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    OLIG3 oligodendrocyte transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 167826, updated on 9-Dec-2024

    Summary

    Official Symbol
    OLIG3provided by HGNC
    Official Full Name
    oligodendrocyte transcription factor 3provided by HGNC
    Primary source
    HGNC:HGNC:18003
    See related
    Ensembl:ENSG00000177468 MIM:609323; AllianceGenome:HGNC:18003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Bhlhb7; bHLHe20
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See OLIG3 in Genome Data Viewer
    Location:
    6q23.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (137492199..137494394, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (138680645..138682841, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137813336..137815531, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378017 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137636227-137636827 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:137672426-137672621 Neighboring gene FOXA motif-containing MPRA enhancer 183 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90385 Neighboring gene uncharacterized LOC102723633 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137744471-137745316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:137808523-137809198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137814441-137814940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:137816622-137817155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:137817156-137817688 Neighboring gene Sharpr-MPRA regulatory region 8938 Neighboring gene basic transcription factor 3 like 4 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25141 Neighboring gene Sharpr-MPRA regulatory region 13388 Neighboring gene OLIG3-TNFAIP3 interval homotypic cluster of transcription factor binding sites enhancer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17585 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90442 Neighboring gene NANOG hESC enhancer GRCh37_chr6:137974082-137974598 Neighboring gene uncharacterized LOC105378018 Neighboring gene long intergenic non-protein coding RNA 3004

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
    EBI GWAS Catalog
    Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spinal cord motor neuron cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spinal cord motor neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    oligodendrocyte transcription factor 3
    Names
    class B basic helix-loop-helix protein 7
    class E basic helix-loop-helix protein 20
    oligo3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175747.2NP_786923.1  oligodendrocyte transcription factor 3

      See identical proteins and their annotated locations for NP_786923.1

      Status: VALIDATED

      Source sequence(s)
      AK096362
      Consensus CDS
      CCDS5186.1
      UniProtKB/Swiss-Prot
      Q7RTU3, Q8N8Q0
      Related
      ENSP00000356708.2, ENST00000367734.4
      Conserved Domains (1) summary
      pfam00010
      Location:85138
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      137492199..137494394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      138680645..138682841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)