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    Mecr mitochondrial trans-2-enoyl-CoA reductase [ Mus musculus (house mouse) ]

    Gene ID: 26922, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mecrprovided by MGI
    Official Full Name
    mitochondrial trans-2-enoyl-CoA reductaseprovided by MGI
    Primary source
    MGI:MGI:1349441
    See related
    Ensembl:ENSMUSG00000028910 AllianceGenome:MGI:1349441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrbf1; NRBF-1
    Summary
    Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity; nuclear receptor binding activity; and signaling receptor binding activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in submandibular gland primordium. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.0), colon adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mecr in Genome Data Viewer
    Location:
    4 D2.3; 4 64.52 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131570755..131595097)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131843444..131867787)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11548 Neighboring gene predicted gene, 42321 Neighboring gene protein tyrosine phosphatase receptor type U Neighboring gene predicted gene, 52680 Neighboring gene STARR-positive B cell enhancer ABC_E10262 Neighboring gene serine and arginine-rich splicing factor 4 Neighboring gene predicted gene 12992 Neighboring gene phosphatidylinositol 3-kinase, catalytic, beta polypeptide pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance. Qian S, et al. Biosci Rep, 2020 Jun 26. PMID 32440681, Free PMC Article
    2. Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice. Nair RR, et al. J Neurosci, 2018 Nov 7. PMID 30266742, Free PMC Article
    3. Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. Chen Z, et al. PLoS One, 2009. PMID 19440339, Free PMC Article
    4. Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. Chen ZJ, et al. J Mol Biol, 2008 Jun 13. PMID 18479707
    5. Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Nair RR, et al. Hum Mol Genet, 2017 Jun 1. PMID 28369354

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance.
      Title: ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance.
    2. The results showed a ventricular dilatation behind impaired heart function upon Mecr overexpression, concurrent with appearance of dysmorphic mitochondria
      Title: Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of ceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intracellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enoyl-[acyl-carrier-protein] reductase, mitochondrial
    Names
    2-enoyl thioester reductase
    nuclear receptor binding factor 1
    trans-2-enoyl-CoA reductase, mitochondrial
    NP_001411880.1
    NP_001411881.1
    NP_001411882.1
    NP_001411883.1
    NP_001411884.1
    NP_079573.2
    XP_006538952.1
    XP_011248563.1
    XP_011248564.1
    XP_011248565.1
    XP_036020030.1
    XP_036020031.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424951.1 → NP_001411880.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL607088, AL670959

    2. NM_001424952.1 → NP_001411881.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL607088, AL670959

    3. NM_001424953.1 → NP_001411882.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL607088, AL670959

    4. NM_001424954.1 → NP_001411883.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL607088, AL670959

    5. NM_001424955.1 → NP_001411884.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL607088, AL670959

    6. NM_025297.3 → NP_079573.2  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_079573.2

      Status: VALIDATED

      Source sequence(s)
      AL607088, AL670959
      Consensus CDS
      CCDS18715.1
      UniProtKB/Swiss-Prot
      Q99L39, Q9DCS3
      Related
      ENSMUSP00000030742.5, ENSMUST00000030742.11
      Conserved Domains (2) summary
      cd08290
      Location:44 → 373
      ETR; 2-enoyl thioester reductase (ETR)
      COG0604
      Location:44 → 350
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    RNA

    1. NR_188987.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL607088, AL670959

    2. NR_188988.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL607088, AL670959

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      131570755..131595097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250261.2 → XP_011248563.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011248563.1

      Conserved Domains (1) summary
      cd08290
      Location:22 → 336
      ETR; 2-enoyl thioester reductase (ETR)

    2. XM_036164138.1 → XP_036020031.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd08290
      Location:1 → 297
      ETR; 2-enoyl thioester reductase (ETR)

    3. XM_036164137.1 → XP_036020030.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd08290
      Location:1 → 297
      ETR; 2-enoyl thioester reductase (ETR)

    4. XM_006538889.3 → XP_006538952.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006538952.1

      Conserved Domains (1) summary
      cd08290
      Location:22 → 336
      ETR; 2-enoyl thioester reductase (ETR)

    5. XM_011250262.2 → XP_011248564.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011248564.1

      Conserved Domains (1) summary
      cd08290
      Location:22 → 336
      ETR; 2-enoyl thioester reductase (ETR)

    6. XM_011250263.2 → XP_011248565.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011248565.1

      Conserved Domains (1) summary
      cd08290
      Location:22 → 336
      ETR; 2-enoyl thioester reductase (ETR)

    RNA

    1. XR_001784149.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCS3.2 GenPept UniProtKB/Swiss-Prot:Q9DCS3

    Gene LinkOut

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