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    Tg thyroglobulin [ Mus musculus (house mouse) ]

    Gene ID: 21819, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tgprovided by MGI
    Official Full Name
    thyroglobulinprovided by MGI
    Primary source
    MGI:MGI:98733
    See related
    Ensembl:ENSMUSG00000053469 AllianceGenome:MGI:98733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tgn; cog
    Summary
    Enables identical protein binding activity. Involved in thyroid hormone generation. Acts upstream of or within iodide transport; regulation of myelination; and thyroid hormone metabolic process. Located in extracellular space. Is expressed in thyroid gland; thyroid gland follicle; thyroid gland left lobe colloid-filled follicles; thyroid gland lobe; and thyroid gland right lobe colloid-filled follicles. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in autoimmune disease of endocrine system (multiple); goiter; liver disease (multiple); and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.0), genital fat pad adult (RPKM 0.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D2; 15 29.3 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (66542606..66722570)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (66670754..66850721)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 71 Neighboring gene STARR-positive B cell enhancer mm9_chr15:66392494-66392795 Neighboring gene PHD finger protein 20-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr15:66511565-66511866 Neighboring gene STARR-positive B cell enhancer mm9_chr15:66616909-66617209 Neighboring gene STARR-positive B cell enhancer ABC_E5484 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:66650248-66650357 Neighboring gene VISTA enhancer mm104 Neighboring gene src-like adaptor Neighboring gene STARR-positive B cell enhancer ABC_E5485 Neighboring gene predicted gene, 46514 Neighboring gene cellular communication network factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An endoplasmic reticulum storage disease causing congenital goiter with hypothyroidism. Kim PS, et al. J Cell Biol, 1996 May. PMID 8636228, Free PMC Article
    2. Maturation of thyroglobulin protein region I. Lee J, et al. J Biol Chem, 2011 Sep 23. PMID 21816825, Free PMC Article
    3. Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis. Kolypetri P, et al. Hormones (Athens), 2010 Apr-Jun. PMID 20687399
    4. The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis. Kolypetri P, et al. J Immunol, 2014 Jul 1. PMID 24879795
    5. Evaluation of thyroglobulin expression in murine reproductive organs during pregnancy. Moravej A, et al. Am J Reprod Immunol, 2010 Aug 1. PMID 20236260

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
      Title: Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
    2. Thyrocyte cell survival and adaptation to chronic endoplasmic reticulum stress due to misfolded thyroglobulin.
      Title: Thyrocyte cell survival and adaptation to chronic endoplasmic reticulum stress due to misfolded thyroglobulin.
    3. antepenultimate residue of TG as a major T3-forming site, but also demonstrate that the side chain of this residue intimately interacts with the same residue in the apposed monomer of the TG dimer.
      Title: Relationship between the dimerization of thyroglobulin and its ability to form triiodothyronine.
    4. Findings suggest that coumestrol treatment may have some beneficial actions against thyroid-specific thyroglobulin (Tg) autoantibody production in the development of autoimmune thyroiditis through suppression of Th1 response.
      Title: Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis.
    5. these data identify for the first time a Tg T cell epitope as a spontaneous target in ISAT.
      Title: The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis.
    6. Final acquisition of secretory competence includes conformational maturation in the interval between linker and hinge segments of region I of thyroglobulin.
      Title: Maturation of thyroglobulin protein region I.
    7. The results showed that thyroglobulin message or protein is not expressed in placenta, decidua, or ovary in any stages of pregnancy.
      Title: Evaluation of thyroglobulin expression in murine reproductive organs during pregnancy.
    8. Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO.
      Title: Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.
    9. These results indicate that Runx2 deficiency in mice causes decreased Tg expression and a novel type of hypothyroidism.
      Title: Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism.
    10. Development of iodine-accelerated autoimmune thyroiditis in NOD.H2h4 mice is not associated with enhanced iodine organification or differential B- or T-cell responses to iodinated determinants in Tg.
      Title: Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (7)  1 citation
    • Endonuclease-mediated (5)  1 citation
    • Spontaneous (1) 
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117699

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iodide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid hormone generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone generation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within thyroid hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thyroglobulin
    Names
    congenital goiter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009375.2 → NP_033401.2  thyroglobulin precursor

      See identical proteins and their annotated locations for NP_033401.2

      Status: VALIDATED

      Source sequence(s)
      BC111467, CK788949, CK789624, U76389
      Consensus CDS
      CCDS37091.1
      UniProtKB/Swiss-Prot
      O08710, O88590, Q2NKY1, Q9QWY7
      Related
      ENSMUSP00000070239.8, ENSMUST00000065916.14
      Conserved Domains (5) summary
      smart00211
      Location:1519 → 1566
      TY; Thyroglobulin type I repeats
      cd00191
      Location:96 → 161
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00135
      Location:2192 → 2717
      COesterase; Carboxylesterase family
      pfam07699
      Location:1464 → 1509
      GCC2_GCC3; GCC2 and GCC3
      cl00150
      Location:893 → 922
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      66542606..66722570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520745.4 → XP_006520808.2  thyroglobulin isoform X1

      Conserved Domains (5) summary
      smart00211
      Location:1519 → 1566
      TY; Thyroglobulin type I repeats
      cd00191
      Location:96 → 161
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam07699
      Location:1464 → 1509
      Ephrin_rec_like; Putative ephrin-receptor like
      pfam00135
      Location:2198 → 2717
      COesterase; Carboxylesterase family
      cl00150
      Location:893 → 922
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    RNA

    1. XR_004938813.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08710.3 GenPept UniProtKB/Swiss-Prot:O08710

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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