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    Polr3f polymerase (RNA) III (DNA directed) polypeptide F [ Mus musculus (house mouse) ]

    Gene ID: 70408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr3fprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Fprovided by MGI
    Primary source
    MGI:MGI:1924086
    See related
    Ensembl:ENSMUSG00000027427 AllianceGenome:MGI:1924086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPC6; RPC39; 2810411G20Rik; 3010019O03Rik; 3110032A07Rik
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and double-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human POLR3F (RNA polymerase III subunit F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E14 (RPKM 4.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr3f in Genome Data Viewer
    Location:
    2 G1; 2 71.02 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144369665..144383699)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144527745..144541779)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 133, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05917 Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene STARR-seq mESC enhancer starr_05918 Neighboring gene retinoblastoma binding protein 9, serine hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E1603 Neighboring gene predicted gene, 34292 Neighboring gene SEC23 homolog B, COPII coat complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. Jones E, et al. Exp Cell Res, 2000 Jan 10. PMID 10623476
    2. Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice. Sheehan S, et al. Am J Physiol Renal Physiol, 2007 Nov. PMID 17804484
    3. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. Wang Z, et al. Genes Dev, 1997 May 15. PMID 9171375
    4. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Chiu S, et al. Physiol Genomics, 2007 Sep 19. PMID 17536020
    5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11656

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC6
    Names
    DNA-directed RNA polymerase III subunit F
    RNA polymerase III subunit C6
    NP_084039.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029763.3 → NP_084039.2  DNA-directed RNA polymerase III subunit RPC6

      See identical proteins and their annotated locations for NP_084039.2

      Status: VALIDATED

      Source sequence(s)
      AK029286, AK036166
      Consensus CDS
      CCDS16820.1
      UniProtKB/Swiss-Prot
      Q544K6, Q921X6
      UniProtKB/TrEMBL
      Q8C108
      Related
      ENSMUSP00000028914.3, ENSMUST00000028914.9
      Conserved Domains (1) summary
      pfam05158
      Location:12 → 315
      RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      144369665..144383699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027417.1: Suppressed sequence

      Description
      NM_027417.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921X6.1 GenPept UniProtKB/Swiss-Prot:Q921X6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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