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    TP53I13 tumor protein p53 inducible protein 13 [ Homo sapiens (human) ]

    Gene ID: 90313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TP53I13provided by HGNC
    Official Full Name
    tumor protein p53 inducible protein 13provided by HGNC
    Primary source
    HGNC:HGNC:25102
    See related
    Ensembl:ENSG00000167543 AllianceGenome:HGNC:25102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSCP1
    Summary
    Involved in several processes, including negative regulation of cell cycle; response to UV; and response to xenobiotic stimulus. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 17.1), spleen (RPKM 12.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TP53I13 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (29566300..29582340)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (30510000..30525212)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27895294..27900175)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TAO kinase 1 Neighboring gene RNA, U6 small nuclear 1034, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11978 Neighboring gene MPRA-validated peak2781 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27853602-27854102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27854103-27854603 Neighboring gene uncharacterized LOC124904148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27896259-27896759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8376 Neighboring gene abhydrolase domain containing 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27911138-27911952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27911953-27912765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27914948-27915847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27916747-27917646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11982 Neighboring gene GIT ArfGAP 1 Neighboring gene ankyrin repeat domain 13B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27940429-27941292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27942158-27943021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8384 Neighboring gene Sharpr-MPRA regulatory region 12866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8385 Neighboring gene coronin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. Hata T, et al. Int J Oncol, 2004 Mar. PMID 14767535
    2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743
    3. A dual-activity topoisomerase complex regulates mRNA translation and turnover. Su S, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35748872, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to UV IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor protein p53-inducible protein 13
    Names
    damage-stimulated cytoplasmic protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346077.1 → NP_001333006.1  tumor protein p53-inducible protein 13 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AC104564

    2. NM_001346078.1 → NP_001333007.1  tumor protein p53-inducible protein 13 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AC104564

    3. NM_001346079.2 → NP_001333008.1  tumor protein p53-inducible protein 13 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC104564

    4. NM_001346081.2 → NP_001333010.1  tumor protein p53-inducible protein 13 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (d).
      Source sequence(s)
      AC104564

    5. NM_001346082.1 → NP_001333011.1  tumor protein p53-inducible protein 13 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has an alternate 5' end, lacks an alternate exon, and uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (d).
      Source sequence(s)
      AC104564

    6. NM_138349.4 → NP_612358.3  tumor protein p53-inducible protein 13 isoform a precursor

      See identical proteins and their annotated locations for NP_612358.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL551604, BC001593
      Consensus CDS
      CCDS42289.1
      UniProtKB/Swiss-Prot
      Q7L5U3, Q8NBR0
      Related
      ENSP00000301057.7, ENST00000301057.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      29566300..29582340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437003.1 → XP_047292959.1  tumor protein p53-inducible protein 13 isoform X2

    2. XM_047437000.1 → XP_047292956.1  tumor protein p53-inducible protein 13 isoform X2

    3. XM_047437001.1 → XP_047292957.1  tumor protein p53-inducible protein 13 isoform X2

    4. XM_047437002.1 → XP_047292958.1  tumor protein p53-inducible protein 13 isoform X2

    5. XM_047437005.1 → XP_047292961.1  tumor protein p53-inducible protein 13 isoform X2

    6. XM_047437004.1 → XP_047292960.1  tumor protein p53-inducible protein 13 isoform X2

    7. XM_047436999.1 → XP_047292955.1  tumor protein p53-inducible protein 13 isoform X1

    8. XM_047437006.1 → XP_047292962.1  tumor protein p53-inducible protein 13 isoform X3

    9. XM_047437007.1 → XP_047292963.1  tumor protein p53-inducible protein 13 isoform X4

    10. XM_047437008.1 → XP_047292964.1  tumor protein p53-inducible protein 13 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      30510000..30525212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317688.1 → XP_054173663.1  tumor protein p53-inducible protein 13 isoform X2

    2. XM_054317689.1 → XP_054173664.1  tumor protein p53-inducible protein 13 isoform X2

    3. XM_054317690.1 → XP_054173665.1  tumor protein p53-inducible protein 13 isoform X2

    4. XM_054317692.1 → XP_054173667.1  tumor protein p53-inducible protein 13 isoform X2

    5. XM_054317687.1 → XP_054173662.1  tumor protein p53-inducible protein 13 isoform X2

    6. XM_054317691.1 → XP_054173666.1  tumor protein p53-inducible protein 13 isoform X2

    7. XM_054317686.1 → XP_054173661.1  tumor protein p53-inducible protein 13 isoform X1

    8. XM_054317693.1 → XP_054173668.1  tumor protein p53-inducible protein 13 isoform X3

    9. XM_054317694.1 → XP_054173669.1  tumor protein p53-inducible protein 13 isoform X4

    10. XM_054317695.1 → XP_054173670.1  tumor protein p53-inducible protein 13 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NBR0.1 GenPept UniProtKB/Swiss-Prot:Q8NBR0

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