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    NALF2 NALCN channel auxiliary factor 2 [ Homo sapiens (human) ]

    Gene ID: 27112, updated on 9-Dec-2024

    Summary

    Official Symbol
    NALF2provided by HGNC
    Official Full Name
    NALCN channel auxiliary factor 2provided by HGNC
    Primary source
    HGNC:HGNC:30701
    See related
    Ensembl:ENSG00000130054 AllianceGenome:HGNC:30701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TED; TMEM28; CXorf63; FAM155B; bB57D9.1
    Summary
    This gene encodes a product belonging to a family of proteins with unknown function. The presence of two transmembrane domains suggests that this protein is a multi-pass membrane protein. [provided by RefSeq, Sep 2011]
    Expression
    Biased expression in thyroid (RPKM 3.9), heart (RPKM 3.6) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NALF2 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (69504326..69532508)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (67937741..67965930)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (68724169..68752351)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68409565-68410066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68410067-68410566 Neighboring gene long intergenic non-protein coding RNA 269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68437057-68437556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68442199-68442970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68475969-68476469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68476955-68477456 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:68482961-68483512 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:68483513-68484063 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:68484064-68484614 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:68500351-68500533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68505841-68506822 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chrX:68509810-68510701 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68513811-68514311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68513310-68513810 Neighboring gene NANOG hESC enhancer GRCh37_chrX:68525339-68525849 Neighboring gene NANOG hESC enhancer GRCh37_chrX:68597698-68598220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68668613-68669113 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:68725122-68725295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:68726227-68726726 Neighboring gene CYCS pseudogene 43 Neighboring gene MPRA-validated peak7391 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20888 Neighboring gene uncharacterized LOC124905293 Neighboring gene RNA, 5S ribosomal pseudogene 506 Neighboring gene ectodysplasin A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to stretch-activated, monoatomic cation-selective, calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NALCN channel auxiliary factor 2
    Names
    bB57D9.1 (TED protein)
    family with sequence similarity 155 member B
    transmembrane protein 28
    transmembrane protein FAM155B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021282.1 RefSeqGene

      Range
      4092..32274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015686.3NP_056501.2  NALCN channel auxiliary factor 2

      See identical proteins and their annotated locations for NP_056501.2

      Status: VALIDATED

      Source sequence(s)
      AL158069
      Consensus CDS
      CCDS35317.1
      UniProtKB/Swiss-Prot
      B1ALV6, B9EGK1, D3DVU1, O75949
      Related
      ENSP00000252338.5, ENST00000252338.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      69504326..69532508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530909.3XP_011529211.1  NALCN channel auxiliary factor 2 isoform X2

    2. XM_011530908.3XP_011529210.1  NALCN channel auxiliary factor 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      67937741..67965930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326832.1XP_054182807.1  NALCN channel auxiliary factor 2 isoform X2

    2. XM_054326831.1XP_054182806.1  NALCN channel auxiliary factor 2 isoform X1