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    OR1L8 olfactory receptor family 1 subfamily L member 8 [ Homo sapiens (human) ]

    Gene ID: 138881, updated on 27-Nov-2024

    Summary

    Official Symbol
    OR1L8provided by HGNC
    Official Full Name
    olfactory receptor family 1 subfamily L member 8provided by HGNC
    Primary source
    HGNC:HGNC:15110
    See related
    Ensembl:ENSG00000171496 AllianceGenome:HGNC:15110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR9-24
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See OR1L8 in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122546271..122583384, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (134764443..134780693, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125329396..125345663, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily J member 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:125299684-125300883 Neighboring gene olfactory receptor family 1 subfamily J member 4 Neighboring gene olfactory receptor family 1 subfamily N member 1 Neighboring gene olfactory receptor family 1 subfamily N member 2 Neighboring gene uncharacterized LOC124902265 Neighboring gene olfactory receptor family 1 subfamily H member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily Q member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 1L8
    Names
    olfactory receptor OR9-24

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004454.2NP_001004454.1  olfactory receptor 1L8

      See identical proteins and their annotated locations for NP_001004454.1

      Status: VALIDATED

      Source sequence(s)
      AL162254, AL359636
      Consensus CDS
      CCDS35124.1
      UniProtKB/Swiss-Prot
      A3KFM3, B9EIR6, Q6IF15, Q8NGR8, Q96R79
      UniProtKB/TrEMBL
      A0A126GVC5
      Related
      ENSP00000493411.1, ENST00000641027.1
      Conserved Domains (2) summary
      pfam00001
      Location:42290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:32308
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      122546271..122583384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014285.2XP_016869774.1  olfactory receptor 1L8 isoform X1

      UniProtKB/Swiss-Prot
      A3KFM3, B9EIR6, Q6IF15, Q8NGR8, Q96R79
      UniProtKB/TrEMBL
      A0A126GVC5
      Conserved Domains (2) summary
      pfam00001
      Location:42290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:32308
      7tm_4; Olfactory receptor
    2. XM_017014286.2XP_016869775.1  olfactory receptor 1L8 isoform X1

      UniProtKB/Swiss-Prot
      A3KFM3, B9EIR6, Q6IF15, Q8NGR8, Q96R79
      UniProtKB/TrEMBL
      A0A126GVC5
      Conserved Domains (2) summary
      pfam00001
      Location:42290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:32308
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      134764443..134780693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)