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    DNAJC5G DnaJ heat shock protein family (Hsp40) member C5 gamma [ Homo sapiens (human) ]

    Gene ID: 285126, updated on 27-Nov-2024

    Summary

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    Official Symbol
    DNAJC5Gprovided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C5 gammaprovided by HGNC
    Primary source
    HGNC:HGNC:24844
    See related
    Ensembl:ENSG00000163793 MIM:613946; AllianceGenome:HGNC:24844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSP-gamma
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 12.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See DNAJC5G in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27275433..27281499)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27306154..27323119)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27498301..27504367)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11291 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27454350-27455549 Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27465505-27466704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27472326-27473120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27473121-27473914 Neighboring gene solute carrier family 30 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11296 Neighboring gene tripartite motif containing 54 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:27524348-27524553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27543343-27543946 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15498 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27545801-27546773 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Piette BL, et al. Mol Cell, 2021 Jun 17. PMID 33957083
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40417

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 5G
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
    cysteine string protein-gamma
    gamma-CSP
    gamma-cysteine string protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303127.2 → NP_001290056.1  dnaJ homolog subfamily C member 5G isoform 1

      See identical proteins and their annotated locations for NP_001290056.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC013413, AK097736, BC035194
      Consensus CDS
      CCDS1744.1
      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Related
      ENSP00000384305.1, ENST00000402462.5
      Conserved Domains (2) summary
      COG0484
      Location:13 → 98
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 95
      DnaJ; DnaJ domain

    2. NM_001303128.2 → NP_001290057.1  dnaJ homolog subfamily C member 5G isoform 2

      See identical proteins and their annotated locations for NP_001290057.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC013413, AK097736, AK302239, BC035194
      Consensus CDS
      CCDS77397.1
      UniProtKB/Swiss-Prot
      Q8N7S2
      Related
      ENSP00000385533.1, ENST00000406962.1
      Conserved Domains (1) summary
      cl02542
      Location:17 → 41
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    3. NM_173650.3 → NP_775921.1  dnaJ homolog subfamily C member 5G isoform 1

      See identical proteins and their annotated locations for NP_775921.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC013413, AF368277, AI183575, AK097736, BC035194
      Consensus CDS
      CCDS1744.1
      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Related
      ENSP00000296097.3, ENST00000296097.8
      Conserved Domains (2) summary
      COG0484
      Location:13 → 98
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 95
      DnaJ; DnaJ domain

    RNA

    1. NR_130126.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC013413, AK097736, BC035194, DB454465

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27275433..27281499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003872.3 → XP_016859361.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Conserved Domains (2) summary
      COG0484
      Location:13 → 98
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 95
      DnaJ; DnaJ domain

    2. XM_017003873.3 → XP_016859362.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Conserved Domains (2) summary
      COG0484
      Location:13 → 98
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 95
      DnaJ; DnaJ domain

    3. XM_006711995.4 → XP_006712058.1  dnaJ homolog subfamily C member 5G isoform X1

      See identical proteins and their annotated locations for XP_006712058.1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Conserved Domains (2) summary
      COG0484
      Location:13 → 98
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 95
      DnaJ; DnaJ domain

    4. XM_017003874.3 → XP_016859363.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8
      UniProtKB/TrEMBL
      B5MCA9
      Related
      ENSP00000385829.1, ENST00000404433.5
      Conserved Domains (2) summary
      COG0484
      Location:13 → 98
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:17 → 95
      DnaJ; DnaJ domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27306154..27323119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341502.1 → XP_054197477.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8

    2. XM_054341505.1 → XP_054197480.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8

    3. XM_054341506.1 → XP_054197481.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8

    4. XM_054341504.1 → XP_054197479.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8

    5. XM_054341503.1 → XP_054197478.1  dnaJ homolog subfamily C member 5G isoform X1

      UniProtKB/Swiss-Prot
      B4DY29, Q53SY5, Q8IYQ4, Q8N7S2, Q96RJ8

    6. XM_054341507.1 → XP_054197482.1  dnaJ homolog subfamily C member 5G isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N7S2.1 GenPept UniProtKB/Swiss-Prot:Q8N7S2

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