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    XKRY XK related, Y-linked (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 9082, updated on 10-Dec-2024

    Summary

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    Official Symbol
    XKRYprovided by HGNC
    Official Full Name
    XK related, Y-linked (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:18571
    See related
    Ensembl:ENSG00000290724 MIM:400015; AllianceGenome:HGNC:18571
    Gene type
    pseudo
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XKRY1
    Summary
    This probable pseudogene is located in the nonrecombining portion of the Y chromosome, and is expressed specifically in testis. It is similar to the XK (X-linked Kell blood group precursor) gene, which encodes a putative membrane transport protein. This gene is present as two identical copies within a palindromic region; this record represents the more centromeric copy. [provided by RefSeq, Nov 2020]
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    Genomic context

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    See XKRY in Genome Data Viewer
    Location:
    Yq11.222
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (17768980..17770560, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (18675537..18677117, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (19880860..19882440, complement)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene PTPN13 like Y-linked pseudogene 1 Neighboring gene actin gamma 1 pseudogene 2 Neighboring gene USP9Y pseudogene 23 Neighboring gene RNA, U1 small nuclear 128, pseudogene Neighboring gene USP9Y pseudogene 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kell and Kx, two disulfide-linked proteins of the human erythrocyte membrane are phosphorylated in vivo. Carbonnet F, et al. Biochem Biophys Res Commun, 1998 Jun 29. PMID 9647734
    2. Y Chromosome Infertility. Adam MP, et al. , 1993. PMID 20301513
    3. Functional coherence of the human Y chromosome. Lahn BT, et al. Science, 1997 Oct 24. PMID 9381176
    4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Skaletsky H, et al. Nature, 2003 Jun 19. PMID 12815422
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Spermatogenic failure, Y-linked, 2
    MedGen: C1839071 OMIM: 415000 GeneReviews: Y Chromosome Infertility
    		Compare labs

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • X Kell blood group precursor-related, Y-linked
    • X-linked Kx blood group related, Y-linked
    • XK related, Y-linked
    • XK, Kell blood group complex subunit-related, Y-linked
    • testis-specific XK-related protein on Y
    • testis-specific XK-related protein, Y-linked 2

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in single fertilization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_171026.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007742
      Related
      ENST00000624960.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      17768980..17770560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      18675537..18677117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_032917.1: Suppressed sequence

      Description
      NG_032917.1: This RefSeq was removed because the gene type has changed from protein-coding to transcribed pseudogene. The protein-coding reference transcript on this RefSeqGene has been replaced by a non-coding transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14609.1 GenPept UniProtKB/Swiss-Prot:O14609

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials