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    Gins3 GINS complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 78833, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gins3provided by MGI
    Official Full Name
    GINS complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1926083
    See related
    Ensembl:ENSMUSG00000031669 AllianceGenome:MGI:1926083
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psf3; 2700085M18Rik
    Summary
    Predicted to be involved in DNA unwinding involved in DNA replication and mitotic DNA replication initiation. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and GINS complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human GINS3 (GINS complex subunit 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.4), liver E14 (RPKM 3.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gins3 in Genome Data Viewer
    Location:
    8 D1; 8 47.12 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96360187..96371687)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95633559..95645059)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene G patch domain and KOW motifs pseudogene Neighboring gene STARR-seq mESC enhancer starr_22391 Neighboring gene predicted gene, 31518 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:98157360-98157469 Neighboring gene predicted gene, 39230 Neighboring gene predicted gene, 42037

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome. McQuaid ME, et al. JCI Insight, 2022 May 23. PMID 35603789, Free PMC Article
    2. A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS. Hayashi R, et al. Genomics Proteomics Bioinformatics, 2006 Aug. PMID 17127213, Free PMC Article
    3. A key role for the GINS complex at DNA replication forks. Labib K, et al. Trends Cell Biol, 2007 Jun. PMID 17467990
    4. Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase. Fujisawa R, et al. Elife, 2022 Aug 3. PMID 35920641, Free PMC Article
    5. CUL2(LRR1) , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. Villa F, et al. EMBO Rep, 2021 Mar 3. PMID 33590678, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome.
      Title: Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome.
    2. expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1
      Title: A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA unwinding involved in DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication complex GINS protein PSF3
    Names
    GINS complex subunit 3 (Psf3 homolog)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030198.3 → NP_084474.1  DNA replication complex GINS protein PSF3

      See identical proteins and their annotated locations for NP_084474.1

      Status: PROVISIONAL

      Source sequence(s)
      AC113951
      Consensus CDS
      CCDS22564.1
      UniProtKB/Swiss-Prot
      Q9CY94
      Related
      ENSMUSP00000034094.9, ENSMUST00000034094.11
      Conserved Domains (1) summary
      cd11713
      Location:83 → 192
      GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96360187..96371687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY94.1 GenPept UniProtKB/Swiss-Prot:Q9CY94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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