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    TRAF3 TNF receptor associated factor 3 [ Homo sapiens (human) ]

    Gene ID: 7187, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRAF3provided by HGNC
    Official Full Name
    TNF receptor associated factor 3provided by HGNC
    Primary source
    HGNC:HGNC:12033
    See related
    Ensembl:ENSG00000131323 MIM:601896; AllianceGenome:HGNC:12033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP1; LAP1; CAP-1; CRAF1; IIAE5; CD40bp; RNF118
    Summary
    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in lymph node (RPKM 5.0), appendix (RPKM 4.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRAF3 in Genome Data Viewer
    Location:
    14q32.32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102777449..102911500)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97013797..97147747)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103243786..103377837)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene REST corepressor 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103129073-103129810 Neighboring gene ribosomal protein L23a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9077 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103174038-103175237 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103188411-103189610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103204471-103204972 Neighboring gene uncharacterized LOC124903390 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103213106-103213279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103216089-103216923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103224133-103224633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103236826-103237330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103237331-103237835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6131 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103249335-103249487 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9085 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103276021-103276180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103294403-103294902 Neighboring gene NANOG hESC enhancer GRCh37_chr14:103307110-103307650 Neighboring gene RNA, U6 small nuclear 1316, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:103352003-103353202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103357046-103357546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103357547-103358047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103366521-103367022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103367023-103367522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103379429-103380018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103380019-103380608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103380952-103381452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6134 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103390587-103390785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6136 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:103411482-103412681 Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnion associated transmembrane protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103452779-103453413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103453414-103454047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103464738-103465284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9093 Neighboring gene Sharpr-MPRA regulatory region 6354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103486267-103486822 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103489632-103489899 Neighboring gene Sharpr-MPRA regulatory region 14595 Neighboring gene ribosomal protein L13 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke. Gallego-Fabrega C, et al. Stroke, 2016 May. PMID 27026631
    2. TRAF3 alterations are frequent in del-3'IGH chronic lymphocytic leukemia patients and define a specific subgroup with adverse clinical features. Pérez-Carretero C, et al. Am J Hematol, 2022 Jul. PMID 35472012
    3. LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3. Wu S, et al. J Biol Chem, 2005 Sep 30. PMID 16009714
    4. CD40 polymorphism in cervical carcinoma in a subset of Malaysian population. Krishnappa P, et al. J Obstet Gynaecol Res, 2017 May. PMID 28181356
    5. The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis. Lee DY, et al. Blood, 2008 Feb 15. PMID 18042799, Free PMC Article

    See all (343) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRAF3 loss-of-function reveals the noncanonical NF-kappaB pathway as a therapeutic target in diffuse large B cell lymphoma.
      Title: TRAF3 loss-of-function reveals the noncanonical NF-κB pathway as a therapeutic target in diffuse large B cell lymphoma.
    2. FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3.
      Title: FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3.
    3. The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-beta1-induced BEAS-2B Cell Injury.
      Title: The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury.
    4. Effects of TRAF3 on the proliferation and migration of lung adenocarcinoma depend partly on pyroptosis.
      Title: Effects of TRAF3 on the proliferation and migration of lung adenocarcinoma depend partly on pyroptosis.
    5. TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.
      Title: TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.
    6. Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis.
      Title: Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis.
    7. LncRNA XIST Exacerbates Oxygen-Glucose Deprivation/Reoxygenation-Induced Cerebral Injury Through the miR-25-3p/TRAF3 Axis.
      Title: LncRNA XIST Exacerbates Oxygen-Glucose Deprivation/Reoxygenation-Induced Cerebral Injury Through the miR-25-3p/TRAF3 Axis.
    8. TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
      Title: TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
    9. Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
      Title: Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
    10. Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury.
      Title: Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury.
    Submit: New GeneRIF Correction See all GeneRIFs (140)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Herpes simplex encephalitis, susceptibility to, 3
    MedGen: C3553868 OMIM: 614849 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells PubMed
    tat HIV-1 Tat-induced upregulation of microRNA 32 results in downregulation of TRAF3 in human microglial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioesterase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in Toll signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of serine/threonine protein kinase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TNF receptor-associated factor 3
    Names
    CD40 associated protein 1
    CD40 binding protein
    CD40 receptor associated factor 1
    LMP1-associated protein 1
    RING-type E3 ubiquitin transferase TRAF3
    NP_001186356.1
    NP_001372071.1
    NP_001372072.1
    NP_003291.2
    NP_663777.1
    NP_663778.1
    XP_011535418.1
    XP_011535419.1
    XP_011535420.1
    XP_016877106.1
    XP_016877107.1
    XP_016877108.1
    XP_016877109.1
    XP_047287694.1
    XP_047287695.1
    XP_047287696.1
    XP_047287697.1
    XP_047287698.1
    XP_054232638.1
    XP_054232639.1
    XP_054232640.1
    XP_054232641.1
    XP_054232642.1
    XP_054232643.1
    XP_054232644.1
    XP_054232645.1
    XP_054232646.1
    XP_054232647.1
    XP_054232648.1
    XP_054232649.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027973.1 RefSeqGene

      Range
      5001..139022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_229

    mRNA and Protein(s)

    1. NM_001199427.2 → NP_001186356.1  TNF receptor-associated factor 3 isoform 3

      See identical proteins and their annotated locations for NP_001186356.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region as compared to isoform 1.
      Source sequence(s)
      AK303172, AL117209, AL132801, BQ000015, U21092
      Consensus CDS
      CCDS55946.1
      UniProtKB/Swiss-Prot
      Q13114
      Related
      ENSP00000445998.1, ENST00000539721.5
      Conserved Domains (4) summary
      smart00184
      Location:53 → 88
      RING; Ring finger
      cd03777
      Location:295 → 480
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 190
      zf-TRAF; TRAF-type zinc finger
      pfam17082
      Location:224 → 283
      Spc29; Spindle Pole Component 29

    2. NM_001385142.1 → NP_001372071.1  TNF receptor-associated factor 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL117209, AL132801
      Conserved Domains (4) summary
      cd03777
      Location:331 → 516
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
      cl40617
      Location:197 → 247
      zf-TRAF; TRAF-type zinc finger

    3. NM_001385143.1 → NP_001372072.1  TNF receptor-associated factor 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL117209, AL132801
      Related
      ENST00000699895.1
      Conserved Domains (4) summary
      COG1196
      Location:225 → 406
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:351 → 536
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 190
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

    4. NM_003300.4 → NP_003291.2  TNF receptor-associated factor 3 isoform 1

      See identical proteins and their annotated locations for NP_003291.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL117209, AL132801, BQ000015, BX247977, U21092
      Consensus CDS
      CCDS9975.1
      UniProtKB/Swiss-Prot
      B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
      Related
      ENSP00000454207.1, ENST00000560371.5
      Conserved Domains (5) summary
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:56 → 91
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      pfam15272
      Location:263 → 321
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17082
      Location:307 → 366
      Spc29; Spindle Pole Component 29

    5. NM_145725.3 → NP_663777.1  TNF receptor-associated factor 3 isoform 1

      See identical proteins and their annotated locations for NP_663777.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL117209, AL132801, BQ000015, BX247977, U21092
      Consensus CDS
      CCDS9975.1
      UniProtKB/Swiss-Prot
      B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
      Related
      ENSP00000376500.3, ENST00000392745.8
      Conserved Domains (5) summary
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:56 → 91
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      pfam15272
      Location:263 → 321
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17082
      Location:307 → 366
      Spc29; Spindle Pole Component 29

    6. NM_145726.3 → NP_663778.1  TNF receptor-associated factor 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region compared to isoform 1.
      Source sequence(s)
      AL117209, AL132801, BQ000015, BX247977, U21092
      Consensus CDS
      CCDS9976.1
      UniProtKB/TrEMBL
      A6NHG8
      Related
      ENSP00000332468.5, ENST00000351691.10
      Conserved Domains (4) summary
      cd03777
      Location:353 → 538
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR04527
      Location:235 → 361
      mycoplas_twoTM; two transmembrane protein
      pfam00097
      Location:56 → 91
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      102777449..102911500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537117.4 → XP_011535419.1  TNF receptor-associated factor 3 isoform X4

      Conserved Domains (4) summary
      cd03777
      Location:322 → 507
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:56 → 91
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      pfam17082
      Location:251 → 310
      Spc29; Spindle Pole Component 29

    2. XM_011537116.4 → XP_011535418.1  TNF receptor-associated factor 3 isoform X3

      Conserved Domains (4) summary
      smart00184
      Location:53 → 88
      RING; Ring finger
      cd03777
      Location:326 → 511
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR04527
      Location:208 → 334
      mycoplas_twoTM; two transmembrane protein
      pfam02176
      Location:136 → 190
      zf-TRAF; TRAF-type zinc finger

    3. XM_011537118.4 → XP_011535420.1  TNF receptor-associated factor 3 isoform X5

      See identical proteins and their annotated locations for XP_011535420.1

      UniProtKB/Swiss-Prot
      Q13114
      Conserved Domains (4) summary
      smart00184
      Location:53 → 88
      RING; Ring finger
      cd03777
      Location:295 → 480
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 190
      zf-TRAF; TRAF-type zinc finger
      pfam17082
      Location:224 → 283
      Spc29; Spindle Pole Component 29

    4. XM_047431739.1 → XP_047287695.1  TNF receptor-associated factor 3 isoform X2

      UniProtKB/TrEMBL
      A6NHG8

    5. XM_047431742.1 → XP_047287698.1  TNF receptor-associated factor 3 isoform X4

    6. XM_047431740.1 → XP_047287696.1  TNF receptor-associated factor 3 isoform X3

    7. XM_017021620.3 → XP_016877109.1  TNF receptor-associated factor 3 isoform X6

    8. XM_017021617.2 → XP_016877106.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
      Conserved Domains (5) summary
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:56 → 91
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      pfam15272
      Location:263 → 321
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17082
      Location:307 → 366
      Spc29; Spindle Pole Component 29

    9. XM_047431738.1 → XP_047287694.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

    10. XM_017021618.2 → XP_016877107.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
      Related
      ENSP00000514678.1, ENST00000699894.1
      Conserved Domains (5) summary
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam00097
      Location:56 → 91
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      pfam15272
      Location:263 → 321
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17082
      Location:307 → 366
      Spc29; Spindle Pole Component 29

    11. XM_017021619.2 → XP_016877108.1  TNF receptor-associated factor 3 isoform X2

      UniProtKB/TrEMBL
      A6NHG8
      Related
      ENSP00000514677.1, ENST00000699893.1
      Conserved Domains (4) summary
      cd03777
      Location:353 → 538
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      TIGR04527
      Location:235 → 361
      mycoplas_twoTM; two transmembrane protein
      pfam00097
      Location:56 → 91
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger

    12. XM_047431741.1 → XP_047287697.1  TNF receptor-associated factor 3 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      97013797..97147747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376670.1 → XP_054232645.1  TNF receptor-associated factor 3 isoform X4

    2. XM_054376668.1 → XP_054232643.1  TNF receptor-associated factor 3 isoform X3

    3. XM_054376673.1 → XP_054232648.1  TNF receptor-associated factor 3 isoform X5

    4. XM_054376667.1 → XP_054232642.1  TNF receptor-associated factor 3 isoform X2

      UniProtKB/TrEMBL
      A6NHG8

    5. XM_054376672.1 → XP_054232647.1  TNF receptor-associated factor 3 isoform X4

    6. XM_054376669.1 → XP_054232644.1  TNF receptor-associated factor 3 isoform X3

    7. XM_054376674.1 → XP_054232649.1  TNF receptor-associated factor 3 isoform X6

    8. XM_054376664.1 → XP_054232639.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

    9. XM_054376665.1 → XP_054232640.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

    10. XM_054376666.1 → XP_054232641.1  TNF receptor-associated factor 3 isoform X2

      UniProtKB/TrEMBL
      A6NHG8

    11. XM_054376671.1 → XP_054232646.1  TNF receptor-associated factor 3 isoform X4

    12. XM_054376663.1 → XP_054232638.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/Swiss-Prot
      B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13114.2 GenPept UniProtKB/Swiss-Prot:Q13114

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