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    DYNLT4 dynein light chain Tctex-type 4 [ Homo sapiens (human) ]

    Gene ID: 343521, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DYNLT4provided by HGNC
    Official Full Name
    dynein light chain Tctex-type 4provided by HGNC
    Primary source
    HGNC:HGNC:32315
    See related
    Ensembl:ENSG00000188396 MIM:611713; AllianceGenome:HGNC:32315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCTEX1D4
    Summary
    Enables protein phosphatase 1 binding activity. Predicted to be involved in microtubule-based movement. Located in several cellular components, including acrosomal vesicle; cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 3.3), appendix (RPKM 2.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DYNLT4 in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44805893..44807351, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44677047..44678505, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45271565..45273023, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45245573-45246073 Neighboring gene ribosomal protein S15a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45251699-45252384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45252385-45253070 Neighboring gene bestrophin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45257343-45258034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45258727-45259416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45265053-45265721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45271492-45272342 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:45272786-45273985 Neighboring gene polo like kinase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45274044-45274893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 953 Neighboring gene BTB domain containing 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 821 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:45284771-45285427 and GRCh37_chr1:45285428-45286084 Neighboring gene RNA, U5E small nuclear 6, pseudogene Neighboring gene patched 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa. Freitas MJ, et al. OMICS, 2014 Apr. PMID 24606217, Free PMC Article
    2. Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. Meng Q, et al. J Biol Chem, 2006 Dec 1. PMID 16982625
    3. TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. Korrodi-Gregório L, et al. Biol Open, 2013 May 15. PMID 23789093, Free PMC Article
    4. Identification of the human testis protein phosphatase 1 interactome. Fardilha M, et al. Biochem Pharmacol, 2011 Nov 15. PMID 21382349
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 40 novel TCTEX1D4 interactors in human spermatozoa have been identified.
      Title: TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein light chain Tctex-type 4
    Names
    Tctex1 domain containing 4
    Tctex2 beta
    novel Tctex-1 family domain-containing protein
    protein N22.1
    tctex-2-beta
    tctex1 domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013632.4 → NP_001013654.1  dynein light chain Tctex-type 4

      See identical proteins and their annotated locations for NP_001013654.1

      Status: VALIDATED

      Source sequence(s)
      AL592166, BC092499, DQ132441
      Consensus CDS
      CCDS30699.1
      UniProtKB/Swiss-Prot
      Q5JR98
      Conserved Domains (1) summary
      cl41776
      Location:108 → 221
      DLC-like_SF; dynein light chain (DLC)-like domain superfamily

    2. NM_001377534.1 → NP_001364463.1  dynein light chain Tctex-type 4

      Status: VALIDATED

      Source sequence(s)
      AL592166
      Consensus CDS
      CCDS30699.1
      UniProtKB/Swiss-Prot
      Q5JR98
      Related
      ENSP00000341803.2, ENST00000339355.3
      Conserved Domains (1) summary
      cl41776
      Location:108 → 221
      DLC-like_SF; dynein light chain (DLC)-like domain superfamily

    3. NM_001377535.1 → NP_001364464.1  dynein light chain Tctex-type 4

      Status: VALIDATED

      Source sequence(s)
      AL592166
      Consensus CDS
      CCDS30699.1
      UniProtKB/Swiss-Prot
      Q5JR98
      Conserved Domains (1) summary
      cl41776
      Location:108 → 221
      DLC-like_SF; dynein light chain (DLC)-like domain superfamily

    4. NM_001377536.1 → NP_001364465.1  dynein light chain Tctex-type 4

      Status: VALIDATED

      Source sequence(s)
      AL592166
      Consensus CDS
      CCDS30699.1
      UniProtKB/Swiss-Prot
      Q5JR98
      Conserved Domains (1) summary
      cl41776
      Location:108 → 221
      DLC-like_SF; dynein light chain (DLC)-like domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      44805893..44807351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419617.1 → XP_047275573.1  dynein light chain Tctex-type 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5JR98

    2. XM_047419619.1 → XP_047275575.1  dynein light chain Tctex-type 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5JR98

    3. XM_047419618.1 → XP_047275574.1  dynein light chain Tctex-type 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5JR98
      Related
      ENSP00000501642.1, ENST00000675259.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      44677047..44678505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336368.1 → XP_054192343.1  dynein light chain Tctex-type 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5JR98

    2. XM_054336369.1 → XP_054192344.1  dynein light chain Tctex-type 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5JR98

    3. XM_054336370.1 → XP_054192345.1  dynein light chain Tctex-type 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5JR98
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JR98.1 GenPept UniProtKB/Swiss-Prot:Q5JR98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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