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    SH3KBP1 SH3 domain containing kinase binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 30011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SH3KBP1provided by HGNC
    Official Full Name
    SH3 domain containing kinase binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:13867
    See related
    Ensembl:ENSG00000147010 MIM:300374; AllianceGenome:HGNC:13867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSB1; AGMX2; CIN85; GIG10; HSB-1; IMD61; MIG18; CD2BP3
    Summary
    This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in lymph node (RPKM 19.2), fat (RPKM 15.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SH3KBP1 in Genome Data Viewer
    Location:
    Xp22.12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (19533977..19887600, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (19116856..19470507, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (19552095..19905718, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:19391289-19392229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29463 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene pyruvate dehydrogenase E1 subunit alpha 1 Neighboring gene eukaryotic translation initiation factor 5 pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:19643274-19644473 Neighboring gene uncharacterized LOC124905255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:19740595-19741095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:19820680-19821600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29470 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:19880674-19881280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29476 Neighboring gene uncharacterized LOC124905256 Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:20001035-20001226 Neighboring gene uncharacterized LOC729609

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex. Havrylov S, et al. Traffic, 2008 May. PMID 18266907
    2. Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma MCF-7 cells. Vynnytska-Myronovska BO, et al. Ukr Biochem J, 2014 Sep-Oct. PMID 25816594
    3. Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85. Philippe D, et al. Biochemistry, 2011 May 10. PMID 21446695
    4. Adaptor protein Ruk1 forms protein-protein complexes with endonuclease activity in HEK293 cells. Kit YY, et al. Biochemistry (Mosc), 2003 Jul. PMID 12946264
    5. The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation. Kühn J, et al. Sci Signal, 2016 Jun 28. PMID 27353366

    See all (164) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.
      Title: E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.
    2. High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma.
      Title: High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma.
    3. In Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain.
      Title: In Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain.
    4. The three N-terminal SH3 domains of CIN85 bind to the N-terminus of PHD2.
      Title: The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.
    5. These results reveal nonredundant functions of CIN85 for humoral immune responses.
      Title: Germline deletion of CIN85 in humans with X chromosome-linked antibody deficiency.
    6. These studies demonstrate a requirement for human herpesvirus 5 pUL135 interactions with Abi-1 and CIN85 for regulation of EGFR and mechanistically link the regulation of EGFR to virus reactivation.
      Title: Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.
    7. Transcriptional regulation of NOX genes expression in human breast adenocarcinoma cells is modulated by adaptor protein CIN85.
      Title: Transcriptional regulation of NOX genes express ion in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN 85.
    8. The multiple Src homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP-65 molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process.
      Title: The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation.
    9. these data support a role for the novel PP2Ac-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
      Title: A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in αIIbβ3 Integrin Signaling.
    10. CIN85 promotes recycling of TGF-beta receptors and thereby positively regulates TGF-beta signaling.
      Title: CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Immunodeficiency 61
    MedGen: C1845903 OMIM: 300310 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Genome-wide shRNA screening identifies SH3KBP1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing kinase-binding protein 1
    Names
    CD2-binding protein 3
    SH3-domain kinase binding protein 1
    Src family kinase-binding protein 1
    c-Cbl-interacting protein
    cbl-interacting protein of 85 kDa
    human Src family kinase-binding protein 1
    migration-inducing gene 18
    src-related kinase binding protein-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021367.1 RefSeqGene

      Range
      5027..358650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024666.3 → NP_001019837.1  SH3 domain-containing kinase-binding protein 1 isoform b

      See identical proteins and their annotated locations for NP_001019837.1

      Status: REVIEWED

      Source sequence(s)
      AF542051, AL732423, DC409010
      Consensus CDS
      CCDS35213.1
      UniProtKB/TrEMBL
      A0A8V8TQD8
      Related
      ENSP00000514545.1, ENST00000699723.1
      Conserved Domains (2) summary
      cd12055
      Location:65 → 117
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:234 → 289
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    2. NM_001184960.2 → NP_001171889.1  SH3 domain-containing kinase-binding protein 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AK293237, AL732327, AL732423, BP224209
      Consensus CDS
      CCDS55383.1
      UniProtKB/Swiss-Prot
      Q96B97
      Related
      ENSP00000369039.1, ENST00000379716.5
      Conserved Domains (1) summary
      cd12057
      Location:33 → 88
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    3. NM_001353890.2 → NP_001340819.1  SH3 domain-containing kinase-binding protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423, AL772197
      Consensus CDS
      CCDS94571.1
      UniProtKB/TrEMBL
      A0A8V8TP33, A0A8V8TQD8
      Related
      ENSP00000514516.1, ENST00000699673.1
      Conserved Domains (3) summary
      cd12052
      Location:3 → 55
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102 → 154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:271 → 326
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    4. NM_001353891.2 → NP_001340820.1  SH3 domain-containing kinase-binding protein 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423, AL772197
      Consensus CDS
      CCDS94573.1
      UniProtKB/TrEMBL
      A0A8V8TP27, A0A8V8TQD8
      Related
      ENSP00000514511.1, ENST00000699668.1
      Conserved Domains (3) summary
      cd12052
      Location:3 → 55
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102 → 154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:296 → 351
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    5. NM_001353892.2 → NP_001340821.1  SH3 domain-containing kinase-binding protein 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423, AL772197
      Consensus CDS
      CCDS94572.1
      UniProtKB/TrEMBL
      A0A8V8TNT5, A0A8V8TQD8
      Related
      ENSP00000514514.1, ENST00000699671.1
      Conserved Domains (3) summary
      cd12052
      Location:3 → 55
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102 → 154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:296 → 351
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    6. NM_001353893.2 → NP_001340822.1  SH3 domain-containing kinase-binding protein 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423
      Consensus CDS
      CCDS94568.1
      UniProtKB/TrEMBL
      A0A8V8TQG3, A0A8V8TQU1
      Related
      ENSP00000514711.1, ENST00000699726.1
      Conserved Domains (2) summary
      cd12055
      Location:43 → 95
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:237 → 292
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    7. NM_001353894.2 → NP_001340823.1  SH3 domain-containing kinase-binding protein 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423
      Consensus CDS
      CCDS94567.1
      UniProtKB/TrEMBL
      A0A8V8TP40, A0A8V8TQG3
      Related
      ENSP00000514713.1, ENST00000699733.1
      Conserved Domains (2) summary
      cd12055
      Location:43 → 95
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:237 → 292
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    8. NM_001353895.2 → NP_001340824.1  SH3 domain-containing kinase-binding protein 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423
      Consensus CDS
      CCDS94569.1
      UniProtKB/TrEMBL
      A0A8V8TPM1, A0A8V8TQG3
      Related
      ENSP00000514710.1, ENST00000699720.1
      Conserved Domains (2) summary
      cd12055
      Location:43 → 95
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:256 → 311
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    9. NM_001353897.2 → NP_001340826.1  SH3 domain-containing kinase-binding protein 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL732327, AL732423
      Consensus CDS
      CCDS94565.1
      UniProtKB/TrEMBL
      A0A8V8TP69
      Related
      ENSP00000514555.1, ENST00000699738.1
      Conserved Domains (2) summary
      cd12057
      Location:33 → 88
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
      cl25508
      Location:325 → 384
      Spc7; Spc7 kinetochore protein

    10. NM_001410756.1 → NP_001397685.1  SH3 domain-containing kinase-binding protein 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423, AL772197
      Consensus CDS
      CCDS94575.1
      UniProtKB/TrEMBL
      A0A8V8TQD8, Q5JPT2
      Related
      ENSP00000369049.4, ENST00000379726.8

    11. NM_001410757.1 → NP_001397686.1  SH3 domain-containing kinase-binding protein 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423, AL772197
      Consensus CDS
      CCDS94574.1
      UniProtKB/TrEMBL
      A0A8V8TNL0, A0A8V8TQD8
      Related
      ENSP00000514513.1, ENST00000699670.1

    12. NM_001410758.1 → NP_001397687.1  SH3 domain-containing kinase-binding protein 1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL732325, AL732327, AL732423
      Consensus CDS
      CCDS94566.1
      UniProtKB/TrEMBL
      A0A8V8TP63, A0A8V8TQG3
      Related
      ENSP00000514549.1, ENST00000699729.1

    13. NM_031892.3 → NP_114098.1  SH3 domain-containing kinase-binding protein 1 isoform a

      See identical proteins and their annotated locations for NP_114098.1

      Status: REVIEWED

      Source sequence(s)
      AF230904, AL732423
      Consensus CDS
      CCDS14193.1
      UniProtKB/Swiss-Prot
      B7Z1D5, Q5JPT4, Q5JPT5, Q8IWX6, Q8IX98, Q96B97, Q96RN4, Q9NYR0
      UniProtKB/TrEMBL
      A0A8V8TQD8, Q5JPT6
      Related
      ENSP00000380921.3, ENST00000397821.8
      Conserved Domains (3) summary
      cd12052
      Location:3 → 55
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102 → 154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:271 → 326
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      19533977..19887600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029468.3 → XP_016884957.1  SH3 domain-containing kinase-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8V8TQG3

    2. XM_047442043.1 → XP_047297999.1  SH3 domain-containing kinase-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQD8

    3. XM_017029467.3 → XP_016884956.1  SH3 domain-containing kinase-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TQG3

    4. XM_017029461.2 → XP_016884950.1  SH3 domain-containing kinase-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQD8

    5. XM_017029460.2 → XP_016884949.1  SH3 domain-containing kinase-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TQD8

    6. XM_047442044.1 → XP_047298000.1  SH3 domain-containing kinase-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQG3
      Related
      ENST00000699722.1

    7. XM_047442040.1 → XP_047297996.1  SH3 domain-containing kinase-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TNW8, A0A8V8TQG3
      Related
      ENSP00000514547.1, ENST00000699725.1

    8. XM_047442047.1 → XP_047298003.1  SH3 domain-containing kinase-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8V8TQG3

    9. XM_011545499.4 → XP_011543801.1  SH3 domain-containing kinase-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TQD8
      Conserved Domains (2) summary
      cd12055
      Location:65 → 117
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:278 → 333
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    10. XM_047442048.1 → XP_047298004.1  SH3 domain-containing kinase-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8V8TP63, A0A8V8TQG3

    11. XM_047442045.1 → XP_047298001.1  SH3 domain-containing kinase-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQG3

    12. XM_047442041.1 → XP_047297997.1  SH3 domain-containing kinase-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TNW8, A0A8V8TQG3

    13. XM_047442046.1 → XP_047298002.1  SH3 domain-containing kinase-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8V8TQG3

    14. XM_047442042.1 → XP_047297998.1  SH3 domain-containing kinase-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQD8

    15. XM_047442039.1 → XP_047297995.1  SH3 domain-containing kinase-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TQD8

    16. XM_017029469.2 → XP_016884958.1  SH3 domain-containing kinase-binding protein 1 isoform X16

      UniProtKB/TrEMBL
      B7Z6E8
      Related
      ENST00000699736.1
      Conserved Domains (2) summary
      cd12057
      Location:10 → 65
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
      pfam10267
      Location:339 → 396
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    17. XM_047442050.1 → XP_047298006.1  SH3 domain-containing kinase-binding protein 1 isoform X17

    18. XM_011545502.3 → XP_011543804.1  SH3 domain-containing kinase-binding protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8V8TQF6
      Related
      ENSP00000514544.1, ENST00000699721.1
      Conserved Domains (1) summary
      cd12057
      Location:50 → 105
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    19. XM_011545503.4 → XP_011543805.1  SH3 domain-containing kinase-binding protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8V8TNS8
      Conserved Domains (3) summary
      cd12052
      Location:3 → 55
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102 → 154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:315 → 370
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      19116856..19470507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326929.1 → XP_054182904.1  SH3 domain-containing kinase-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8V8TQG3

    2. XM_054326923.1 → XP_054182898.1  SH3 domain-containing kinase-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TQD8

    3. XM_054326933.1 → XP_054182908.1  SH3 domain-containing kinase-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8V8TQG3

    4. XM_054326927.1 → XP_054182902.1  SH3 domain-containing kinase-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQD8

    5. XM_054326925.1 → XP_054182900.1  SH3 domain-containing kinase-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQD8

    6. XM_054326928.1 → XP_054182903.1  SH3 domain-containing kinase-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQG3

    7. XM_054326924.1 → XP_054182899.1  SH3 domain-containing kinase-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V8TNW8, A0A8V8TQG3

    8. XM_054326932.1 → XP_054182907.1  SH3 domain-containing kinase-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8V8TQG3

    9. XM_054326922.1 → XP_054182897.1  SH3 domain-containing kinase-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TQD8

    10. XM_054326934.1 → XP_054182909.1  SH3 domain-containing kinase-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8V8TP63, A0A8V8TQG3

    11. XM_054326930.1 → XP_054182905.1  SH3 domain-containing kinase-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQG3

    12. XM_054326926.1 → XP_054182901.1  SH3 domain-containing kinase-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQD8

    13. XM_054326931.1 → XP_054182906.1  SH3 domain-containing kinase-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8V8TQG3

    14. XM_054326921.1 → XP_054182896.1  SH3 domain-containing kinase-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TQD8

    15. XM_054326937.1 → XP_054182912.1  SH3 domain-containing kinase-binding protein 1 isoform X16

      UniProtKB/TrEMBL
      B7Z6E8

    16. XM_054326939.1 → XP_054182914.1  SH3 domain-containing kinase-binding protein 1 isoform X17

    17. XM_054326935.1 → XP_054182910.1  SH3 domain-containing kinase-binding protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8V8TQF6

    18. XM_054326938.1 → XP_054182913.1  SH3 domain-containing kinase-binding protein 1 isoform X16

      UniProtKB/TrEMBL
      B7Z6E8

    19. XM_054326936.1 → XP_054182911.1  SH3 domain-containing kinase-binding protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8V8TNS8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96B97.2 GenPept UniProtKB/Swiss-Prot:Q96B97

    Gene LinkOut

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