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    RABL2B RAB, member of RAS oncogene family like 2B [ Homo sapiens (human) ]

    Gene ID: 11158, updated on 12-Sep-2024

    Summary

    Official Symbol
    RABL2Bprovided by HGNC
    Official Full Name
    RAB, member of RAS oncogene family like 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:9800
    See related
    Ensembl:ENSG00000079974 MIM:605413; AllianceGenome:HGNC:9800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
    Expression
    Ubiquitous expression in testis (RPKM 7.7), lung (RPKM 6.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    22q13.33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50767506..50783636, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (51281003..51297168, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (51205934..51222064, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:51178129-51178925 Neighboring gene acrosin Neighboring gene SNRPA1 pseudogene 2 Neighboring gene ribosomal protein L23a pseudogene 82 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14005

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ93981, FLJ98216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intraciliary transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003789.3NP_001003789.1  rab-like protein 2B isoform 1

      See identical proteins and their annotated locations for NP_001003789.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      BC014879, BC020495, BC024281, BC040495, BC064551, BG177165
      Consensus CDS
      CCDS33683.1
      UniProtKB/Swiss-Prot
      Q9UNT1
      Related
      ENSP00000346940.3, ENST00000354869.8
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    2. NM_001130919.3NP_001124391.1  rab-like protein 2B isoform 1

      See identical proteins and their annotated locations for NP_001124391.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Variants 1, 3, 4, 5, 8, and 9 all encode the same isoform (1).
      Source sequence(s)
      AC002055, AK308268, BC024281
      Consensus CDS
      CCDS33683.1
      UniProtKB/Swiss-Prot
      Q9UNT1
      Related
      ENSP00000509250.1, ENST00000691320.1
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    3. NM_001130920.3NP_001124392.1  rab-like protein 2B isoform 1

      See identical proteins and their annotated locations for NP_001124392.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding sequence compared to variant 7. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Variants 1, 3, 4, 5, 8 and 9 all encode the same isoform (1).
      Source sequence(s)
      AK313442, BC024281, BX421088
      Consensus CDS
      CCDS33683.1
      UniProtKB/Swiss-Prot
      Q9UNT1
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    4. NM_001130921.3NP_001124393.1  rab-like protein 2B isoform 1

      See identical proteins and their annotated locations for NP_001124393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3. Variants 1, 3, 4, 5, 8 and 9 all encode the same isoform (1).
      Source sequence(s)
      AK313442, BC024281
      Consensus CDS
      CCDS33683.1
      UniProtKB/Swiss-Prot
      Q9UNT1
      Related
      ENSP00000378960.3, ENST00000395595.8
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    5. NM_001130922.3NP_001124394.1  rab-like protein 2B isoform 2

      See identical proteins and their annotated locations for NP_001124394.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3. Variants 2, 6, 10, 11 and 12 all encode the same isoform (2).
      Source sequence(s)
      AK313442, BC024281, BX432293
      Consensus CDS
      CCDS14102.1
      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
      Conserved Domains (1) summary
      cd04124
      Location:22181
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    6. NM_001130923.3NP_001124395.1  rab-like protein 2B isoform 3

      See identical proteins and their annotated locations for NP_001124395.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform 3. Variants 7, 18, 19 and 20 all encode the same isoform (3).
      Source sequence(s)
      AK313442, BC024281, BC075856
      Consensus CDS
      CCDS46738.1
      UniProtKB/Swiss-Prot
      Q9UNT1
      Related
      ENSP00000378958.3, ENST00000395593.7
      Conserved Domains (1) summary
      cd04124
      Location:22191
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    7. NM_001350003.2NP_001336932.1  rab-like protein 2B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AK313442, BC024281, BX421088, DB445642
      Consensus CDS
      CCDS33683.1
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    8. NM_001350004.2NP_001336933.1  rab-like protein 2B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC002055, AK313442, BC024281, BX421088, DB445642
      Consensus CDS
      CCDS33683.1
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    9. NM_001350005.2NP_001336934.1  rab-like protein 2B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK313442, BC024281, DB189975, DB445642
      Consensus CDS
      CCDS14102.1
      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
      Conserved Domains (1) summary
      cd04124
      Location:22181
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    10. NM_001350006.2NP_001336935.1  rab-like protein 2B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AF095352, AK313442, BC024281, BC075856
      Consensus CDS
      CCDS14102.1
      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
      Conserved Domains (1) summary
      cd04124
      Location:22181
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    11. NM_001350007.2NP_001336936.1  rab-like protein 2B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AF095352, AK313442, BC024281, DA156379, DB443254
      Consensus CDS
      CCDS14102.1
      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
      Conserved Domains (1) summary
      cd04124
      Location:22181
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    12. NM_001350008.2NP_001336937.1  rab-like protein 2B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AA312189, AK313442, BC024281, BC075856
      Conserved Domains (1) summary
      cd04124
      Location:22192
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    13. NM_001350009.2NP_001336938.1  rab-like protein 2B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AA312189, AK313442, BC024281, BC075856, DA156379
      Conserved Domains (1) summary
      cd04124
      Location:22192
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    14. NM_001350010.2NP_001336939.1  rab-like protein 2B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AA312189, AK313442, BC024281, BC075856, HY005472
      Conserved Domains (1) summary
      cd04124
      Location:22192
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    15. NM_001350011.2NP_001336940.1  rab-like protein 2B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AA312189, AK313442, BC024281, BC075856, BF435772
      Conserved Domains (1) summary
      cd04124
      Location:22192
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    16. NM_001350012.2NP_001336941.1  rab-like protein 2B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AA312189, AK313442, BC024281, BC075856, DA156379, DB445642
      Conserved Domains (1) summary
      cd04124
      Location:22192
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    17. NM_001350013.2NP_001336942.1  rab-like protein 2B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AK313442, BC024281, BC075856, DB445642
      Consensus CDS
      CCDS46738.1
      Conserved Domains (1) summary
      cd04124
      Location:22191
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    18. NM_001350014.2NP_001336943.1  rab-like protein 2B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AK313442, BC024281, BC075856, DA156379
      Consensus CDS
      CCDS46738.1
      Conserved Domains (1) summary
      cd04124
      Location:22191
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    19. NM_001350015.2NP_001336944.1  rab-like protein 2B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AK313442, BC024281, BC075856, HY005472
      Consensus CDS
      CCDS46738.1
      Conserved Domains (1) summary
      cd04124
      Location:22191
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    20. NM_001350016.2NP_001336945.1  rab-like protein 2B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AA312189, AK313442, BC024281, BC075856, BG677109
      Conserved Domains (1) summary
      cd04124
      Location:22188
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    21. NM_001350017.2NP_001336946.1  rab-like protein 2B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AA312189, AK313442, BC024281, BC075856, BG677109, DA156379, DB443254
      Conserved Domains (1) summary
      cd04124
      Location:22188
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    22. NM_001394054.1NP_001380983.1  rab-like protein 2B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC002055
      Consensus CDS
      CCDS33683.1
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    23. NM_001394055.1NP_001380984.1  rab-like protein 2B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC002055
      Consensus CDS
      CCDS33683.1
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    24. NM_007081.4NP_009012.1  rab-like protein 2B isoform 2

      See identical proteins and their annotated locations for NP_009012.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' UTR and coding sequence compared to variant 7. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3. Variants 2, 6, 10, 11 and 12 all encode the same isoform (2).
      Source sequence(s)
      AF095352, BC024281, BG177165
      Consensus CDS
      CCDS14102.1
      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
      Related
      ENSP00000378962.3, ENST00000395598.7
      Conserved Domains (1) summary
      cd04124
      Location:22181
      RabL2; Rab GTPase-like family 2 (Rab-like2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      50767506..50783636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441092.1XP_047297048.1  rab-like protein 2B isoform X3

    2. XM_047441089.1XP_047297045.1  rab-like protein 2B isoform X2

    3. XM_047441094.1XP_047297050.1  rab-like protein 2B isoform X4

    4. XM_047441093.1XP_047297049.1  rab-like protein 2B isoform X3

    5. XM_017028546.2XP_016884035.1  rab-like protein 2B isoform X1

      Conserved Domains (1) summary
      cd04124
      Location:22192
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    6. XM_017028556.2XP_016884045.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
      Conserved Domains (1) summary
      cd04124
      Location:22181
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    7. XM_017028547.2XP_016884036.1  rab-like protein 2B isoform X2

      UniProtKB/Swiss-Prot
      Q9UNT1
      Conserved Domains (1) summary
      cd04124
      Location:22191
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    8. XM_017028552.2XP_016884041.1  rab-like protein 2B isoform X5

      UniProtKB/Swiss-Prot
      Q9UNT1
      Conserved Domains (1) summary
      cd04124
      Location:22182
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    9. XM_017028543.2XP_016884032.1  rab-like protein 2B isoform X1

      Conserved Domains (1) summary
      cd04124
      Location:22192
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    10. XM_047441098.1XP_047297054.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    11. XM_047441088.1XP_047297044.1  rab-like protein 2B isoform X2

    12. XM_047441095.1XP_047297051.1  rab-like protein 2B isoform X5

    13. XM_047441090.1XP_047297046.1  rab-like protein 2B isoform X3

    14. XM_047441085.1XP_047297041.1  rab-like protein 2B isoform X1

    15. XM_047441097.1XP_047297053.1  rab-like protein 2B isoform X5

    16. XM_047441087.1XP_047297043.1  rab-like protein 2B isoform X1

    17. XM_047441100.1XP_047297056.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    18. XM_017028551.2XP_016884040.1  rab-like protein 2B isoform X4

      Conserved Domains (2) summary
      cd04124
      Location:22187
      RabL2; Rab GTPase-like family 2 (Rab-like2)
      smart00175
      Location:22166
      RAB; Rab subfamily of small GTPases
    19. XM_047441086.1XP_047297042.1  rab-like protein 2B isoform X1

    20. XM_047441096.1XP_047297052.1  rab-like protein 2B isoform X5

    21. XM_047441099.1XP_047297055.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    22. XM_047441091.1XP_047297047.1  rab-like protein 2B isoform X3

    23. XM_017028544.2XP_016884033.1  rab-like protein 2B isoform X1

      Conserved Domains (1) summary
      cd04124
      Location:22192
      RabL2; Rab GTPase-like family 2 (Rab-like2)
    24. XM_047441101.1XP_047297057.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    25. XM_047441102.1XP_047297058.1  rab-like protein 2B isoform X7

    26. XM_047441103.1XP_047297059.1  rab-like protein 2B isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      51281003..51297168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325029.1XP_054181004.1  rab-like protein 2B isoform X5

    2. XM_054325015.1XP_054180990.1  rab-like protein 2B isoform X1

    3. XM_054325023.1XP_054180998.1  rab-like protein 2B isoform X3

    4. XM_054325019.1XP_054180994.1  rab-like protein 2B isoform X2

    5. XM_054325025.1XP_054181000.1  rab-like protein 2B isoform X4

    6. XM_054325024.1XP_054180999.1  rab-like protein 2B isoform X3

    7. XM_054325017.1XP_054180992.1  rab-like protein 2B isoform X1

    8. XM_054325032.1XP_054181007.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    9. XM_054325020.1XP_054180995.1  rab-like protein 2B isoform X2

    10. XM_054325027.1XP_054181002.1  rab-like protein 2B isoform X5

    11. XM_054325013.1XP_054180988.1  rab-like protein 2B isoform X1

    12. XM_054325030.1XP_054181005.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    13. XM_054325018.1XP_054180993.1  rab-like protein 2B isoform X2

    14. XM_054325026.1XP_054181001.1  rab-like protein 2B isoform X5

    15. XM_054325021.1XP_054180996.1  rab-like protein 2B isoform X3

    16. XM_054325011.1XP_054180986.1  rab-like protein 2B isoform X1

    17. XM_054325033.1XP_054181008.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    18. XM_054325014.1XP_054180989.1  rab-like protein 2B isoform X1

    19. XM_054325028.1XP_054181003.1  rab-like protein 2B isoform X5

    20. XM_054325031.1XP_054181006.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    21. XM_054325022.1XP_054180997.1  rab-like protein 2B isoform X3

    22. XM_054325012.1XP_054180987.1  rab-like protein 2B isoform X1

    23. XM_054325034.1XP_054181009.1  rab-like protein 2B isoform X6

      UniProtKB/Swiss-Prot
      Q5TZT8, Q96C33, Q9UNT1
      UniProtKB/TrEMBL
      A0A0S2SW46
    24. XM_054325016.1XP_054180991.1  rab-like protein 2B isoform X1

    25. XM_054325035.1XP_054181010.1  rab-like protein 2B isoform X7

    26. XM_054325036.1XP_054181011.1  rab-like protein 2B isoform X7