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    Dnai3 dynein axonemal intermediate chain 3 [ Mus musculus (house mouse) ]

    Gene ID: 242253, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Dnai3provided by MGI
    Official Full Name
    dynein axonemal intermediate chain 3provided by MGI
    Primary source
    MGI:MGI:3045269
    See related
    Ensembl:ENSMUSG00000043020 AllianceGenome:MGI:3045269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ida7; IC140; Wdr63; 4931433A13Rik
    Summary
    Predicted to enable Arp2/3 complex binding activity; dynein heavy chain binding activity; and dynein light chain binding activity. Involved in positive regulation of osteoblast differentiation. Part of axonemal dynein complex. Is expressed in choroid plexus; lung epithelium; node; and sensory organ. Orthologous to human DNAI3 (dynein axonemal intermediate chain 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis adult (RPKM 12.4), lung adult (RPKM 1.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Dnai3 in Genome Data Viewer
    Location:
    3 H2; 3 71.03 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145746281..145813855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146040526..146108100, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09212 Neighboring gene synapse defective 1, Rho GTPase, homolog 2 (C. elegans) Neighboring gene predicted gene, 40166 Neighboring gene STARR-seq mESC enhancer starr_09216 Neighboring gene predicted gene, 35409 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:145726222-145726405 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145770955-145771256 Neighboring gene mucolipin 3 Neighboring gene predicted gene, 25627 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145797888-145798188 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145815297-145815597 Neighboring gene mucolipin 2 Neighboring gene STARR-positive B cell enhancer ABC_E9580 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145847906-145848206

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced osteogenic differentiation potentials of stem cells from apical papilla. Diao S, et al. J Endod, 2015 Feb. PMID 25498833
    2. WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis. Zhao K, et al. EMBO Rep, 2020 Apr 3. PMID 32128961, Free PMC Article
    3. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. Young SA, et al. Int J Mol Sci, 2015 Oct 16. PMID 26501274, Free PMC Article
    4. Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. Zhang Y, et al. J Mol Cell Biol, 2019 May 1. PMID 30060180, Free PMC Article
    5. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. Takeda S, et al. J Cell Biol, 1999 May 17. PMID 10330409, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.
      Title: WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Arp2/3 complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of axonemal dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal intermediate chain 3
    Names
    WD repeat domain 63
    WD repeat-containing protein 63
    dynein intermediate chain 3, axonemal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172864.3 → NP_766452.2  dynein axonemal intermediate chain 3

      See identical proteins and their annotated locations for NP_766452.2

      Status: VALIDATED

      Source sequence(s)
      AK029903, BX631982
      Consensus CDS
      CCDS17899.2
      UniProtKB/Swiss-Prot
      B2RY71
      Related
      ENSMUSP00000124475.2, ENSMUST00000160285.2
      Conserved Domains (1) summary
      COG2319
      Location:384 → 532
      WD40; WD40 repeat [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      145746281..145813855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319579.3 → XP_017175068.1  dynein axonemal intermediate chain 3 isoform X1

      UniProtKB/TrEMBL
      Q8C0T4
      Conserved Domains (1) summary
      COG2319
      Location:198 → 346
      WD40; WD40 repeat [General function prediction only]

    RNA

    1. XR_867216.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RY71.1 GenPept UniProtKB/Swiss-Prot:B2RY71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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