Terc telomerase RNA component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tercprovided by MGI
Official Full Name: telomerase RNA componentprovided by MGI
Primary source: MGI:MGI:109558
See related: Ensembl:ENSMUSG00000118406 AllianceGenome:MGI:109558
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mTR; mTER
Summary: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human telomerase, murine telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]
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Genomic context

Location:: 3 F2.1; 3 41.82 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (96321753..96322149, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (96414437..96414833, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice.
Title: Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice.
TERC association with mTor pathway and its role in aging.
Title: The mTOR pathway is necessary for survival of mice with short telomeres.
The authors show that cytosolic TERC-53 is involved in cognition decline in 10 months old mouse hippocampus without affecting telomerase activity or mitochondrial functions, possibly through regulating nuclear gene expression.
Title: Mitochondrion-processed TERC regulates senescence without affecting telomerase activities.
The telomere lengths are longest in wild-type but shortest in Terc(-/-) ntESCs.
Title: Compromised Chondrocyte Differentiation Capacity in TERC Knockout Mouse Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer.
Mechanistically, Gadd45a facilitates the generation of a permissive chromatin state for DNA damage response (DDR) signaling by inducing base excision repair-dependent demethylation of CpG islands specifically at sub-telomeric regions of short telomeres. Deletion of Gadd45a promotes chromatin compaction in sub-telomeric regions and attenuates DDR initiation at short telomeres of G3Terc (-/-) ISCs
Title: Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan.
Expression of functional alternative telomerase RNA component gene in the mouse brain provides an additional way for regulating telomerase activity under normal and stress conditions and confers protection to neuronal cells from oxidative stress.
Title: Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress.
The lack of telomerase produce specific phenotypes, some of which can be prevented by dietary restriction.
Title: Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype.
genetic deletion in a mouse acute myeloid leukemia model induces cell-cycle arrest and apoptosis of leukemia stem cells
Title: Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.
Knockdown of TERC recapitulates the dyskeratosis congenita-bone marrow stem cells phenotype.
Title: Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.
We show that basal cells in the epidermis maintain telomeres both by telomerase and alternative lengthening of telomere (ALT) mechanisms in vivo.
Title: Alternative lengthening of telomeres in cancer stem cells in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC122568P1 (e-PCR)
- UniSTS:270397

PMC154048P1 (e-PCR)
- UniSTS:271288

PMC154048P2 (e-PCR)
- UniSTS:271289

NoName (e-PCR)
- UniSTS:493011

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables telomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within telomere maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.