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    NREP neuronal regeneration related protein [ Homo sapiens (human) ]

    Gene ID: 9315, updated on 9-Dec-2024

    Summary

    Official Symbol
    NREPprovided by HGNC
    Official Full Name
    neuronal regeneration related proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16834
    See related
    Ensembl:ENSG00000134986 MIM:607332; AllianceGenome:HGNC:16834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P311; PTZ17; SEZ17; D4S114; C5orf13; PRO1873
    Summary
    Predicted to be involved in axon regeneration; regulation of neuron differentiation; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 38.4), placenta (RPKM 35.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NREP in Genome Data Viewer
    Location:
    5q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (111728802..111976932, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (112239135..112487266, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (111064499..111312629, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene STARD4 antisense RNA 1 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:111092091-111092648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16235 Neighboring gene RN7SK pseudogene 57 Neighboring gene uncharacterized LOC105379122 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 14 Neighboring gene NREP antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111326855-111327356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111327357-111327856 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:111333199-111334398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22904 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:111496090-111497289 Neighboring gene EPB41L4A antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:111501161-111501838 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:111501839-111502516 Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC124901044 Neighboring gene small nucleolar RNA, H/ACA box 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of neuronal regeneration related protein homolog (rat, NREP; P311; C5orf13) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuronal regeneration-related protein
    Names
    neuronal protein 3.1
    neuronal regeneration related protein homolog
    protein p311

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142474.2NP_001135946.1  neuronal regeneration-related protein isoform b

      See identical proteins and their annotated locations for NP_001135946.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes alternate exons in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform b, which is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC022108, AC025182, DA027062, DA694580
      Conserved Domains (1) summary
      pfam11092
      Location:37102
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    2. NM_001142475.2NP_001135947.1  neuronal regeneration-related protein isoform c

      See identical proteins and their annotated locations for NP_001135947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes alternate exons in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform c, which is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC022108, AC025182, DC365764
      Consensus CDS
      CCDS47255.1
      UniProtKB/Swiss-Prot
      Q16612
      Related
      ENSP00000378996.3, ENST00000395634.7
      Conserved Domains (1) summary
      pfam11092
      Location:47112
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    3. NM_001142476.1NP_001135948.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA490948, DA526263
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000392559.2, ENST00000455559.6
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    4. NM_001142477.1NP_001135949.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA939543
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000427476.1, ENST00000513100.5
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    5. NM_001142478.2NP_001135950.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, AC114297, AL547663, BC011050
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000368993.3, ENST00000379671.7
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    6. NM_001142479.1NP_001135951.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA520221, DA704824
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000399766.2, ENST00000419114.6
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    7. NM_001142480.1NP_001135952.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA704824, DA744980
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    8. NM_001142481.1NP_001135953.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA752769
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000422630.1, ENST00000509427.5
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    9. NM_001142482.1NP_001135954.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA683910
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000402965.2, ENST00000446294.6
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    10. NM_001142483.1NP_001135955.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA078027, DA534424
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000408839.2, ENST00000447165.6
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)
    11. NM_004772.4NP_004763.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_004763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (a). Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      BC072443, CN415439
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000257435.7, ENST00000257435.12
      Conserved Domains (1) summary
      pfam11092
      Location:368
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      111728802..111976932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      112239135..112487266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353798.1XP_054209773.1  neuronal regeneration-related protein isoform X1