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    STK16 serine/threonine kinase 16 [ Homo sapiens (human) ]

    Gene ID: 8576, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STK16provided by HGNC
    Official Full Name
    serine/threonine kinase 16provided by HGNC
    Primary source
    HGNC:HGNC:11394
    See related
    Ensembl:ENSG00000115661 MIM:604719; AllianceGenome:HGNC:11394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSK; KRCT; MPSK; TSF1; hPSK; PKL12
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.6), brain (RPKM 6.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK16 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219245479..219250337)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219730246..219735104)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220110201..220115059)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220093298-220093846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220093847-220094394 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220094395-220094942 Neighboring gene ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 Neighboring gene galactosidase beta 1 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220109882-220110464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17148 Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220142208-220142912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12352 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220150891-220151858

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. STK16 regulates actin dynamics to control Golgi organization and cell cycle. Liu J, et al. Sci Rep, 2017 Mar 15. PMID 28294156, Free PMC Article
    2. STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner. Peng L, et al. Mol Med, 2024 Apr 15. PMID 38622518, Free PMC Article
    3. Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. Berson AE, et al. Biochem Biophys Res Commun, 1999 Jun 16. PMID 10364453
    4. Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells. In JG, et al. Biochem J, 2014 Oct 15. PMID 25084525, Free PMC Article
    5. Exosomes from M1-polarized macrophages promote apoptosis in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis. Wang X, et al. Cancer Sci, 2022 Mar. PMID 35092121, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serine/Threonine kinase 16 phosphorylates STAT3 and confers a JAK2-Inhibition resistance phenotype in triple-negative breast cancer.
      Title: Serine/Threonine kinase 16 phosphorylates STAT3 and confers a JAK2-Inhibition resistance phenotype in triple-negative breast cancer.
    2. STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner.
      Title: STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner.
    3. Exosomes from M1-polarized macrophages promote apoptosis in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis.
      Title: Exosomes from M1-polarized macrophages promote apoptosis in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis.
    4. we revealed STK16 as a novel actin binding protein that resides in the Golgi, which regulates actin dynamics to control Golgi structure and participate in cell cycle progression.
      Title: STK16 regulates actin dynamics to control Golgi organization and cell cycle.
    5. MAL2 and STK16 function to sort secretory soluble cargo into the constitutive secretory pathway in hepatocytes.
      Title: Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.
    6. The Endogenous STK16 subcellular localization was evaluated by indirect immunofluorescence in NRK cells, demonstrating a Golgi-associated pattern that appears to be independent of signals provided by integrin pathways.
      Title: Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39635, MGC16211

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi-associated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 16
    Names
    TGF-beta-stimulated factor 1
    myristoylated and palmitoylated serine/threonine-protein kinase
    protein kinase PKL12
    protein kinase expressed in day 12 fetal liver
    tyrosine-protein kinase STK16
    NP_001008910.1
    NP_001317142.1
    NP_001317143.1
    NP_001317144.1
    XP_024308963.1
    XP_047302096.1
    XP_047302097.1
    XP_054200279.1
    XP_054200280.1
    XP_054200281.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008910.4 → NP_001008910.1  serine/threonine-protein kinase 16 isoform 1

      See identical proteins and their annotated locations for NP_001008910.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AC068946
      Consensus CDS
      CCDS42822.1
      UniProtKB/Swiss-Prot
      A8K9H9, O75716, Q5U0F8, Q96KI2, Q9BUH4, Q9UEN3, Q9UP78
      UniProtKB/TrEMBL
      B8ZZN3
      Related
      ENSP00000386928.3, ENST00000409638.7
      Conserved Domains (1) summary
      cd13986
      Location:19 → 295
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    2. NM_001330213.2 → NP_001317142.1  serine/threonine-protein kinase 16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC068946
      Consensus CDS
      CCDS42822.1
      UniProtKB/Swiss-Prot
      A8K9H9, O75716, Q5U0F8, Q96KI2, Q9BUH4, Q9UEN3, Q9UP78
      UniProtKB/TrEMBL
      B8ZZN3
      Related
      ENSP00000379964.2, ENST00000396738.7
      Conserved Domains (1) summary
      cd13986
      Location:19 → 295
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    3. NM_001330214.1 → NP_001317143.1  serine/threonine-protein kinase 16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC068946, AK298471
      Consensus CDS
      CCDS82573.1
      UniProtKB/TrEMBL
      B8ZZI5
      Related
      ENSP00000386553.1, ENST00000409743.1
      Conserved Domains (1) summary
      cd13986
      Location:19 → 263
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    4. NM_001330215.2 → NP_001317144.1  serine/threonine-protein kinase 16 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC068946
      Consensus CDS
      CCDS86921.1
      UniProtKB/TrEMBL
      B4DPS1
      Related
      ENSP00000386309.3, ENST00000409516.7
      Conserved Domains (1) summary
      cl21453
      Location:29 → 177
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      219245479..219250337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446140.1 → XP_047302096.1  serine/threonine-protein kinase 16 isoform X1

      UniProtKB/TrEMBL
      B8ZZI5

    2. XM_024453195.2 → XP_024308963.1  serine/threonine-protein kinase 16 isoform X1

      UniProtKB/TrEMBL
      B8ZZI5
      Conserved Domains (1) summary
      cd13986
      Location:19 → 263
      STKc_16; Catalytic domain of Serine/Threonine Kinase 16

    3. XM_047446141.1 → XP_047302097.1  serine/threonine-protein kinase 16 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      219730246..219735104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344304.1 → XP_054200279.1  serine/threonine-protein kinase 16 isoform X1

      UniProtKB/TrEMBL
      B8ZZI5

    2. XM_054344305.1 → XP_054200280.1  serine/threonine-protein kinase 16 isoform X1

      UniProtKB/TrEMBL
      B8ZZI5

    3. XM_054344306.1 → XP_054200281.1  serine/threonine-protein kinase 16 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_003691.2: Suppressed sequence

      Description
      NM_003691.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_032768.1: Suppressed sequence

      Description
      NM_032768.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75716.4 GenPept UniProtKB/Swiss-Prot:O75716

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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