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    PLA2G3 phospholipase A2 group III [ Homo sapiens (human) ]

    Gene ID: 50487, updated on 9-Dec-2024

    Summary

    Official Symbol
    PLA2G3provided by HGNC
    Official Full Name
    phospholipase A2 group IIIprovided by HGNC
    Primary source
    HGNC:HGNC:17934
    See related
    Ensembl:ENSG00000100078 MIM:611651; AllianceGenome:HGNC:17934
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPLA2III; sPLA2-III; GIII-SPLA2
    Summary
    This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
    Expression
    Biased expression in skin (RPKM 3.5), esophagus (RPKM 1.9) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PLA2G3 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (31134807..31140508, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31598311..31604012, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31530793..31536494, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372995 Neighboring gene ribosomal protein S15a pseudogene 37 Neighboring gene inositol polyphosphate-5-phosphatase J Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31533780-31534280 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31535998-31536556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31536557-31537116 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:31543860-31544038 Neighboring gene Sharpr-MPRA regulatory region 9733 Neighboring gene SNRPN pseudogene 2 Neighboring gene microRNA 3928

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
    env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acrosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipoxygenase pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of amyloid-beta clearance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylcholine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylglycerol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylserine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of histamine secretion by mast cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage derived foam cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mast cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of prostaglandin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in production of molecular mediator involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sperm axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    group 3 secretory phospholipase A2
    Names
    group III secreted phospholipase A2
    phosphatidylcholine 2-acylhydrolase 3
    phosphatidylcholine 2-acylhydrolase GIII
    NP_056530.2
    XP_011528506.1
    XP_011528507.1
    XP_054181637.1
    XP_054181638.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015715.5NP_056530.2  group 3 secretory phospholipase A2 precursor

      See identical proteins and their annotated locations for NP_056530.2

      Status: REVIEWED

      Source sequence(s)
      AC005005, AF220490, BC025316
      Consensus CDS
      CCDS13889.1
      UniProtKB/Swiss-Prot
      O95768, Q9NZ20
      Related
      ENSP00000215885.3, ENST00000215885.4
      Conserved Domains (2) summary
      cd04704
      Location:151247
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...
      cd04705
      Location:314427
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      31134807..31140508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530205.2XP_011528507.1  group 3 secretory phospholipase A2 isoform X1

      See identical proteins and their annotated locations for XP_011528507.1

      Conserved Domains (2) summary
      cd04705
      Location:133246
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...
      cl05417
      Location:3566
      PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
    2. XM_011530204.2XP_011528506.1  group 3 secretory phospholipase A2 isoform X1

      See identical proteins and their annotated locations for XP_011528506.1

      Conserved Domains (2) summary
      cd04705
      Location:133246
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...
      cl05417
      Location:3566
      PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      31598311..31604012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325663.1XP_054181638.1  group 3 secretory phospholipase A2 isoform X1

    2. XM_054325662.1XP_054181637.1  group 3 secretory phospholipase A2 isoform X1