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    ANP32B acidic nuclear phosphoprotein 32 family member B [ Homo sapiens (human) ]

    Gene ID: 10541, updated on 27-Nov-2024

    Summary

    Official Symbol
    ANP32Bprovided by HGNC
    Official Full Name
    acidic nuclear phosphoprotein 32 family member Bprovided by HGNC
    Primary source
    HGNC:HGNC:16677
    See related
    Ensembl:ENSG00000136938 MIM:619823; AllianceGenome:HGNC:16677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APRIL; SSP29; PHAPI2
    Summary
    Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 88.8), lymph node (RPKM 73.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ANP32B in Genome Data Viewer
    Location:
    9q22.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (97983341..98015943)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (110155281..110187884)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100745623..100778225)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase O Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28679 Neighboring gene hemogen Neighboring gene Sharpr-MPRA regulatory region 4249 Neighboring gene CRISPRi-validated cis-regulatory element chr9.1594 Neighboring gene uncharacterized LOC124902226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100745493-100746375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20110 Neighboring gene uncharacterized LOC124902225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28681 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:100797789-100798988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28684 Neighboring gene RNA, U6 small nuclear 918, pseudogene Neighboring gene uncharacterized LOC124902227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28686 Neighboring gene tripartite motif containing 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev The interaction of Rev with ANP32B is decreased by the presence of RRE PubMed
    rev HIV-1 Rev interacting protein, acidic (leucine-rich) nuclear phosphoprotein 32 family, member B (ANP32B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in inner ear development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    colocalizes_with nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    acidic leucine-rich nuclear phosphoprotein 32 family member B
    Names
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
    acidic protein rich in leucines
    putative HLA-DR-associated protein I-2
    silver-stainable protein SSP29

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006401.3NP_006392.1  acidic leucine-rich nuclear phosphoprotein 32 family member B

      See identical proteins and their annotated locations for NP_006392.1

      Status: VALIDATED

      Source sequence(s)
      AW296974, BC019658, BP395780
      Consensus CDS
      CCDS6732.1
      UniProtKB/Swiss-Prot
      B2R9C7, O00655, P78458, P78459, Q92688
      Related
      ENSP00000345848.4, ENST00000339399.5
      Conserved Domains (2) summary
      sd00035
      Location:90113
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam14580
      Location:71146
      LRR_9; Leucine-rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      97983341..98015943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      110155281..110187884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)