  protein BNIP5 isoform X1

      UniProtKB/Swiss-Prot
      B2RTY8, P0C671
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C671.1 GenPept UniProtKB/Swiss-Prot:P0C671

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