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    Tbcb tubulin folding cofactor B [ Mus musculus (house mouse) ]

    Gene ID: 66411, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tbcbprovided by MGI
    Official Full Name
    tubulin folding cofactor Bprovided by MGI
    Primary source
    MGI:MGI:1913661
    See related
    Ensembl:ENSMUSG00000006095 AllianceGenome:MGI:1913661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CG22; CKAPI; Ckap1; 2410007D12Rik
    Summary
    Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be located in cytosol. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human TBCB (tubulin folding cofactor B). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 59.9), CNS E14 (RPKM 49.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbcb in Genome Data Viewer
    Location:
    7 B1; 7 17.33 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29923554..29931622, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30224129..30232197, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4914 Neighboring gene predicted gene, 53356 Neighboring gene STARR-seq mESC enhancer starr_18511 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene STARR-positive B cell enhancer ABC_E6531 Neighboring gene STARR-positive B cell enhancer ABC_E6532 Neighboring gene calpain, small subunit 1 Neighboring gene STARR-seq mESC enhancer starr_18512 Neighboring gene STARR-positive B cell enhancer ABC_E4915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31016881-31016990 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide I Neighboring gene ovo like zinc finger 3 Neighboring gene WD repeat domain 62 Neighboring gene ribosomal protein S12, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tubulin cofactor B plays a role in the neuronal growth cone. Lopez-Fanarraga M, et al. J Neurochem, 2007 Mar. PMID 17217416
    2. Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. Kortazar D, et al. Exp Cell Res, 2007 Feb 1. PMID 17184771
    3. Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued). Kuh GF, et al. Cell Tissue Res, 2012 Oct. PMID 22777741
    4. Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice. Ganay T, et al. Mol Neurodegener, 2011 Apr 12. PMID 21486449, Free PMC Article
    5. Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy. Wen HL, et al. Hum Mol Genet, 2010 May 1. PMID 20176735

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tubulin complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin-folding cofactor B
    Names
    cytoskeleton-associated protein 1
    cytoskeleton-associated protein CKAPI
    tubulin-specific chaperone B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360648.1 → NP_001347577.1  tubulin-folding cofactor B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC149067
      Conserved Domains (2) summary
      pfam01302
      Location:110 → 178
      CAP_GLY; CAP-Gly domain
      cl00155
      Location:1 → 41
      UBQ; Ubiquitin-like proteins

    2. NM_001360649.1 → NP_001347578.1  tubulin-folding cofactor B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA718358, AC149067
      Conserved Domains (1) summary
      cd01789
      Location:10 → 92
      Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B

    3. NM_025548.4 → NP_079824.2  tubulin-folding cofactor B isoform 1

      See identical proteins and their annotated locations for NP_079824.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC149067
      Consensus CDS
      CCDS21083.1
      UniProtKB/Swiss-Prot
      Q9CWR6, Q9D1E6, Q9DCZ6
      Related
      ENSMUSP00000006254.6, ENSMUST00000006254.6
      Conserved Domains (2) summary
      cd01789
      Location:10 → 92
      Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B
      pfam01302
      Location:162 → 229
      CAP_GLY; CAP-Gly domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29923554..29931622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1E6.2 GenPept UniProtKB/Swiss-Prot:Q9D1E6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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