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    SCGB2B2 secretoglobin family 2B member 2 [ Homo sapiens (human) ]

    Gene ID: 284402, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SCGB2B2provided by HGNC
    Official Full Name
    secretoglobin family 2B member 2provided by HGNC
    Primary source
    HGNC:HGNC:27616
    See related
    Ensembl:ENSG00000205209 MIM:615063; AllianceGenome:HGNC:27616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCGBL; SCGB4A2
    Summary
    Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See SCGB2B2 in Genome Data Viewer
    Location:
    19q13.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (34585529..34677159, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37130104..37221748, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35076434..35168064, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 55 Neighboring gene zinc finger protein 807, pseudogene Neighboring gene uncharacterized LOC105372374 Neighboring gene secretoglobin family 1B member 2, pseudogene Neighboring gene zinc finger protein 530-like Neighboring gene secretoglobin family 2B member 3, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35154774-35155274 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35167555-35168452 Neighboring gene secretoglobin family 1B member 3, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35168453-35169349 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35170207-35170708 Neighboring gene zinc finger protein 302 Neighboring gene secretoglobin family 2B member 1, pseudogene Neighboring gene secretoglobin family 1B member 1, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. Jackson BC, et al. Hum Genomics, 2011 Oct. PMID 22155607, Free PMC Article
    2. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
    3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secretoglobin family 2B member 2
    Names
    secretoglobin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025591.4 → NP_001020762.1  secretoglobin family 2B member 2 precursor

      See identical proteins and their annotated locations for NP_001020762.1

      Status: VALIDATED

      Source sequence(s)
      AC020910, AC022143, AK093495
      Consensus CDS
      CCDS32989.1
      UniProtKB/Swiss-Prot
      Q4G0G5
      Related
      ENSP00000469876.1, ENST00000601241.6
      Conserved Domains (1) summary
      pfam01099
      Location:30 → 91
      Uteroglobin; Uteroglobin family

    RNA

    1. NR_170946.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020910, AC022143

    2. NR_170947.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020910, AC022143

    3. NR_170948.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020910, AC022143

    4. NR_170949.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020910, AC022143

    5. NR_170950.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020910, AC022143

    6. NR_170951.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020910, AC022143

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      34585529..34677159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      37130104..37221748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G0G5.1 GenPept UniProtKB/Swiss-Prot:Q4G0G5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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