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    S100A3 S100 calcium binding protein A3 [ Homo sapiens (human) ]

    Gene ID: 6274, updated on 9-Dec-2024

    Summary

    Official Symbol
    S100A3provided by HGNC
    Official Full Name
    S100 calcium binding protein A3provided by HGNC
    Primary source
    HGNC:HGNC:10493
    See related
    Ensembl:ENSG00000188015 MIM:176992; AllianceGenome:HGNC:10493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S100E
    Summary
    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lung (RPKM 11.5), skin (RPKM 3.7) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See S100A3 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153547329..153549258, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152684585..152686514, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153519805..153521734, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153508457-153509092 Neighboring gene S100 calcium binding protein A6 Neighboring gene S100 calcium binding protein A5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153517191-153517771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153517772-153518352 Neighboring gene uncharacterized LOC101928034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153521261-153521822 Neighboring gene Sharpr-MPRA regulatory region 14368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153522386-153522947 Neighboring gene S100 calcium binding protein A4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153536677-153537434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153537435-153538192 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:153538345-153539544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153539708-153540464 Neighboring gene S100 calcium binding protein A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153546964-153547744 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153547745-153548525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153550484-153551282 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153555559-153556483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153577506-153578461 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:153580804-153582003 Neighboring gene S100 calcium binding protein A16

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: S100A4

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046928.1 RefSeqGene

      Range
      5001..6930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002960.2NP_002951.1  protein S100-A3

      See identical proteins and their annotated locations for NP_002951.1

      Status: REVIEWED

      Source sequence(s)
      BX470102, Z18948
      Consensus CDS
      CCDS1043.1
      UniProtKB/Swiss-Prot
      D3DV51, P33764, Q6FGE4
      Related
      ENSP00000357702.3, ENST00000368713.8
      Conserved Domains (1) summary
      cd00213
      Location:490
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153547329..153549258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      152684585..152686514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)