U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZNF84 zinc finger protein 84 [ Homo sapiens (human) ]

    Gene ID: 7637, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZNF84provided by HGNC
    Official Full Name
    zinc finger protein 84provided by HGNC
    Primary source
    HGNC:HGNC:13159
    See related
    Ensembl:ENSG00000198040 MIM:618554; AllianceGenome:HGNC:13159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPF2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 7.4), endometrium (RPKM 6.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF84 in Genome Data Viewer
    Location:
    12q24.33; map from Rosati ref via FISH [AFS]
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (133037509..133063299)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133094846..133120602)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133614095..133639885)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene zinc finger protein 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5134 Neighboring gene ZNF84 divergent transcript Neighboring gene PTP4A1 pseudogene 2 Neighboring gene MPRA-validated peak2056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7399 Neighboring gene zinc finger protein 140 Neighboring gene zinc finger protein 891 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26217 Neighboring gene ribosomal protein L23a pseudogene 67

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    zinc finger protein 84
    Names
    zinc finger protein HPF2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127372.3NP_001120844.1  zinc finger protein 84

      See identical proteins and their annotated locations for NP_001120844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31940.1
      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Conserved Domains (4) summary
      smart00349
      Location:968
      KRAB; krueppel associated box
      COG5048
      Location:317724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278302
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001289971.2NP_001276900.1  zinc finger protein 84

      See identical proteins and their annotated locations for NP_001276900.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31940.1
      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Related
      ENSP00000445549.1, ENST00000539354.6
      Conserved Domains (4) summary
      smart00349
      Location:968
      KRAB; krueppel associated box
      COG5048
      Location:317724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278302
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001289972.2NP_001276901.1  zinc finger protein 84

      See identical proteins and their annotated locations for NP_001276901.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31940.1
      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Related
      ENSP00000331465.7, ENST00000327668.11
      Conserved Domains (4) summary
      smart00349
      Location:968
      KRAB; krueppel associated box
      COG5048
      Location:317724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278302
      zf-H2C2_2; Zinc-finger double domain
    4. NM_003428.6NP_003419.3  zinc finger protein 84

      See identical proteins and their annotated locations for NP_003419.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31940.1
      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Related
      ENSP00000376133.2, ENST00000392319.6
      Conserved Domains (4) summary
      smart00349
      Location:968
      KRAB; krueppel associated box
      COG5048
      Location:317724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278302
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      133037509..133063299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429505.1XP_047285461.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    2. XM_047429511.1XP_047285467.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    3. XM_047429507.1XP_047285463.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    4. XM_047429504.1XP_047285460.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    5. XM_011534832.2XP_011533134.1  zinc finger protein 84 isoform X1

      See identical proteins and their annotated locations for XP_011533134.1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Conserved Domains (4) summary
      smart00349
      Location:968
      KRAB; krueppel associated box
      COG5048
      Location:317724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278302
      zf-H2C2_2; Zinc-finger double domain
    6. XM_047429506.1XP_047285462.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    7. XM_005266186.2XP_005266243.1  zinc finger protein 84 isoform X1

      See identical proteins and their annotated locations for XP_005266243.1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Conserved Domains (4) summary
      smart00349
      Location:968
      KRAB; krueppel associated box
      COG5048
      Location:317724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278302
      zf-H2C2_2; Zinc-finger double domain
    8. XM_005266185.2XP_005266242.1  zinc finger protein 84 isoform X1

      See identical proteins and their annotated locations for XP_005266242.1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Related
      ENSP00000437949.1, ENST00000543758.5
      Conserved Domains (4) summary
      smart00349
      Location:968
      KRAB; krueppel associated box
      COG5048
      Location:317724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278302
      zf-H2C2_2; Zinc-finger double domain
    9. XM_047429508.1XP_047285464.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    10. XM_047429510.1XP_047285466.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    11. XM_047429509.1XP_047285465.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      133094846..133120602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373140.1XP_054229115.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    2. XM_054373138.1XP_054229113.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    3. XM_054373136.1XP_054229111.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    4. XM_054373139.1XP_054229114.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    5. XM_054373137.1XP_054229112.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    6. XM_054373135.1XP_054229110.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    7. XM_054373143.1XP_054229118.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    8. XM_054373142.1XP_054229117.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    9. XM_054373141.1XP_054229116.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18