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    FNDC1 fibronectin type III domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 84624, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FNDC1provided by HGNC
    Official Full Name
    fibronectin type III domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:21184
    See related
    Ensembl:ENSG00000164694 MIM:609991; AllianceGenome:HGNC:21184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGS8; FNDC2; MEL4B3; bA243O10.1; dJ322A24.1
    Summary
    Predicted to act upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Predicted to be located in cell-cell junction; mitochondrial membrane; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in gall bladder (RPKM 10.5), thyroid (RPKM 9.5) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FNDC1 in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (159169400..159272108)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (160415015..160517654)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159590432..159693140)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TAGAP antisense RNA 1 Neighboring gene MPRA-validated peak6279 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25382 Neighboring gene MPRA-validated peak6280 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:159461684-159462883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25383 Neighboring gene uncharacterized LOC112267968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25384 Neighboring gene T cell activation RhoGTPase activating protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25385 Neighboring gene uncharacterized LOC124901449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25386 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159538123-159538330 Neighboring gene VISTA enhancer hs2576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:159591287-159591786 Neighboring gene Sharpr-MPRA regulatory region 9512 Neighboring gene FNDC1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159659176-159659360 Neighboring gene FNDC1 intronic transcript 1 Neighboring gene MPRA-validated peak6281 silencer Neighboring gene uncharacterized LOC105378084 Neighboring gene long intergenic non-protein coding RNA 2529

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [FNDC1 is highly expressed in lung adenocarcinoma and closely related with poor prognosis]. Hong H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Aug 20. PMID 36073217, Free PMC Article
    2. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Seki T, et al. Arthritis Rheum, 1998 Aug. PMID 9704633
    3. Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates. Gao M, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657397, Free PMC Article
    4. Overexpression of FNDC1 Relates to Poor Prognosis and Its Knockdown Impairs Cell Invasion and Migration in Gastric Cancer. Liu YP, et al. Technol Cancer Res Treat, 2019 Jan 1. PMID 31530096, Free PMC Article
    5. The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway. Yunwen C, et al. Mol Med Rep, 2021 Jun. PMID 33899120, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of miR-143-3p/FNDC1 axis on the progression of non-small cell lung cancer.
      Title: The role of miR-143-3p/FNDC1 axis on the progression of non-small cell lung cancer.
    2. [FNDC1 is highly expressed in lung adenocarcinoma and closely related with poor prognosis].
      Title: [FNDC1 is highly expressed in lung adenocarcinoma and closely related with poor prognosis].
    3. Up-regulated FNDC1 accelerates stemness and chemoradiation resistance in colorectal cancer cells.
      Title: Up-regulated FNDC1 accelerates stemness and chemoradiation resistance in colorectal cancer cells.
    4. The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway.
      Title: The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway.
    5. The findings elaborated the biological role of fibronectin type III domain containing 1 in gastric cancer and potential mechanism of action, possibly providing a new insight for future clinical diagnosis or even molecular therapy
      Title: Overexpression of FNDC1 Relates to Poor Prognosis and Its Knockdown Impairs Cell Invasion and Migration in Gastric Cancer.
    6. activator of G-protein signaling 8 regulated the trafficking of VEGFR-3 to the plasma membrane
      Title: VEGFR-3 signaling is regulated by a G-protein activator, activator of G-protein signaling 8, in lymphatic endothelial cells.
    7. these studies have revealed a novel microRNA-1207-3p/FNDC1/FN1/AR regulatory pathway in prostate cancer.
      Title: miR-1207-3p regulates the androgen receptor in prostate cancer via FNDC1/fibronectin.
    8. Knockdown of AGS8 inhibited vascular endothelial growth factor (VEGF)-induced tube formation, as well as VEGF-stimulated cell growth and migration.
      Title: Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. mechanical stretching of FN-III1 may induce fibrillogenesis through a partially unfolded intermediate
      Title: Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1866

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III domain-containing protein 1
    Names
    activation-associated cDNA protein
    expressed in synovial lining protein
    fibronectin type III domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032532.3 → NP_115921.2  fibronectin type III domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_115921.2

      Status: VALIDATED

      Source sequence(s)
      AL356417, AL590551, DQ009660
      Consensus CDS
      CCDS47512.1
      UniProtKB/Swiss-Prot
      A6H8X2, B7ZBR4, B7ZBR5, B9EK49, Q4ZHG4, Q5JPI0, Q5VU31, Q5VU32, Q5VXX4, Q70CQ6, Q96JG1
      UniProtKB/TrEMBL
      J3KNQ2
      Related
      ENSP00000297267.9, ENST00000297267.14
      Conserved Domains (2) summary
      smart00060
      Location:40 → 120
      FN3; Fibronectin type 3 domain
      cd00063
      Location:1658 → 1749
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      159169400..159272108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536190.3 → XP_011534492.1  fibronectin type III domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      J3KNQ2
      Conserved Domains (2) summary
      smart00060
      Location:40 → 120
      FN3; Fibronectin type 3 domain
      cd00063
      Location:1635 → 1726
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_011536191.3 → XP_011534493.1  fibronectin type III domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      J3KNQ2
      Conserved Domains (2) summary
      smart00060
      Location:41 → 124
      FN3; Fibronectin type 3 domain
      cd00063
      Location:1541 → 1632
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      160415015..160517654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356563.1 → XP_054212538.1  fibronectin type III domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      J3KNQ2

    2. XM_054356564.1 → XP_054212539.1  fibronectin type III domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      J3KNQ2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4ZHG4.4 GenPept UniProtKB/Swiss-Prot:Q4ZHG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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